Investigation of the Reference Interval Values of Fasting Plasma Glucose, Blood Pressure, and Blood Lipids in the Longevity People Aged 90 Years Old and Above

Figures & data

Table 1 Baseline Characteristics

Characteristics	Non-Longevity	Longevity	z	P
N	7093	324	–	–
Male (%)	59.5	27.2	–	–
Height (cm)	162.00 (11.0)	145.00 (11.0)	−25.48	< 0.001
Weight (kg)	62.00 (13.5)	38.00 (11.0)	−27.77	< 0.001
Waist (cm)	80.00 (12.0)	71.00 (13.0)	−15.96	< 0.001
BMI (kg/m^2)	23.66 (3.7)	18.52 (4.5)	−22.68	< 0.001
FPG (mmol/L)	5.00 (0.8)	5.07 (1.9)	−2.12	0.034
SBP (mmHg)	120.00 (22.0)	145.50 (27.0)	−18.62	< 0.001
DBP (mmHg)	77.00 (12.0)	80.00 (18.0)	−5.98	< 0.001
TG (mmol/L)	1.20 (0.7)	1.07 (0.8)	−4.40	< 0.001
TC (mmol/L)	5.15 (1.3)	4.84 (1.5)	−5.29	< 0.001
HDL-C (mmol/L)	1.40 (0.3)	1.41 (0.7)	−0.69	0.490
LDL-C (mmol/L)	2.85 (1.1)	2.80 (0.6)	2.65	0.008

Note: Values are presented as median (IQR).

Abbreviation: IQR, Interquartile Range.

Table 2 The Correlations Between Several Indices and Age

Indices	Age
	r	P
BMI	−0.160	< 0.001
SBP	0.392	< 0.001
DBP	0.111	< 0.001
FPG	0.131	< 0.001
TC	0.070	< 0.001
TG	0.009	0.418
HDL-C	0.056	< 0.001
LDL-C	0.074	< 0.001

Figure 1 Relation between age and the P75 levels of BMI, FPG, BP, BL. (A) The association of age with P75 levels of BMI. The longevity had lower BMI levels; (B and C) The association of age with P75 levels of SBP and DBP. SBP and DBP levels in the longevity subjects were higher than in other subjects; (D) The association of age with P75 levels of FPG. The longevity subjects had higher FPG levels; (E–H) The association of age with P75 levels of TC, TG, HDL-C, and LDL-C. The BL levels were different between longevity people and others.

Table 3 The Distribution of Several Indicators in the Non-Longevity Population and the Longevity Population

Biochemical Indicators		Non-Longevity	Longevity	χ ^2	P
FPG (mmol/L)	< 6.10	6617 (93.3%)	236 (72.8%)	251.68	< 0.001
	6.10–7.00	332 (4.7%)	39 (12.0%)
	≥ 7.00	144 (2.0%)	49 (15.1%)
SBP (mmHg)	< 130.00	4555 (64.2%)	58 (17.9%)	419.95	< 0.001
	130.00–139.00	1209 (17.0%)	57 (17.6%)
	≥ 140.00	1329 (18.7%)	209 (64.5%)
DBP (mmHg)	< 85.00	5583 (78.7%)	209 (64.5%)	42.19	< 0.001
	85.00–89.00	608 (8.6%)	36 (11.1%)
	≥ 90.00	902 (12.7%)	79 (24.4%)
TC (mmol/L)	< 5.20	3674 (51.8%)	199 (61.4%)	12.43	0.002
	5.2–6.2	2264 (31.9%)	77 (23.8%)
	≥ 6.20	1155 (16.3%)	48 (14.8%)
TG (mmol/L)	< 1.70	5418 (76.4%)	253 (78.1%)	7.26	0.027
	1.70–2.30	955 (13.5%)	29 (9.0%)
	≥ 2.30	720 (10.2%)	42 (13.0%)
HDL-C (mmol/L)	< 1.00	52 (0.7%)	52 (16.0%)	525.75	< 0.001
	≥ 1.00	7041 (99.3%)	272 (84.0%)
LDL-C (mmol/L)	< 3.40	5760 (81.2%)	244 (75.3%)	7.97	0.019
	3.40–4.10	976 (13.8%)	55 (17.0%)
	≥ 4.10	357 (5.0%)	25 (7.7%)

Table 4 Reference Interval Values for FPG, BP and BL of Longevity (≥ 90 Years-Old) and Their Standard Values

Indicators		Longevity	Standard Values
FPG (mmol/L)	Desirable level	< 6.15 mmol/L	< 6.10 mmol/L
	Borderline value	6.15–7.45 mmol/L	6.10–7.00 mmol/L
	High value	≥ 7.45 mmol/L	≥ 7.00 mmol/L
SBP (mmHg)	Desirable level	< 160.00 mmHg	< 130.00 mmHg
	Borderline value	160.00–174.50 mmHg	130.00–139.00 mmHg
	High value	≥ 175.00 mmHg	≥ 140.00 mmHg
DBP (mmHg)	Desirable level	< 88.00 mmHg	< 85.00 mmHg
	Borderline value	88.00–90.00 mmHg	85.00–89.00 mmHg
	High value	≥ 90.00 mmHg	≥ 90.00 mmHg
TC (mmol/L)	Desirable level	< 5.59 mmol/L	< 5.20 mmol/L
	Borderline value	5.59–6.45 mmol/L	5.20–6.20 mmol/L
	High value	≥ 6.45 mmol/L	≥ 6.20 mmol/L
LDL-C (mmol/L)	Desirable level	< 3.30 mmol/L	< 3.40 mmol/L
	Borderline value	3.30–3.85 mmol/L	3.40–4.10 mmol/L
	High value	≥ 3.85 mmol/L	≥ 4.10 mmol/L
TG (mmol/L)	Desirable level	< 2.82 mmol/L	< 2.30 mmol/L
	High value	≥ 2.82 mmol/L	≥ 2.30 mmol/L
HDL-C (mmol/L)	Low value	< 0.80 mmol/L	< 1.00 mmol/L
	Desirable level	≥ 0.80 mmol/L	≥ 1.00 mmol/L