Figures & data
Figure 1 Chemical structure of simvastatin.
Table 1 Composition of various formulations of SEDDSs for simvastatin
Table 2 Composition of different formulations of S-SEDDSs for simvastatin
Table 3 Composition of different formulations of simvastatin self-emulsifying tablets
Table 4 Solubility of simvastatin in oils and their combination with Tween 60
Figure 2 (A) FTIR spectra of pure simvastatin, (B) simvastatin solution prepared in a mixture of olive oil and Tween 60, and (C) simvastatin solution prepared in castor oil and Tween 60.
Table 5 Emulsification time and cloud point of self-emulsified formulations
Table 6 Results of precompression evaluation of powder blends for different formulations of SEDDS-based tablets
Table 7 Physical parameters and mechanical strength of SEDDS-based tablets
Figure 3 Disintegration time of different formulations of simvastatin self-emulsified tablets. Disintegration time was determined according to USP for six tablets (n=6), using purified water as media held at 37°±2°C.
Figure 4 Dissolution rate from different formulations of simvastatin self-emulsified tablets.
Figure 5 Comparison of cumulative drug release after 15 (Q15 min) and 30 min (Q30 min).
