Figures & data
Table 1 Mathematical Model Fitting Results of LCTG
Table 2 The Comprehensive Scoring Results of Eye Irritation Response
Figure 3 The representative result of Draize test on 7th day (A:the gel group, B:the control group).
![Figure 3 The representative result of Draize test on 7th day (A:the gel group, B:the control group).](/cms/asset/9f282469-e0a4-4b6a-8dac-797c7c132a99/dddt_a_12184111_f0003_c.jpg)
Table 3 The Quantity of Tear Fluid of Groups (Mm, n = 12, ± s)
Figure 7 The quantity of tear fluid of groups (n = 12, ± s). (N: the normal group; (M) the model group; (S) the solution group; (G) the gel group. Compare with (N)***P < 0.001, **P < 0.01; Compare with (M)###P < 0.001; Compare with (S)+++P < 0.001.).
![Figure 7 The quantity of tear fluid of groups (n = 12, X¯ ± s). (N: the normal group; (M) the model group; (S) the solution group; (G) the gel group. Compare with (N)***P < 0.001, **P < 0.01; Compare with (M)###P < 0.001; Compare with (S)+++P < 0.001.).](/cms/asset/929391fe-c71a-4202-9cfe-bad24d1a2844/dddt_a_12184111_f0007_b.jpg)
Table 4 The Consequence Score of Corneal FLS Staining (n = 12, ± s)
Figure 8 The FLS staining condition of groups (N: the normal group; (M) the model group; (S) the solution group; G: the gel group.).
![Figure 8 The FLS staining condition of groups (N: the normal group; (M) the model group; (S) the solution group; G: the gel group.).](/cms/asset/188f4ce8-3402-4865-ac3c-55e2a3ec3a05/dddt_a_12184111_f0008_c.jpg)
Figure 9 The consequence score of corneal FLS staining (n = 12, x ± s). (N:the normal group; (M) the model group; (S) the solution group; (G) the gel group.Compare with (N)***P < 0.001, **P < 0.01; Compare with (M)#P < 0.05).
![Figure 9 The consequence score of corneal FLS staining (n = 12, x ± s). (N:the normal group; (M) the model group; (S) the solution group; (G) the gel group.Compare with (N)***P < 0.001, **P < 0.01; Compare with (M)#P < 0.05).](/cms/asset/e7c232d9-51ff-483a-a603-dba6ecea6cad/dddt_a_12184111_f0009_b.jpg)
Figure 10 The form of lacrimal gland (N:the normal group; (M) the model group; (S) the solution group; (G) the gel group.).
![Figure 10 The form of lacrimal gland (N:the normal group; (M) the model group; (S) the solution group; (G) the gel group.).](/cms/asset/50b12c7e-20d5-4e1f-9f68-dcfc705ff25d/dddt_a_12184111_f0010_c.jpg)
Table 5 Measurement Results of Central Corneal Epithelial Layer Thickness (μm, n = 5, ± s)
Figure 11 The form of cornea (N:the normal group; (M) the model group; (S) the solution group; (G) the gel group. The area marked by yellow line segment represented corneal epithelium layer.
![Figure 11 The form of cornea (N:the normal group; (M) the model group; (S) the solution group; (G) the gel group. The area marked by yellow line segment represented corneal epithelium layer.](/cms/asset/ca1ab785-a6b5-4779-8424-1dd6d41167d5/dddt_a_12184111_f0011_c.jpg)
Figure 12 Measurement results of central corneal epithelial layer thickness (μm, n = 5, x ± s. (N) the normal group; (M) the model group; (S) the solution group; (G) the gel group. Compared with (N)*P < 0.05; Compared with (M) #P < 0.05).
![Figure 12 Measurement results of central corneal epithelial layer thickness (μm, n = 5, x ± s. (N) the normal group; (M) the model group; (S) the solution group; (G) the gel group. Compared with (N)*P < 0.05; Compared with (M) #P < 0.05).](/cms/asset/bee0727e-0473-48b5-848f-6e547ecac627/dddt_a_12184111_f0012_b.jpg)
Table 6 The Apoptosis Rate of Corneal Epithelial Cells (%, n = 3, ± s)
Figure 13 The apoptosis rate of corneal epithelial cells after 3 days of the administrations (N: the normal group; (M) the model group; (S) the solution group; (G) the gel group. The green fluorescence indicated the nucleus of positive apoptotic cells while blue fluorescence represented the nucleus of other cells.).
![Figure 13 The apoptosis rate of corneal epithelial cells after 3 days of the administrations (N: the normal group; (M) the model group; (S) the solution group; (G) the gel group. The green fluorescence indicated the nucleus of positive apoptotic cells while blue fluorescence represented the nucleus of other cells.).](/cms/asset/0806f00c-c82f-4b09-a973-f1a4add4315e/dddt_a_12184111_f0013_c.jpg)
Figure 14 The apoptosis rate of corneal epithelial cells after 7 days of the administrations (N: the normal group; (M) the model group; (S) the solution group; (G) the gel group. The green fluorescence indicated the nucleus of positive apoptotic cells while blue fluorescence represented the nucleus of other cells.).
![Figure 14 The apoptosis rate of corneal epithelial cells after 7 days of the administrations (N: the normal group; (M) the model group; (S) the solution group; (G) the gel group. The green fluorescence indicated the nucleus of positive apoptotic cells while blue fluorescence represented the nucleus of other cells.).](/cms/asset/edb6b7c0-c6a5-4b4d-a320-da3de37e3f65/dddt_a_12184111_f0014_c.jpg)
Figure 15 The apoptosis rate of corneal epithelial cells (n = 3, ± s. (N) the normal group; (M) the model group; (S) the solution group; (G) the gel group. Compared with (N)***P < 0.001, **P < 0.01; Compared with (M)#P < 0.05.).
![Figure 15 The apoptosis rate of corneal epithelial cells (n = 3, X¯ ± s. (N) the normal group; (M) the model group; (S) the solution group; (G) the gel group. Compared with (N)***P < 0.001, **P < 0.01; Compared with (M)#P < 0.05.).](/cms/asset/0235ffee-51bd-47d3-90eb-d650a66d86fd/dddt_a_12184111_f0015_b.jpg)