New approaches to the management of schizophrenia: focus on aberrant hippocampal drive of dopamine pathways

Figures & data

Figure 1 PV-positive interneurons primarily synapse on the axon initial segment of pyramidal neurons of the vHipp (inset).

Notes: Individuals with schizophrenia exhibit lower levels of PV expression, which is suggested to lead to deficits in GABAergic signaling and subsequent hyperactivity of the vHipp. This hyperactivity is thought to underlie the dysregulation of dopamine transmission in schizophrenia. Adapted by permission from Macmillan Publishers Ltd: Nat Rev Neurosci, Lewis DA, Hashimoto T, Volk DW. Cortical inhibitory neurons and schizophrenia, 2005;6:312–324, copyright 2005.⁷⁰ Adapted with permission from Grace AA, Floresco SB, Goto Y, Lodge DJ. Regulation of firing of dopaminergic neurons and control of goal-directed behaviors. Trends Neurosci. 2007;30(5):220–227.¹³⁸
Abbreviations: mPFC, medial prefrontal cortex; NAc, nucleus accumbens; PV, parvalbumin; vHipp, ventral hippocampus; Pyr, pyramidal neuron; VTA, ventral tegmental area; GABA, gamma-aminobutyric acid.

Lewis DA Hashimoto T Volk DW Cortical inhibitory neurons and schizophrenia Nat Rev Neurosci 2005 6 312 324 15803162

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Grace AA Floresco SB Goto Y Lodge DJ Regulation of firing of dopaminergic neurons and control of goal-directed behaviors Trends Neurosci 2007 30 5 220 227 17400299

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