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Drug Design, Development and Therapy Volume 17, 2023 - Issue
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ORIGINAL RESEARCH

Efficacy and Safety of Anlotinib in Overall and Disease-Specific Advanced Gynecological Cancer: A Real-World Study

Xinyi Hong1 Department of Obstetrics and Gynecology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, People’s Republic of China
,
Shanhu Qiu2 Department of General Practice, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, People’s Republic of China
,
Xia Wu3 Department of Gynecological Oncology, Tumor Hospital Affiliated to Nantong University, Nantong, Jiangsu, People’s Republic of China
,
Sizhen Chen4 Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing, People’s Republic of China
,
Xiaoxiang Chen5 Department of Gynecological Oncology, Jiangsu Cancer Hospital, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-2400-4749
ORCID Icon,
Bei Zhang6 Department of Obstetrics and Gynecology, Xuzhou Central Hospital, Xuzhou, People’s Republic of China
,
Aiqin He3 Department of Gynecological Oncology, Tumor Hospital Affiliated to Nantong University, Nantong, Jiangsu, People’s Republic of China
,
Yun Xu7 Department of Obstetrics and Gynecology, The First People's Hospital of Changzhou, Changzhou, People’s Republic of China
,
Jianqing Wang8 Department of Obstetrics and Gynecology, The Yancheng Clinical College of Xuzhou Medical University, The First People’s Hospital of Yancheng, Yancheng, People’s Republic of China
,
Yingchun Gao9 Department of Obstetrics and Gynecology, Huai’an First People’s Hospital, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huai’an, People’s Republic of China
,
Xizhong Xu10 Department of Obstetrics and Gynecology, The Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China
,
Li Sun11 Department of Gynecological Oncology, Qingdao Central Hospital, The Second Affiliated Hospital of Medical College of Qingdao University, Qingdao, People’s Republic of China
,
Yang Zhang12 Gynecology Department, The First People's Hospital of Lianyungang, Lianyungang, People’s Republic of China
,
Libing Xiang13 Ovarian Cancer Program, Department of Gynecologic Oncology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China
,
Jundong Zhou14 Radio-oncology Department, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, People’s Republic of China
,
Qun Guan15 Gynecology Department, Jiangsu Province Hospital of Chinese Medicine, Nanjing, People’s Republic of China
,
Yanling Zhu16 Gynecology Department, Xuzhou Cancer Hospital, Xuzhou, People’s Republic of China
,
Haiyan Liu17 Department of Obstetrics and Gynecology, Affiliated Hospital of Yangzhou University, Yangzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0009-0006-3196-5747
ORCID Icon,
Hao Xu18 Gynecology Department, Huangshi Love & Health Hospital Affiliated to Hubei Polytechnic University, Huangshi, People’s Republic of China
,
Ying Zhou19 The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, People’s Republic of China
,
Bingwei Chen4 Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0159-3699
ORCID Icon &
Yang Shen1 Department of Obstetrics and Gynecology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1077-7273
ORCID Icon show all
Pages 2025-2033 | Received 12 Feb 2023, Accepted 03 Jun 2023, Published online: 06 Jul 2023

Figures & data

Figure 1 Study flowchart.

Figure 1 Study flowchart.

Table 1 Baseline Characteristics

Figure 2 Lines of treatment prior to the use of Anlotinib. Distribution of the number of previous treatment lines prior to the use of Anlotinib. (a) in the total study population. (b) in patients with ovarian cancer. (c) in patients with cervical cancer. (d) in patients with endometrial cancer.

Figure 2 Lines of treatment prior to the use of Anlotinib. Distribution of the number of previous treatment lines prior to the use of Anlotinib. (a) in the total study population. (b) in patients with ovarian cancer. (c) in patients with cervical cancer. (d) in patients with endometrial cancer.

Table 2 Analysis of the Efficacy of Anlotinib

Table 3 Treatment-Related Adverse Events of Any Grade and Grade 3/4 AEs in All Patients

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