Clinical Study of Flumazenil Antagonizing Remimazolam on Nausea and Vomiting After Gynecologic Day Surgery

Figures & data

Table 1 General Information of Patients

Index	Group F (n = 71)	Group C (n = 70)	P
Age (years, )	41.14±8.52	42.41±9.17	0.40
Weight [kg, M(Q1~Q3)]	62 (50.6,67)	61.5 (56.75,70)	0.78
BMI [kg/ m^2, M(Q1~Q3)]	23.63 (21.61,25.56)	23.95 (22.67,26.06)	0.17
ASA grade			0.21
I	44 (61.97)	38 (54.29)
II	27 (38.03)	32 (45.71)
Apfel Score			0.48
2	50 (70.42)	53 (75.7)
3	21 (29.58)	17 (24.3)
Operative category			0.29
Hysteroscopy	56 (78.87)	60 (85.71)
Cone cutting	15 (21.13)	10 (14.29)

Abbreviations: BMI, body mass index; ASA, American Society of Anesthesiologists.

Figure 1 Research flow chart A. total of 163 patients were initially included in the study, but the data of 9 patients were missing, and the other 5 patients did not meet the inclusion criteria and were excluded. Of the 149 patients collected, 8 were lost to follow-up, and 141 patients completed the trial.

Table 2 Comparison of Anesthesia Time and Dosage of Medication

Index	Group F (n = 71)	Group C (n = 70)	P
Anesthesia induction time [Second, M(Q1~Q3)]	95 (85,106)	90 (75,110)	0.32
Anesthesia maintenance time [minute, M(Q1~Q3)]	19.7 (15,25)	18.5 (15,26.25)	0.93
Total dose of remimazolam [mg, M(Q1~Q3)]	31 (26,38)	30.1 (25.8,36.83)	0.58
Total dose of alfentanil [mg, M(Q1~Q3)]	1.79 (1.58,2.1)	1.81 (1.64,2.17)	1.00
Total dose of mivacurium chloride [mg, M(Q1~Q3)]	13 (11,13)	13 (11.75,15)	0.31

Table 3 Primary and Secondary Observational Indicators

Index	Group F (n = 71)	Group C (n = 70)	P
PACU in PONV [example (%)]	4 (5.6)	6 (8.6)	0.5
The incidence of PONV at 24 hours after operation [example (%)]	36 (50.70)	25 (32.86)	0.03
Mean arterial pressure before medication (mmHg, )	78±11.75	81.63±12.22	0.18
Mean arterial pressure after (mmHg, )	90.07±12.14	89.29±10.48	0.69
Pre-dose heart rate (Times/minute, )	62.39±9.38	65.34±9.53	0.66
Post-medication heart rate (Times/minute, )	71.03±11.6	70.82±11.99	0.92

Figure 2 Comparison of MAP at different time points between the two groups of patients P=0.123>0.05.