Clinical utility, safety, and tolerability of ezogabine (retigabine) in the treatment of epilepsy

Figures & data

Figure 1 Chemical structure of ezogabine.

Table 1 Adverse effects of ezogabine reported in at least 5% of patients with intractable partial seizures in placebo-controlled add-on clinical trials

	Placebo, n = 427 (%)	Ezogabine 600 mg/d, n = 281 (%)	Ezogabine 900 mg/d, n = 273 (%)	Ezogabine 1200 mg/d, n = 259 (%)
Dizziness	38 (8.9)	41 (14.6)	64 (23.4)	84 (32.4)
Somnolence	51 (11.9)	43 (15.3)	67 (24.5)	69 (26.6)
Confusion	11 (2.6)	12 (4.3)	21 (7.7)	42 (16.2)
Headache	68 (15.9)	34 (12.1)	47 (17.2)	39 (15.1)
Fatigue	25 (5.9)	45 (16)	40 (14.7)	34 (13.1)
Coordination disturbance	12 (2.8)	14 (5)	14 (5.1)	30 (11.6)
Blurred vision	9 (2.1)	5 (1.8)	12 (4.4)	27 (10.4)
Memory impairment	11 (2.6)	7 (2.5)	15 (5.5)	24 (9.3)
Vertigo	9 (2.1)	22 (7.8)	21 (7.7)	24 (9.3)
Nausea	22 (5.2)	18 (6.4)	17 (6.2)	22 (8.5)
Attention disturbance	4 (<1)	17 (6)	15 (5.5)	17 (6.6)
Urinary/renal	55 (12.9)	38 (13.5)	35 (12.8)	65 (25.1)
Discontinued due to adverse events	39 (9.1)	41 (14.6)	65 (23.8)	73 (28.2)
Death	3	1	0	1

Adapted from Epilepsy Res. Porter et al; Retigabine as adjunctive therapy in adults with partial-onset seizures: integrated analysis of three pivotal controlled trials. © 2012, with permission from Elsevier.³⁶

PorterRJBurdetteDEGil-NagelARetigabine as adjunctive therapy in adults with partial-onset seizures: integrated analysis of three pivotal controlled trialsEpilepsy Res Epub April 16, 2012

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