Relationship Between Serum Amyloid A1 (SAA1) Gene Polymorphisms Studies with Obesity in the Saudi Population

Figures & data

Table 1 Clinical Characteristics Between Obesity Cases and Healthy Controls

S. No.	Baseline Characteristics	Obesity Cases (n=83)	Controls (n=57)	P-value
1	Age (Years)	30.4±6.4	24.4±4.6	0.001
2	Gender (Male: Female)	47 (56.6%): 36 (43.4%)	32 (56.1%): 25 (43.9%)	0.91
3	Weight (kgs)	80.4±18.1	55.07±7.28	<0.001
4	Height (cms)	160.7±8.51	162.1±7.1	0.30
5	BMI (kg/m^2)	30.9±5.61	20.89±1.86	<0.001
6	Family History of Metabolic diseases	0(0%)	0(0%)	1.0
7	Family History of Cardiac diseases	0(0%)	0(0%)	1.0

Table 2 Hardy Weinberg Equilibrium Analysis

S.No	Gene	rs Number	χ ^2	P-value	HWE Criteria
1	SAA1	rs11603089	4.22	0.03	Non-HWE criteria
2	SAA1	rs4638289	3.03	0.08	Non- HWE criteria
3	SAA1	rs7131332	0.35	0.55	HWE criteria

Table 3 Genotype and Allele Frequencies in rs11603089, rs4638289 and rs7131332 Polymorphisms in SAA1 Gene in Obesity Cases and Control Subjects

SNPs	Genotypes/Alleles	Cases (n=83)	Controls (n=57)	Odds Ratio	95% CI	P-value
rs11603089	AA	49 (59.0)	41 (71.9)	Reference	Reference	Reference
	AG	31 (37.3)	12 (21.1)	2.16	0.98–4.73	0.05
	GG	3 (3.6)	4 (7.0)	0.62	0.13–2.96	0.66
	AG+GG vs AA	34 (40.9)	16 (28.1)	1.77	0.86–3.67	0.11
	AG vs AA+GG	31 (37.3)	12 (21.1)	2.23	1.02–4.86	0.04
	GG vs AA+AG	3 (3.6)	4 (7.0)	0.49	0.10–2.31	0.36
	A	129 (77.7)	94 (82.5)	Reference	Reference	Reference
	G	37 (22.3)	20 (17.5)	1.34	0.73–2.47	0.33
rs4638289	AA	25 (30.1)	30 (52.6)	Reference	Reference	Reference
	AT	44 (53.0)	26 (45.6)	2.03	0.98–4.16	0.05
	TT	14 (16.9)	1 (1.8)	16.8	2.06–136.8	0.0009
	AT+TT vs AA	58 (69.9)	27 (47.4)	2.57	1.28–5.19	0.007
	AT vs AA+TT	44 (53.0)	26 (45.6)	1.34	0.68–2.64	0.38
	TT vs AA+AT	14 (16.9)	1 (1.8)	11.36	1.45–89.06	0.004
	A	94 (56.6)	86 (75.4)	Reference	Reference	Reference
	T	72 (43.4)	28 (24.6)	2.35	1.39–3.97	0.001
rs7131332	AA	39 (47.0)	23 (40.4)	Reference	Reference	Reference
	AG	40 (48.2)	28 (49.1)	0.84	0.41–1.70	0.63
	GG	4 (4.8)	6 (10.5)	0.39	0.10–1.54	0.17
	AG+GG vs AA	44 (53.0)	29 (50.9)	1.08	0.55–2.13	0.80
	AG vs AA+GG	40 (48.2)	28 (49.1)	0.96	0.49–1.89	0.91
	GG vs AA+AG	4 (4.8)	6 (10.5)	0.43	0.11–1.60	0.19
	A	118 (71.1)	74 (64.9)	Reference	Reference	Reference
	G	48 (28.9)	40 (35.1)	0.75	0.45–1.25	0.27

Table 4 Linkage Disequilibrium Analysis with SNPs Involved in This Study

	rs11603089	rs4638289	rs7131332
rs11603089	1	0.132	0.16
rs4638289	0.132	1	0.154
rs7131332	0.16	0.154	1

Figure 1 Linkage disequilibrium continuum of the genomic region in chromosome 11 position between 3 SNPs (rs11603089, rs4638289, and rs7131332) in SAA1 gene.