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Original Research

Nanoparticle formulation by Büchi B-90 Nano Spray Dryer for oral mucoadhesion

, , , , , , , & show all
Pages 273-282 | Published online: 23 Jan 2015

Figures & data

Figure 1 Dried particles adhere to the drying chamber.

Figure 1 Dried particles adhere to the drying chamber.

Figure 2 Narrow distribution of particle size for the gelatin vildagliptin nanoparticles formulation prepared by the spray-drying technique.

Figure 2 Narrow distribution of particle size for the gelatin vildagliptin nanoparticles formulation prepared by the spray-drying technique.

Figure 3 Surface morphology of the gelatin vildagliptin nanoparticles preparation showing a smooth surface and surface-folding shape.

Abbreviation: KFU, King Faisal University.
Figure 3 Surface morphology of the gelatin vildagliptin nanoparticles preparation showing a smooth surface and surface-folding shape.

Figure 4 Percentage swelling profile.

Abbreviation: GVN, gelatin vildagliptin nanoparticles.
Figure 4 Percentage swelling profile.

Figure 5 In vitro release testing of vildagliptin and the gelatin vildagliptin nanoparticles (GVN) preparation – Peppas model.

Figure 5 In vitro release testing of vildagliptin and the gelatin vildagliptin nanoparticles (GVN) preparation – Peppas model.

Figure 6 Fourier-transform infrared spectra of vildagliptin, aminated gelatin, and nanoparticle formulation.

Figure 6 Fourier-transform infrared spectra of vildagliptin, aminated gelatin, and nanoparticle formulation.

Figure 7 The percentage of gelatin vildagliptin nanoparticles (GVN) retained in the gastrointestinal tract for longer periods of time compared to active pharmaceutical ingredients.

Notes: Representative experiment, n=3. Data presented as means ± standard deviation.
Figure 7 The percentage of gelatin vildagliptin nanoparticles (GVN) retained in the gastrointestinal tract for longer periods of time compared to active pharmaceutical ingredients.

Figure 8 Vildagliptin-content plot for the gelatin vildagliptin nanoparticles (GVN) formulation (real-time storage conditions).

Note: Percentage of label claim refers to drug content.
Figure 8 Vildagliptin-content plot for the gelatin vildagliptin nanoparticles (GVN) formulation (real-time storage conditions).