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Drug Design, Development and Therapy Volume 7, 2013 - Issue
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Original Research

Intratumoral chemotherapy for lung cancer: re-challenge current targeted therapies

Wolfgang Hohenforst-Schmidt1 II Medical Clinic, Coburg Hospital, University of Wuerzburg, Coburg, Germany
,
Paul Zarogoulidis2 Pulmonary Department-Oncology Unit, G Papanikolaou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece;3 Department of Interventional Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital, University Duisburg-Essen, Essen, GermanyCorrespondence[email protected]
,
Kaid Darwiche3 Department of Interventional Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany
,
Thomas Vogl4 Department of Diagnostic and Interventional Radiology, Goethe University of Frankfurt, Frankfurt, Germany
,
Eugene P Goldberg5 Biomaterials Science and Engineering, Department of Materials Science and Engineering, University of Florida, FL, USA
,
Haidong Huang6 Department of Respiratory Diseases, Changhai Hospital/First Affiliated Hospital of the Second Military Medical University, Shanghai, People’s Republic of China
,
Michael Simoff7 Bronchoscopy and Interventional Pulmonology, Pulmonary and Critical Care Medicine, Henry Ford Hospital, Wayne State University, School of Medicine, MI, USA
,
Qiang Li6 Department of Respiratory Diseases, Changhai Hospital/First Affiliated Hospital of the Second Military Medical University, Shanghai, People’s Republic of China
,
Robert Browning8 Pulmonary and Critical Care Medicine, Interventional Pulmonology, National Naval Medical Center, Walter Reed Army Medical Center, Bethesda, MD, USA
,
Francis J Turner9 Pulmonary Medicine, University of Nevada School of Medicine, National Supercomputing Center for Energy and the Environment University of Nevada, Las Vegas, NV, USA
,
Patrick Le Pivert10 Interventional Drug Delivery Systems and Strategies (ID2S2), Medical Cryogenics, Jupiter, FL, USA
,
Dionysios Spyratos2 Pulmonary Department-Oncology Unit, G Papanikolaou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
,
Konstantinos Zarogoulidis2 Pulmonary Department-Oncology Unit, G Papanikolaou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
,
Seyhan I Celikoglu11 Pulmonary Department, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
,
Firuz Celikoglu11 Pulmonary Department, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
&
Johannes Brachmann1 II Medical Clinic, Coburg Hospital, University of Wuerzburg, Coburg, Germany
 show all
Pages 571-583 | Published online: 18 Jul 2013

Figures & data

Table 1 Patient characteristics

Table 2 Intratumoral therapy experience

Figure 1 X-ray from patient 1.

Notes: (A) X-ray upon diagnosis. (B) after one session (1 month). (C) and after two sessions (6 weeks after diagnosis).
Figure 1 X-ray from patient 1.

Figure 2 Patient 2 upon diagnosis.

Notes: (A) Vertical computed tomography image upon diagnosis with ans without contrast. (B) X-ray upon diagnosis. (C) bronchoscopy image upon diagnosis.
Figure 2 Patient 2 upon diagnosis.

Figure 3 CT images from patient 2.

Notes: (A and C) CT upon diagnosis. (B and D) CT after 10 weeks.
Abbreviation: CT, computed tomography.
Figure 3 CT images from patient 2.

Figure 4 Patient 2 bronchoscopy findings upon diagnosis and after 10 weeks of therapy including four ITC-sessions and three reduced systemic carboplatin doublet applications.

Notes: (A) Bronchoscopy image upon diagnosis. (B) Bronchoscopy image after local intratumoral treatment.
Abbreviation: ITC, intratumoral chemotherapy.
Figure 4 Patient 2 bronchoscopy findings upon diagnosis and after 10 weeks of therapy including four ITC-sessions and three reduced systemic carboplatin doublet applications.

Figure 5 Intratumoral chemotherapy model.

Notes: After the local administration, tumor necrosis is observed and micrometastasis occurs through the local abnormal vascular architecture and diffusion through the interstitial fluid.
Abbreviation: IF, interstitial fluid.
Figure 5 Intratumoral chemotherapy model.

Figure 6 Scheme of proposed intratumoral protocol. Timing of intravenous 4-week-cycle with weekly intratumoral chemotherapy.

Abbreviations: d, day; ITC, intratumoral; iv, intravenous.
Figure 6 Scheme of proposed intratumoral protocol. Timing of intravenous 4-week-cycle with weekly intratumoral chemotherapy.

Table 3 Effects and safety features

Table 4 Intratumoral studies using different approaches

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