Research Progress on Gestational Diabetes Mellitus and Endothelial Dysfunction Markers

Figures & data

Figure 1 Relationship between influence factors, VECs and IR.

Table 1 Biomarkers and Characteristics of Endothelial Cells

Author and Year	Biomarkers	Synthetic Site	Changes in GDM	Effect	Mechanism of Action in GDM
Malyszko J, 2008^Citation32 Zhang X, 2009^Citation33	vWF	Endothelial cells, megakaryocytes, etc	Rise	Promote platelet adhesion and aggregation and stabilize coagulation function	Increase the degree of IR
Wang F, 2014^Citation28	AT	Liver	Reduce	Maintain the balance of coagulation function	Increase the degree of IR
Di Fulvio P, 2014^Citation34 Winkler G2002^Citation36	TNF-α	Neutrophils, macrophages, etc	Rise	Promote the aggregation and adhesion of inflammatory cells	Increased TNF - α level results in endothelial injury of placenta
Li H, 2012^Citation40	VCAM-1	Endothelial cells	Rise	Mediating adhesion of leukocytes to vascular endothelium	Placental injury caused by elevated VCAM-1 level
Jin ZW, 2018^Citation42 Mittermayer F, 2002^Citation43	ADMA	Widespread	Rise	Inhibition of NOS/no pathway	Induced oxidative stress, leading to low levels of inflammation
Ding GC, 2016^Citation48	VE-cadherin	Endothelial cells	Rise	Maintain the integrity of endothelial cells	Increased incidence of macrosomia
Su N, 2013^Citation50 Chen Y, 2016^Citation51	sICAM-1	Widespread	Rise	Play the role of the body in regulating cell adhesion	Indicate the degree of IR
Salmi AA, 2012^Citation53 Yan YH, 2010^Citation54	PAI-1	Endothelial cells and hepatocytes	Rise	Regulate fibrinolytic activity	Indicate the degree of IR

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