Figures & data
Figure 8 Rectal retention time.
Notes: 5FU microemulsion and TG-5FU-ME with 0.1%Cy7NHS ester were administered into the rectum, 0.5 cm above the anus using a stomach probe needle. (A–C) 5FU microemulsion (2 minutes, 5 minutes, 10 minutes after administration); (D–F) TG-5FU-ME (2 minutes, 1 hour, 5 hours after administration).
Abbreviations: 5FU, 5-fluorouracil; TG-5FU-ME, thermosensitive gel-mediated 5FU water-in-oil microemulsion; Cpx, count per second.
Abbreviations: 5FU, 5-fluorouracil; TG-5FU-ME, thermosensitive gel-mediated 5FU water-in-oil microemulsion; Cpx, count per second.
![Figure 8 Rectal retention time.](/cms/asset/e8a54e25-10ab-49ca-8d83-52147d3e46f6/dddt_a_12183749_f0001_c.jpg)
Figure 10 The morphology of rectal tissues after exposure to 5FU thermosensitive gel and TG-5FU-ME.
Notes: The rat’s rectal tissue was taken 12 hours after TG-5FU-ME (A) and 5FU thermosensitive gel (B) administration (20 mg kg−1 of 5FU) through rectal route. Tissue slides were examined with H&E staining (×200).
Abbreviations: 5FU, 5-fluorouracil; H&E, hematoxylin and eosin; TG-5FU-ME, thermosensitive gel-mediated 5FU water-in-oil microemulsion.
Abbreviations: 5FU, 5-fluorouracil; H&E, hematoxylin and eosin; TG-5FU-ME, thermosensitive gel-mediated 5FU water-in-oil microemulsion.
![Figure 10 The morphology of rectal tissues after exposure to 5FU thermosensitive gel and TG-5FU-ME.](/cms/asset/0555a921-212d-4e73-a6da-0c2b965f0b8d/dddt_a_12183749_f0002_c.jpg)