The Effect of Different Doses of Ciprofol in Patients with Painless Gastrointestinal Endoscopy

Figures & data

Figure 1 Flow diagram of the study.

Table 1 Comparison of General Conditions in Patients Among the Four Groups () (n)

Group	Number	Gender (Male/Female)	Age (Years)	BMI (kg/m^2)	ASA PS (I/II/III)	Surgical Type (Gastroscope/Enteroscopy)	Operative Time (Min)
P	44	18/26	43.55±16.19	22.16±3.06	19/19/6	31/13	15.98±6.63
C2	38	22/16	52.03±13.54	23.41±2.77	12/12/14	20/18	18.21±8.91
C3	36	12/24	45.58±17.04	22.65±3.53	15/10/11	21/15	19.75±10.53
C4	31	11/20	47.45±11.90	22.99±3.01	14/12/5	18/13	19.77±9.28
F/c^2		5.598	2.329	1.192	8.578	5.336	1.628
P		0.133	0.077	0.315	0.199	0.149	0.185

Note: Data are presented as the mean±standard deviation or as numbers with percentages.

Abbreviations: BMI, body mass index; ASA PS, American Society of Anesthesiologists physical status.

Table 2 Comparison of Sedative Effects in Patients Among the Four Groups ()

Group	Number	Time for Disappearance of Eyelash Reflex (s)	Time of Awakening (Min)
P	44	85.45±55.98	1.45±1.25
C2	38	42.63±14.46^a	1.32±1.19
C3	36	43.33±20.00^a	1.08±0.37
C4	31	52.58±18.61^a	1.10±0.40
F		14.702	1.402
P		<0.001	0.245

Notes: Compared to the group P, ^aP < 0.05.

Table 3 SBP, DBP, HR and SPO₂ at Different Time in Patients Among Four Groups ()

Index	Group	Number	Preoperative Basic Data	Intraoperative Data
SBP (mmHg)	P	44	132.02±17.88	98.55±15.78
	C2	38	140.66±18.69	111.95±13.73^a
	C3	36	135.53±20.48	115.47±14.72^a
	C4	31	128.94±18.48	99.35±15.70^b,c
DBP (mmHg)	P	44	74.84±10.44	57.64±10.28
	C2	38	73.92±11.72	62.42±8.07
	C3	36	76.92±11.02	67.42±9.86^a
	C4	31	73.87±10.81	59.68±9.71^c
HR (beats/min)	P	44	75.86±9.81	66.91±6.49
	C2	38	81.05±11.53	74.24±9.57^a
	C3	36	79.89±12.02	72.69±8.75^a
	C4	31	77.84±11.06	68.81±8.28^b
SPO2 (%)	P	44	0.99±0.01	0.98±0.03
	C2	38	0.98±0.01	0.99±0.02
	C3	36	0.98±0.01	0.99±0.01
	C4	31	0.99±0.01	0.98±0.03

Notes: Compared to the group P, ^aP < 0.05; Compared to the group C2, ^bP < 0.05; Compared to the group C3, ^cP < 0.05.

Table 4 Incidence of Adverse Reactions in Patients Among Four Groups (n, %)

Group	Number	Nausea and Vomiting	Respiratory Depression	Injection Pain
P	44	2 (4.5%)	4 (9.1%)	5 (11.4%)
C2	38	0^a	0^a	0^a
C3	36	0^a	0^a	0^a
C4	31	0^a	4 (12.9%)^b,c	0^a

Notes: Compared to the group P, ^aP < 0.05; Compared to the group C2, ^bP < 0.05; Compared to the group C3, ^cP < 0.05.

Figure 2 The MOAA/S scores of propofol group and ciprofol each group at T₁, T₂ and T₃.

Note: Data were expressed as the mean ± standard deviation.

Abbreviation: MOAA/S, Modified Observer’s Assessment of Alertness/Sedation.

Data Sharing Statement

The datasets generated from the current study are available from the corresponding author, Jianfeng Huang, upon reasonable request.