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Original Research

Design, Synthesis, Characterization and in vivo Antidiabetic Activity Evaluation of Some Chalcone Derivatives

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Pages 3119-3129 | Published online: 17 Jul 2021

Figures & data

Scheme 1 Reagents and conditions: 60% aq. NaOH, Ethanol, RT.

Scheme 1 Reagents and conditions: 60% aq. NaOH, Ethanol, RT.

Table 1 Structures of the Synthesized Chalcone Derivatives (1–5)

Table 2 Effect of Test Compounds in Postprandial Hyperglycemia Post-Glucose Load in Normal Mice

Table 3 Effect of Test Compounds at Two Dose Levels and Each Time Points in Reducing Postprandial Hyperglycemia

Figure 1 (A) Comparative inhibitory effect of the synthesized compounds in postprandial hyperglycemia post-glucose load in normal mice at a dose of 50 mg/kg. (B) Comparative inhibitory effect of the synthesized compounds in postprandial hyperglycemia post-glucose load in normal mice at a dose of 100 mg/kg.

Figure 1 (A) Comparative inhibitory effect of the synthesized compounds in postprandial hyperglycemia post-glucose load in normal mice at a dose of 50 mg/kg. (B) Comparative inhibitory effect of the synthesized compounds in postprandial hyperglycemia post-glucose load in normal mice at a dose of 100 mg/kg.

Table 4 Effect of Synthesized Compounds (Each 100 Mg/Kg) on Fasting Blood Glucose Level of STZ-Induced Diabetic Mice

Table 5 Effect of Synthesized Compounds (Each 100 Mg/Kg) on Body Weight of STZ-Induced Diabetic Mice

Figure 2 Chemical structure of the synthesized compounds (1–5).

Figure 2 Chemical structure of the synthesized compounds (1–5).