Serum Heparanase: A New Clinical Biomarker Involved in Senile Metabolic Inflammatory Syndrome

Figures & data

Table 1 Clinical Characteristics of the MIS and the Control Group

	MIS(%)	Control (%)	P value
N	105	52
Sex
Male (%)	95(90.48)	48(92.31)	0.705
Female (%)	10(9.52)	4(7.69)
Age (years)	74.36±6.18	73.71±6.80	0.587
BMI (kg/m^2)	25.65±2.76	23.68±2.85	0.000
SBP (mmHg)	145.61±17.36	137.19±17.23	0.003
DBP (mmHg)	77.66±10.80	75.92±8.67	0.315
Serum creatinine (μmol/L)	76.19±16.72	79.02±15.58	0.309
Albuminuria (%)	16 (15.24)	3 (5.77)	0.146
Concomitant disease
Essential hypertension (%)	84(80.00)	18(34.62)	0.000
Coronary heart disease (%)	29(27.62)	NA
Cerebral infarction (%)	9(8.57)	NA
Benign prostatic hyperplasia (%)	68(64.76)	37(71.15)	0.423
Hyperuricemia (%)	30(28.57)	9(17.31)	0.124
Atrial fibrillation(%)	9(8.57)	1(1.92)	0.208

Notes: data are expressed as mean (±SD) and absolute number (percentage); P<0.05 is considered statistically significant.

Abbreviations: BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; NA, not applicable.

Figure 1 Comparison of the general biochemical characteristics of the MIS group and the control group: (A) FBG, (B) HbA_1C, (C) CHOL, (D) TG, (E) HDL-C and (F) LDL-C in MIS group and the control group; data are expressed as mean (±SD); P<0.05 is considered statistically significant; *, ** and *** indicate P-value less than 0.05, 0.01 and 0.001, respectively.

Abbreviations: FBG, fasting blood glucose; HbA_1C, glycosylated hemoglobin; CHOL, cholesterol; TG, triglyceride; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol.

Figure 2 Comparison of the specific biochemical characteristics of the MIS group and the control group: (A) HPA, (B) CRP and (C) IL-6 in MIS group and the control group; data are expressed as mean (±SD); HPA, heparanase; CRP, C-reactive protein; IL-6, Interleukin-6; P<0.05 is considered statistically significant; * indicate P-value less than 0.05.

Figure 3 Correlations between serum HPA and CRP, IL-6 and clinical indicators in all subjects: Relationships between serum HPA and (A) CRP, (B) IL-6, (C) age, (D) BMI, (E) FBG, (F) HbA1C, (G) CHOL, (H) TG, (I) HDL-C, (J) LDL-C. P<0.05 is considered statistically significant.

Abbreviations: BMI, body mass index; FBG, fasting blood glucose; HbA_1C, glycosylated hemoglobin; CHOL, cholesterol; TG, triglyceride; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; HPA, heparanase; CRP, C-reactive protein; IL-6, interleukin-6.