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Original Research

Design of a gelatin microparticle-containing self-microemulsifying formulation for enhanced oral bioavailability of dutasteride

, , , &
Pages 3231-3238 | Published online: 23 Jun 2015

Figures & data

Table 1 Compositions of gelatin microparticle-containing self-microemulsifying formulations of dutasteride

Table 2 Drug content, particle size, droplet size, and dissolution efficiency of the gelatin microparticle-containing self-microemulsifying formulations of dutasteride

Figure 1 Scanning electron micrographs of gelatin microparticle-containing self-microemulsifying formulations of dutasteride. (A) G3 particles and (B) G13 particles.

Figure 1 Scanning electron micrographs of gelatin microparticle-containing self-microemulsifying formulations of dutasteride. (A) G3 particles and (B) G13 particles.

Figure 2 Effect of gelatin on dissolution profiles of gelatin microparticle-containing self-microemulsifying formulations of dutasteride.

Note: Data are expressed as the mean ± standard deviation (n=4).
Figure 2 Effect of gelatin on dissolution profiles of gelatin microparticle-containing self-microemulsifying formulations of dutasteride.

Figure 3 Effect of gelatin on dissolution profiles of gelatin microparticle-containing self-microemulsifying formulations of dutasteride.

Note: Data are expressed as the mean ± standard deviation (n=4).
Figure 3 Effect of gelatin on dissolution profiles of gelatin microparticle-containing self-microemulsifying formulations of dutasteride.

Figure 4 Effect of surfactant on dissolution profiles of gelatin microparticle-containing self-microemulsifying formulations of dutasteride.

Note: Data are expressed as the mean ± standard deviation (n=4).
Figure 4 Effect of surfactant on dissolution profiles of gelatin microparticle-containing self-microemulsifying formulations of dutasteride.

Figure 5 Effect of Soluplus® on dissolution profiles of gelatin microparticle-containing self-microemulsifying formulations of dutasteride.

Note: Data are expressed as the mean ± standard deviation (n=4).
Figure 5 Effect of Soluplus® on dissolution profiles of gelatin microparticle-containing self-microemulsifying formulations of dutasteride.

Figure 6 Effect of type of dissolution medium on dissolution profiles of gelatin microparticle-containing self-microemulsifying formulation of dutasteride (G13).

Note: Data are expressed as the mean ± standard deviation (n=4).
Figure 6 Effect of type of dissolution medium on dissolution profiles of gelatin microparticle-containing self-microemulsifying formulation of dutasteride (G13).

Table 3 Pharmacokinetic parameters of gelatin microparticle-containing self-microemulsifying formulations of dutasteride in rats

Figure 7 Plasma concentration–time profiles of dutasteride in rats after oral administration of gelatin microparticle-containing self-microemulsifying formulations.

Note: Data are expressed as the mean ± standard deviation (n=5).
Figure 7 Plasma concentration–time profiles of dutasteride in rats after oral administration of gelatin microparticle-containing self-microemulsifying formulations.