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ORIGINAL RESEARCH

Clinical Efficacy of Taxol Plus Platinum (TP) Chemotherapy Combined with Delayed Administration of PD-1 Inhibitors in Patients with Locally Advanced, Recurrent or Metastatic Esophageal Squamous Cell Carcinoma: A Retrospective Study

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Pages 2761-2773 | Received 03 Feb 2024, Accepted 19 Jun 2024, Published online: 03 Jul 2024

Figures & data

Table 1 Patient Characteristics of the 34 ESCC Patients

Figure 1 Flow chart of patient’s selection.

Figure 1 Flow chart of patient’s selection.

Figure 2 Percentage change of tumor size after the treatment. Each bar represents one patient with the best response in the dimension of target lesions.

Figure 2 Percentage change of tumor size after the treatment. Each bar represents one patient with the best response in the dimension of target lesions.

Figure 3 Kaplan–Meier curves of PFS and OS. PFS (A) and OS (B) for all patients (n=34). PFS (C) and OS (D) for patients who did not receive radical surgery treatment (n=27). PFS, progression-free survival; OS, overall survival.

Figure 3 Kaplan–Meier curves of PFS and OS. PFS (A) and OS (B) for all patients (n=34). PFS (C) and OS (D) for patients who did not receive radical surgery treatment (n=27). PFS, progression-free survival; OS, overall survival.

Figure 4 Kaplan–Meier curves of PFS and OS between different groups of NLR at different cycle of treatment. Kaplan–Meier curves of PFS at baseline (A), at second (B), third (C) and fourth (D) cycle of treatment. Kaplan–Meier curves of OS at baseline (E), at second (F), third (G) and fourth (H) cycle of treatment. PFS, progression-free survival; OS, overall survival; NLR, neutrophil-to-lymphocyte ratio.

Figure 4 Kaplan–Meier curves of PFS and OS between different groups of NLR at different cycle of treatment. Kaplan–Meier curves of PFS at baseline (A), at second (B), third (C) and fourth (D) cycle of treatment. Kaplan–Meier curves of OS at baseline (E), at second (F), third (G) and fourth (H) cycle of treatment. PFS, progression-free survival; OS, overall survival; NLR, neutrophil-to-lymphocyte ratio.

Figure 5 Kaplan–Meier curves of PFS and OS between different groups of PLR at different cycle of treatment. Kaplan–Meier curves of PFS at baseline (A), at second (B), third (C) and fourth (D) cycle of treatment. Kaplan–Meier curves of OS at baseline (E), at second (F), third (G) and fourth (H) cycle of treatment. PFS, progression-free survival; OS, overall survival; PLR, platelet-to-lymphocyte ratio.

Figure 5 Kaplan–Meier curves of PFS and OS between different groups of PLR at different cycle of treatment. Kaplan–Meier curves of PFS at baseline (A), at second (B), third (C) and fourth (D) cycle of treatment. Kaplan–Meier curves of OS at baseline (E), at second (F), third (G) and fourth (H) cycle of treatment. PFS, progression-free survival; OS, overall survival; PLR, platelet-to-lymphocyte ratio.

Figure 6 Kaplan–Meier curves of PFS and OS between different groups of MLR at different cycle of treatment. Kaplan–Meier curves of PFS at baseline (A), at second (B), third (C) and fourth (D) cycle of treatment. Kaplan–Meier curves of OS at baseline (E), at second (F), third (G) and fourth (H) cycle of treatment. PFS, progression-free survival; OS, overall survival; MLR, monocyte-to-lymphocyte ratio.

Figure 6 Kaplan–Meier curves of PFS and OS between different groups of MLR at different cycle of treatment. Kaplan–Meier curves of PFS at baseline (A), at second (B), third (C) and fourth (D) cycle of treatment. Kaplan–Meier curves of OS at baseline (E), at second (F), third (G) and fourth (H) cycle of treatment. PFS, progression-free survival; OS, overall survival; MLR, monocyte-to-lymphocyte ratio.

Figure 7 Kaplan–Meier curves of PFS and OS between different groups of PIV at different cycle of treatment. Kaplan–Meier curves of PFS at baseline (A), at second (B), third (C) and fourth (D) cycle of treatment. Kaplan–Meier curves of OS at baseline (E), at second (F), third (G) and fourth (H) cycle of treatment. PFS, progression-free survival; OS, overall survival; PIV, pan-immune-inflammation value.

Figure 7 Kaplan–Meier curves of PFS and OS between different groups of PIV at different cycle of treatment. Kaplan–Meier curves of PFS at baseline (A), at second (B), third (C) and fourth (D) cycle of treatment. Kaplan–Meier curves of OS at baseline (E), at second (F), third (G) and fourth (H) cycle of treatment. PFS, progression-free survival; OS, overall survival; PIV, pan-immune-inflammation value.

Table 2 Incidence of Adverse Events in 34 ESCC Patients Receiving Immunochemotherapy