Single early instillation of mitomycin C and urinary alkalinization in low-risk non-muscle-invasive bladder cancer: a preliminary study

Figures & data

Table 1 Demographic and clinical characteristics of patients in treatment groups

Variables	Standard n = 11	Optimized n = 15	Control n = 23	P value
Age, years (mean ± SD)	59.3 ± 14.9	63.5 ± 15.0	61.9 ± 10.2	0.716
Gender				0.395
Male, n (%)	9 (81.8)	13 (86.7)	22 (95.7)
Female, n (%)	2 (18.2)	2 (13.3)	1 (4.3)
Tumor size, mm (mean ± SD)	18.3 ± 7.9	19.1 ± 8.4	19.4 ± 7.8	0.858
Duration of follow-up, months, median (range)	51 (12–60)	50 (12–59)	54 (38–60)	0.815
Occupational risk factors				0.264
None, n (%)	9 (81.8)	13 (86.7)	18 (78.2)
Present, n (%)	2 (18.2)	2 (13.3)	5 (21.8)
History of smoking				0.124
None, n (%)	4 (36.4)	4 (26.7)	2 (8.7)
Present, n (%)	7 (63.6)	11 (73.3)	21 (91.3)

Abbreviation: SD, standard deviation.

Table 2 Risk factors that may have impact on recurrence-free survival

Variables	RFSR (%)			Mean time to recurrence (95% CI)	Log-rank	P value
	One-year	Three-year	Five-year
Gender					0.09	0.769
Male (n = 44)	90.9	85.9	85.9	53.0 (47.7–58.2)
Female (n = 5)	100.0	66.7		44.9 (28.6–61.1)
Occupational risk factors					0.77	0.382
None (n = 40)	93.3	85.8	85.8	53.3 (48.3–58.3)
Present (n = 9)	75.0	75.0		40.7 (23.2–58.2)
History of smoking					0.21	0.645
None (n = 10)	100.0	85.7	85.7	54.9 (45.8–64.1)
Present (n = 39)	89.7	84.2	84.2	52.1 (46.3–57.9)

Abbreviations: CI, confidence interval; RFSR, recurrence-free survival rate.

Table 3 Recurrence-free survival rates and median time to recurrence in treatment groups

Groups	RFSR (%)			Mean time to recurrence (95% CI)	Log-rank	P value
	One-year	Three-year	Five-year
Standard (n = 11)	100.0	100.0	100.0	–
Optimized (n = 15)	86.7	79.4	79.4	34.8 (28.5–41.1)
Control (n = 23)	91.3	82.6	82.6	51.8 (44.3–59.2)
General (n = 49)	91.8a,b	84.7a,c	84.7b,c	52.7 (47.7–57.7)	2.43	0.297

Notes:

a Between standard and optimized groups (P = 0.132);

b between standard and control groups (P = 0.173);

c between optimized and control groups (P = 0.645).

Abbreviations: CI, confidence interval; RFSR, recurrence-free survival rate.

Figure 1 Kaplan-Meier curve showing rate of recurrence-free survival in all patients.