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Review

Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine

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Pages 945-952 | Published online: 04 Sep 2013

Figures & data

Figure 1 Skin microanatomy.

Note: © 2012 Elsevier Limited. Reproduced with permission from van der Maaden K, Jiskoot W, Bouwstra J. Microneedle technologies for (trans)dermal drug and vaccine delivery. J Control Release. 2012;161(2):645–655.Citation15
Figure 1 Skin microanatomy.

Figure 2 (A–E) Commonly seen dissolving microneedles and the drug-release procedure.

Note: © 2008 Elsevier Limited. Reproduced with permission from Lee JW, Park JH, Prausnitz MR. Dissolving microneedles for transdermal drug delivery. Biomaterials. 2008;29(13):2113–2124.Citation23
Figure 2 (A–E) Commonly seen dissolving microneedles and the drug-release procedure.

Figure 3 Microneedle separation into the skin was mediated by hydrogel swelling.

Note: © 2012 Elsevier Limited. Reproduced with permission from Kim M, Jung B, Park JH. Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin. Biomaterials. 2012;33(2):668–678.Citation32
Figure 3 Microneedle separation into the skin was mediated by hydrogel swelling.

Figure 4 Separable arrowhead microneedles.

Note: © 2011 Elsevier Limited. Reproduced with permission from Chu LY, Prausnitz MR. Separable arrowhead microneedles. J Control Release. 2011;149(3):242–249.Citation33
Figure 4 Separable arrowhead microneedles.

Figure 5 Sustained vaccine release from “multilayer tattoo” microneedles.

Note: © 2013 Elsevier Limited. Reproduced with permission from DeMuth PC, Min Y, Huang B, et al. Polymer multilayer tattooing for enhanced DNA vaccination. Nat Mater. 2013;12(4):367–376.Citation37
Abbreviations: uv-PNMP, poly(o-nitrobenzyl-methacrylate-co-methyl-methacrylate-co-poly(ethylene-glycol)-methacrylate) on brief exposure to ultraviolet; PBAE, biodegradable poly(β-amino-ester); PS, protamine-sulphate; pGag, gag polyprotein; poly(I:C), polyriboinosinic polyribocytidylic acid; SPS, poly(4-styrene-sulphonate).
Figure 5 Sustained vaccine release from “multilayer tattoo” microneedles.