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Diabetes, Metabolic Syndrome and Obesity Volume 12, 2019 - Issue
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Review

Leptin resistance: underlying mechanisms and diagnosis

Olga Gruzdeva1 Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation, [email protected];2 Federal State Budget Educational Institution of Higher Education, Kemerovo State Medical University of the Ministry of Healthcare of the Russian Federation, Kemerovo, Russian Federation
,
Daria Borodkina3 Autonomous Public Healthcare Institution of the Kemrovo Region, Kemerovo Regional Clinical Hospital Named After S.V. Beliyaev, Regional Center for Diabetes, Kemerovo, Russian Federation
,
Evgenya Uchasova1 Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation, [email protected]Correspondence[email protected]
,
Yulia Dyleva1 Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation, [email protected]
&
Olga Barbarash1 Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation, [email protected];2 Federal State Budget Educational Institution of Higher Education, Kemerovo State Medical University of the Ministry of Healthcare of the Russian Federation, Kemerovo, Russian Federation
Pages 191-198 | Published online: 25 Jan 2019

Figures & data

Figure 1 Mechanisms of leptin resistance.

Note: Several mechanisms have been identified as potentially underlying leptin resistance, including a gene mutation resulting in structural changes in the leptin molecule, leptin transport across the BBB, and deterioration of leptin-receptor function accompanied by hypothalamic inflammation and endoplasmic reticulum stress.
Abbreviation: BBB, blood–brain barrier.
Figure 1 Mechanisms of leptin resistance.

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