A Comparative Study on Insulin Secretion, Insulin Resistance and Thyroid Function in Patients with Polycystic Ovary Syndrome with and without Hashimoto’s Thyroiditis

Figures & data

Table 1 Comparison of Parameters Between Patients with Polycystic Ovary Syndrome with and without Hashimoto’s Thyroiditis

	Hashimoto’s Thyroiditis (n=52, Mean±SD)	Without Hashimoto’s Thyroiditis (n=112, Mean±SD)	P
Age(years)	26.22±3.93	25.45±5.10	0.297
Height(cm)	158.18±4.95	155.86±22.01	0.464
Weight(kg)	57.05±9.65	61.97±16.23	0.048
BMI(kg/m2)	22.8±3.82	24.62±6.21	0.025
FINS(uIU/mL)	12.47±8.03	10.9±7.18	0.212
30INS(uIU/mL)	101.44±67.78	79.78±44.23	0.044
60INS(uIU/mL)	113.78±82.72	81.62±55.36	0.013
120INS(uIU/mL)	87.06±87.22	70.89±95.64	0.302
180INS(uIU/mL)	42.21±56.99	32.39±28.65	0.253
HOMA-IR	3.01±2.16	2.69±2.21	0.389
FT3(pmol/l)	4.82±0.81	4.94±0.56	0.372
FT4(pmol/l)	16.26±2.44	17.54±2.65	0.004
TSH(mIU/l).	2.82±1.23	2.16±1.15	0.001
FT4/TSH	7.25±4.01	11.05±6.87	<0.001
HDL(mmol/l)	1.28±0.25	1.23±0.27	0.298
TG(mmol/l)	1.31±0.89	1.4±1.01	0.582
TC(mmol/l)	4.69±0.98	4.44±1.05	0.160
LDL(mmol/l)	2.60±0.94	2.54±0.83	0.690

Notes: PCOS with HT compared to PCOS without HT, patients of PCOS with HT Insulin levels at 30 and 60 minutes were significantly higher, FT4 and FT4/TSH ratios were significantly lower and TSH was significantly higher (uncorrected for BMI) (p<0.05).

Table 2 Comparison of Parameters Between Patients with Polycystic Ovary Syndrome with and without Hashimoto’s Thyroiditis (After Correction for Body Mass Index)

	Hashimoto’s Thyroiditis (n=52), Mean(95% CI)	Without Hashimoto’s Thyroiditis (n=112), Mean(95% CI)	P
FINS(uIU/mL)	13.64(11.92, 15.35)	10.59(9.43, 11.76)	0.005
30INS(uIU/mL)	103.45(88.6, 118.3)	78.51(67.85, 89.17)	0.008
60INS(uIU/mL)	120.51(103.05, 137.97)	79.66(67.83, 91.49)	<0.001
120INS(uIU/mL)	92.54(66.24, 118.84)	69.88(52.06, 87.7)	0.163
180INS(uIU/mL)	44.79(33.43, 56.14)	32.38(24.77, 40)	0.076
HOMA-IR	3.33(2.8, 3.85)	2.62(2.26, 2.97)	0.030
FT3 (pmol/l)	4.85(4.67, 5.04)	4.93(4.8, 5.05)	0.506
FT4 (pmol/l)	16.25(15.56, 16.94)	17.37(16.9, 17.84)	0.009
TSH (mIU/l)	2.79(2.46, 3.13)	2.16(1.94, 2.39)	0.002
FT4/TSH	7.3(5.56, 9.04)	11.02(9.84, 12.2)	0.001
HDL(mmol/l)	1.26(1.19, 1.33)	1.23(1.18, 1.28)	0.542
TG(mmol/l)	1.4(1.15, 1.66)	1.37(1.19, 1.55)	0.835
TC(mmol/l)	4.73(4.44, 5.02)	4.37(4.17, 4.58)	0.049
LDL(mmol/l)	2.68(2.44, 2.91)	2.49(2.32, 2.65)	0.191

Notes: Mean adjusted for BMI. PCOS with HT compared to PCOS without HT, patients of PCOS with HT Fasting insulin, 30-minute and 60-minute insulin levels were significantly higher (P<0.05); HOMA-IR levels were significantly higher in PCOS with HT; FT4 and FT4/TSH ratios were significantly lower and TSH was significantly higher; TC was significantly higher (after correction for BMI) (P<0.05).