Effect of ranibizumab on serous and vascular pigment epithelial detachments associated with exudative age-related macular degeneration

Figures & data

Table 1 Patient demographics and baseline characteristics

Characteristic	Group A (vascular PED)	Group B (serous PED)
Sex	17♂, 15♀	17♂, 12♀
Eye affected	12 OD, 20 OS	12 OD, 17 OS
Mean age ± SD (years)	69 ± 8	71 ± 8
Mean baseline BCVA ± SD (logMAR)	0.57 ± 0.28	0.60 ± 0.30
Mean baseline PED height ± SD (μm)	420 ± 110	524 ± 127
Mean average injections ± SD	6.1 ± 1.8	7.1 ± 2.2

Abbreviations: BCVA, best-corrected visual acuity; logMAR, logarithm of the minimum angle of resolution; OD, right eye; OS, left eye; PED, pigment epithelial detachment; SD, standard deviation.

Table 2 Mean BCVA (logMAR)

Group	Baseline Mean ± SD	3 months Mean ± SD	6 months Mean ± SD	12 months Mean ± SD
Group A	0.57 ± 0.28	0.51 ± 0.30	0.51 ± 0.31	0.48 ± 0.32
Group B	0.60 ± 0.30	0.52 ± 0.28	0.50 ± 0.28	0.47 ± 0.28

Abbreviations: BCVA, best-corrected visual acuity; logMAR, logarithm of the minimum angle of resolution; SD, standard deviation.

Table 3 PED height (μm)

Group	Baseline Mean ± SD	3 months Mean ± SD	6 months Mean ± SD	12 months Mean ± SD
Group A	420 ± 110	340 ± 91	317 ± 97	285 ± 114
Group B	524 ± 127	417 ± 113	377 ± 111	344 ± 117

Abbreviations: PED, pigment epithelial detachment; SD, standard deviation.

Figure 1 Selected case: A 76-year-old man was referred for decreased visual acuity in the left eye. Baseline examination, including (A) fundoscopy, (B) fluorescein angiography, (C) ICG angiography, and (D) macular OCT revealed a vascular PED associated with exudative AMD. The baseline BCVA and PED height were 20/80 and 380 μm, respectively. The same eye (E) at 3 months (BCVA: 20/70; PED height: 236 μm), (F) at 6 months (BCVA: 20/70; PED height: 176 μm), and (G) at 12 months (BCVA: 20/60; PED height: 166 μm), after the first ranibizumab injection.

Abbreviations: AMD, age-related macular degeneration; BCVA, best-corrected visual acuity; ICG, indocyanine green; OCT, optical coherence tomography; PED, pigment epithelial detachment.

Figure 2 Selected case: A 72-year-old man was referred for decreased visual acuity in the left eye. Baseline examination, including (A) fundoscopy, (B) fluorescein angiography, (C) ICG angiography, and (D) macular OCT revealed a serous PED associated with exudative AMD. The baseline BCVA and PED height were 20/100 and 385 μm respectively. The same eye (E) at 3 months (BCVA: 20/80; PED height: 358 μm), (F) at 6 months (BCVA: 20/70; PED height: 297 μm), and (G) at 12 months (BCVA: 20/60; PED height: 251 μm) after the first ranibizumab injection.

Abbreviations: AMD, age-related macular degeneration; BCVA, best-corrected visual acuity; ICG, indocyanine green; OCT, optical coherence tomography; PED, pigment epithelial detachment.