Teneligliptin real-world efficacy assessment of type 2 diabetes mellitus patients in India (TREAT-INDIA study)

Figures & data

Table 1 Baseline demographic and clinical characteristics of all patients

Patients characteristics	Number of patients, n (%)
Total number of patients	4305 (100)
Age (years); mean (SD) – 52.96 (9.9)
<60	3160 (73.40)
≥60	1145 (26.60)
Gender
Male	2636 (61.23)
Female	1669 (38.77)
Baseline HbA1c (%); mean (SD) – 8.54 (1.11)
<7.5	564 (13.10)
≥7.5–≤9	2826 (65.64)
>9	915 (21.25)
Baseline FPG (mg/dL); mean (SD) – 172.20 (41.67)
≤126	365 (8.48)
>126	3940 (91.52)
Baseline PPG (mg/dL); mean (SD) – 247.68 (61.50)
≤200	1112 (25.83)
>200	3193 (74.17)
Presence of comorbidities
Hypertension	2182 (50.69)
Dyslipidemia	1763 (40.95)
CV events	53 (1.23)
Active hepatic disease	54 (1.25)
Active renal disease	62 (1.44)
Antidiabetic medications
Teneligliptin monotherapy	186 (4.32)
Teneligliptin + metformin	1208 (28.06)
Teneligliptin + SU	239 (5.55)
Teneligliptin + metformin + SU	1707 (39.65)
Teneligliptin + metformin + AGI	160 (3.71)
Teneligliptin + metformin + SU + AGI	205 (4.76)
Teneligliptin + insulin with or without other antidiabetic drugs	339 (7.87)
Others	261 (6.06)
Other medications
Antihypertensive	1946 (45.20)
Statin	1886 (43.81)
Antiplatelet	254 (5.90)
Antihypertensive + statin + antiplatelet	168 (3.90)

Abbreviations: AGI, alpha glucosidase inhibitor; CV, cardiovascular; FPG, fasting plasma glucose; PPG, postprandial plasma glucose; SD, standard deviation; SU, sulfonylureas; HbA1c, glycosylated hemoglobin.

Figure 1 Use of teneligliptin.

Abbreviations: Met, metformin; SU, sulfonylureas; Teneli, teneligliptin.

Table 2 Mean reduction in glycemic parameters compared to baseline

Category	FPG (mg/dL)	PPG (mg/dL)	HbA1c (%)	% of patients achieved, HbA1c <7%
Overall (n=4305)	51.29±35.41	80.89±54.27	1.37±1.15	37.75
Teneli + Met + AGI (n=160)	58.47±37.23	98.41±40.26	1.43±0.80	51.25
Teneli + Met + SU + AGI (n=205)	67.88±51.32	106.45±73.58	1.81±1.91	42.45
Teneli + Met + SU + Pio (n=119)	58.21±33.83	100.79±56.37	1.24±1.87	19.33
Teneli + insulin with or without other OADs (n=339)	53.73±37.07	101.03±71.48	1.55±1.05	30.08

Note: Values are presented as mean ± standard deviation otherwise mentioned.

Abbreviations: AGI, alpha glucosidase inhibitor; FPG, fasting plasma glucose; HbA1c, hemoglobin A1c; Met, metformin; OADs, oral antidiabetic drugs; Pio, pioglitazone; PPG, postprandial plasma glucose; SU, sulfonylureas; Teneli, teneligliptin.

Figure 2 Mean reduction in glycemic parameters at the end of 3 months.

Notes:P-value <0.0001 for all glycemic parameters in all subgroups.
Abbreviations: FPG, fasting plasma glucose; PPG, postprandial plasma glucose; SU, sulfonylureas.