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Diabetes, Metabolic Syndrome and Obesity Volume 13, 2020 - Issue
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Original Research

Comparative Effects of Curcumin versus Nano-Curcumin on Insulin Resistance, Serum Levels of Apelin and Lipid Profile in Type 2 Diabetic Rats

Ali Shamsi-Goushki1 Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IranORCID Iconhttps://orcid.org/0000-0001-8838-6339View further author information
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Zinat Mortazavi2 Health Promotion Research Center, Zahedan University of Medical Science, Zahedan, IranCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2563-5259View further author information
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Mohammad Ali Mirshekar3 Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, IranORCID Iconhttps://orcid.org/0000-0002-0449-6440View further author information
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Mahdi Mohammadi2 Health Promotion Research Center, Zahedan University of Medical Science, Zahedan, IranView further author information
,
Nasroallah Moradi-Kor4 Research Centre of Physiology, Semnan University of Medical Sciences, Semnan, IranORCID Iconhttps://orcid.org/0000-0001-9905-6845View further author information
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Saber Jafari-Maskouni1 Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IranORCID Iconhttps://orcid.org/0000-0001-9150-851XView further author information
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Mansour Shahraki5 Department of Nutrition, Zahedan University of Medical Sciences, Zahedan, IranView further author information
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Pages 2337-2346 | Published online: 03 Jul 2020

Figures & data

Figure 1 Effects of curcumin and nano-curcumin on insulin resistance in studied rats. $$$P <0.001 and $P <0.05 in comparision with control group. ###P <0.001 in comparision with STZ group. Data are expressed as Mean ± SD (n = 8), and analyzed by the One-way ANOVA and Tukey’s post hoc tests.

Abbreviations: Ctrl, control group; STZ, diabetic control group; CUR, curcumin; nCUR, nano-curcumin; HOMA-IR, homeostatic model assessment for insulin resistance.

Figure 1 Effects of curcumin and nano-curcumin on insulin resistance in studied rats. $$$P <0.001 and $P <0.05 in comparision with control group. ###P <0.001 in comparision with STZ group. Data are expressed as Mean ± SD (n = 8), and analyzed by the One-way ANOVA and Tukey’s post hoc tests.Abbreviations: Ctrl, control group; STZ, diabetic control group; CUR, curcumin; nCUR, nano-curcumin; HOMA-IR, homeostatic model assessment for insulin resistance.

Figure 2 Effects of curcumin and nano-curcumin on FBS in studied rats. $$$P <0.001 and $$P <0.01 in comparision with control group. ###P <0.001 in comparision with STZ group. Data are expressed as Mean ± SD (n = 8), and analyzed by the One-way ANOVA and Tukey’s post hoc tests.

Abbreviations: Ctrl, control group; STZ, diabetic control group; CUR, curcumin; nCUR, nano-curcumin; FBS, fasting blood sugar.

Figure 2 Effects of curcumin and nano-curcumin on FBS in studied rats. $$$P <0.001 and $$P <0.01 in comparision with control group. ###P <0.001 in comparision with STZ group. Data are expressed as Mean ± SD (n = 8), and analyzed by the One-way ANOVA and Tukey’s post hoc tests.Abbreviations: Ctrl, control group; STZ, diabetic control group; CUR, curcumin; nCUR, nano-curcumin; FBS, fasting blood sugar.

Figure 3 Effects of curcumin and nano-curcumin on serum levels of apelin in studied rats. $$$P <0.001 and $$P <0.01 in comparision with control group. ###P <0.001 and ##P <0.01 in comparision with STZ group. Data are expressed as Mean ± SD (n = 8), and analyzed by the One-way ANOVA and Tukey’s post hoc tests.

Abbreviations: Ctrl, control group; STZ, diabetic control group; CUR, curcumin; nCUR, nano-curcumin.

Figure 3 Effects of curcumin and nano-curcumin on serum levels of apelin in studied rats. $$$P <0.001 and $$P <0.01 in comparision with control group. ###P <0.001 and ##P <0.01 in comparision with STZ group. Data are expressed as Mean ± SD (n = 8), and analyzed by the One-way ANOVA and Tukey’s post hoc tests.Abbreviations: Ctrl, control group; STZ, diabetic control group; CUR, curcumin; nCUR, nano-curcumin.

Figure 4 (A–E) Effects of curcumin and nano-curcumin on serum lipid profile levels in studied rats. Panel A, B, C, D and E show the average of serum levels of cholesterol, triglyceride, LDL, VLDL and HDL, respectively. $$$P <0.001 and $$P <0.01 in comparision with control group. ###P <0.00 in comparision with STZ group. ***P <0.001and *P <0.05 Nano-curcumin in comparision with curcumin group. Data are expressed as Mean ± SD (n = 8), and analyzed by the One-way ANOVA and Tukey’s post hoc tests.

Abbreviations: Ctrl, control group; STZ, diabetic control group; CUR, curcumin; nCUR, nano-curcumin; LDL, low-density lipoprotein; VLDL, very low-density lipoprotein; HDL, high-density lipoprotein.

Figure 4 (A–E) Effects of curcumin and nano-curcumin on serum lipid profile levels in studied rats. Panel A, B, C, D and E show the average of serum levels of cholesterol, triglyceride, LDL, VLDL and HDL, respectively. $$$P <0.001 and $$P <0.01 in comparision with control group. ###P <0.00 in comparision with STZ group. ***P <0.001and *P <0.05 Nano-curcumin in comparision with curcumin group. Data are expressed as Mean ± SD (n = 8), and analyzed by the One-way ANOVA and Tukey’s post hoc tests.Abbreviations: Ctrl, control group; STZ, diabetic control group; CUR, curcumin; nCUR, nano-curcumin; LDL, low-density lipoprotein; VLDL, very low-density lipoprotein; HDL, high-density lipoprotein.

Figure 5 Correlation between insulin resistance and serum level of apelin in studied rats. The results were analyzed by Pearson correlation coefficient. N = 48.

Abbreviation: HOMA-IR, homeostatic model assessment for insulin resistance.

Figure 5 Correlation between insulin resistance and serum level of apelin in studied rats. The results were analyzed by Pearson correlation coefficient. N = 48.Abbreviation: HOMA-IR, homeostatic model assessment for insulin resistance.

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