Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine

Figures & data

Figure 1 Skin microanatomy.

Note: © 2012 Elsevier Limited. Reproduced with permission from van der Maaden K, Jiskoot W, Bouwstra J. Microneedle technologies for (trans)dermal drug and vaccine delivery. J Control Release. 2012;161(2):645–655.¹⁵

Figure 2 (A–E) Commonly seen dissolving microneedles and the drug-release procedure.

Note: © 2008 Elsevier Limited. Reproduced with permission from Lee JW, Park JH, Prausnitz MR. Dissolving microneedles for transdermal drug delivery. Biomaterials. 2008;29(13):2113–2124.²³

Figure 3 Microneedle separation into the skin was mediated by hydrogel swelling.

Note: © 2012 Elsevier Limited. Reproduced with permission from Kim M, Jung B, Park JH. Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin. Biomaterials. 2012;33(2):668–678.³²

Figure 4 Separable arrowhead microneedles.

Note: © 2011 Elsevier Limited. Reproduced with permission from Chu LY, Prausnitz MR. Separable arrowhead microneedles. J Control Release. 2011;149(3):242–249.³³

Figure 5 Sustained vaccine release from “multilayer tattoo” microneedles.

Note: © 2013 Elsevier Limited. Reproduced with permission from DeMuth PC, Min Y, Huang B, et al. Polymer multilayer tattooing for enhanced DNA vaccination. Nat Mater. 2013;12(4):367–376.³⁷
Abbreviations: uv-PNMP, poly(o-nitrobenzyl-methacrylate-co-methyl-methacrylate-co-poly(ethylene-glycol)-methacrylate) on brief exposure to ultraviolet; PBAE, biodegradable poly(β-amino-ester); PS, protamine-sulphate; pGag, gag polyprotein; poly(I:C), polyriboinosinic polyribocytidylic acid; SPS, poly(4-styrene-sulphonate).

van der Maaden K Jiskoot W Bouwstra J Microneedle technologies for (trans)dermal drug and vaccine delivery J Control Release 2012 161 2 645 655 22342643

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Lee JW Park JH Prausnitz MR Dissolving microneedles for transdermal drug delivery Biomaterials 2008 29 13 2113 2124 18261792

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Kim M Jung B Park JH Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin Biomaterials 2012 33 2 668 678 22000788

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Chu LY Prausnitz MR Separable arrowhead microneedles J Control Release 2011 149 3 242 249 21047538

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DeMuth PC Min Y Huang B Polymer multilayer tattooing for enhanced DNA vaccination Nat Mater 2013 12 4 367 376 23353628

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