Association of Metabolic Syndrome with Aerobic Exercise and LPL rs3779788 Polymorphism in Taiwan Biobank Individuals

Figures & data

Table 1 Demographic Characteristics of Study Participants

	No MetS	MetS	p-value
	(n=6098)	(n=1434)
rs3779788, n (%)			0.5993
CC/CT	5943 (97.46)	1401 (97.70)
TT	155 (2.54)	33 (2.30)
Exercise, n (%)			0.9613
No	4074 (66.81)	959 (66.88)
Aerobic exercise	2024 (33.19)	475 (33.12)
Sex, n (%)			<0.0001
Female	3352 (54.97)	655 (45.68)
Male	2746 (45.03)	779 (54.32)
Age, yr			<0.0001
30–40	1878 (30.80)	226 (15.76)
41–50	1812 (29.71)	365 (25.45)
51–60	1581 (25.93)	507 (35.36)
61–70	827 (13.56)	336 (23.43)
Education, n (%)			<0.0001
University & above	3330 (54.61)	566 (39.47)
Senior High School	1915 (31.40)	509 (35.50)
Junior High School	507 (8.31)	188 (13.11)
Elementary & below	346 (5.67)	171 (11.92)
Marital status, n (%)			<0.0001
Married	4781 (78.40)	1140 (79.50)
Single	706 (11.58)	113 (7.88)
Divorced	391 (6.41)	108 (7.53)
Widowed	220 (3.61)	73 (5.09)
BMI (kg/m^2)			<0.0001
Normal	3440 (56.41)	227 (15.83)
Overweight	1830 (30.01)	488 (34.03)
Obese	828 (13.58)	719 (50.14)
Smoking, n (%)			<0.0001
Never	4793 (78.60)	994 (69.32)
Former	663 (10.87)	199 (13.88)
Current	642 (10.53)	241 (16.81)
Alcohol Drinking, n (%)			<0.0001
Never	5555 (91.10)	1207 (84.17)
Former	139 (2.28)	80 (5.58)
Current	404 (6.63)	147 (10.25)
Midnight snacking, n (%)			0.0118
No	4211 (69.06)	941 (65.62)
Yes	1887 (30.94)	493 (34.38)
Coffee drinking, n (%)			<0.0001
No	4012 (65.79)	1024 (71.41)
Yes	2086 (34.21)	410 (28.59)
Tea drinking, n (%)			0.2507
No	3850 (63.14)	882 (61.51)
Yes	2248 (36.86)	552 (38.49)
Vegetarian diet, n (%)			0.2312
No	5499 (90.18)	1308 (91.21)
Yes	599 (9.82)	126 (8.79)
Dietary fat, mean score (SE)	32.100 ± 0.098	32.645 ± 0.202	0.0153

Note: Data were presented as numbers and percentages. CC/CT and TT are the rs3779788 genotypes.

Abbreviations: MetS, metabolic syndrome; BMI, body mass index; yr, year.

Table 2 Odds Ratios for MetS Among Study Participants

	OR	95% C.I.
rs3779788 (ref: CC/CT)
TT	0.875	0.571–1.341
Exercise (ref: No)
Aerobic exercise	0.858	0.743–0.991
Sex (ref: Female)
Male	0.960	0.817–1.129
Age (ref: 30–40)
41–50	1.634	1.334–2.002
51–60	2.724	2.210–3.358
61–70	3.765	2.960–4.787
Education (ref: University & above)
Senior High School	1.243	1.067–1.448
Junior High School	1.388	1.111–1.732
Elementary & below	1.434	1.118–1.840
Marital status (ref: Married)
Single	1.026	0.804–1.309
Divorced	1.238	0.958–1.958
Widowed	1.016	0.739–1.397
BMI, kg/m^2 (ref: Normal)
Overweight	3.712	3.122–4.414
Obese	13.681	11.464–16.327
Smoking (ref: Never)
Former	0.869	0.702–1.076
Current	1.429	1.154–1.770
Alcohol Drinking (ref: Never)
Former	1.454	1.042–2.030
Current	1.256	0.988–1.598

Note: Adjusted for midnight snacking, coffee and tea consumption, vegetarian diet, and dietary fat.

Abbreviations: MetS, metabolic syndrome; BMI, body mass index; OR, odds ratio; ref, reference.

Table 3 Odd Ratios for MetS Among Individuals with Rs3779788 Genotypes

	CC/CT		TT
	OR	95% C.I.	OR	95% C.I.
Exercise (ref: No)
Aerobic exercise	0.841	0.727–0.974	4.076	1.158–14.346
Sex (ref: Female)
Male	0.986	0.838–1.161	0.105	0.022–0.507
Age (ref: 30–40)
41–50	1.620	1.320–1.988	2.334	0.416–13.092
51–60	2.702	2.187–3.338	3.836	0.624–23.573
61–70	3.639	2.852–4.642	17.570	2.466–125.193
Education (ref: University & above)
Senior High School	1.243	1.065–1.451	1.142	0.331–3.948
Junior High School	1.389	1.110–1.738	2.775	0.375–20.545
Elementary & below	1.487	1.155–1.914	0.731	0.078–6.889
Marital status (ref: Married)
Single	1.006	0.785–1.289	2.369	0.413–13.594
Divorced	1.234	0.954–1.597	1.098	0.086–14.033
Widowed	1.068	0.773–1.475	0.169	0.012–2.368
BMI, kg/m^2 (ref: Normal)
Overweight	3.753	3.149–4.473	2.607	0.740–9.185
Obese	13.684	11.439–16.370	42.519	9.291–194.577
Smoking (ref: Never)
Former	0.857	0.691–1.064	3.021	0.400–22.809
Current	1.399	1.128–1.737	25.386	2.747–234.632
Alcohol Drinking (ref: Never)
Former	1.515	1.082–2.121	0.130	0.005–3.150
Current	1.256	0.984–1.604	0.726	0.100–5.291

Note: Adjusted for midnight snacking, coffee and tea consumption, vegetarian diet, and dietary fat.

Abbreviations: MetS, metabolic syndrome; BMI, body mass index; OR, odds ratio; ref, reference.

Table 4 Odds of Having MetS Based on Aerobic Exercise and Rs3779788 Genotypes

	OR	95% C.I.
Aerobic exercise and rs3779788 (ref: no exercise and CC/CT)
No exercise and TT	0.636	0.366–1.107
Aerobic exercise and CC/CT	0.841	0.727–0.973
Aerobic exercise and TT	1.282	0.659–2.496
Sex (ref: Female)
Male	0.957	0.815–1.125
Age (ref: 30–40)
41–50	1.634	1.334–2.001
51–60	2.722	2.209–3.356
61–70	3.765	2.960–4.789
Education (ref: University & above)
Senior High School	1.243	1.067–1.448
Junior High School	1.395	1.117–1.742
Elementary & below	1.441	1.122–1.850
Marital status (ref: Married)
Single	1.028	0.806–1.312
Divorced	1.236	0.957–1.596
Widowed	1.010	0.734–1.389
BMI, kg/m^2 (ref: Normal)
Overweight	3.720	3.128–4.423
Obese	13.722	11.497–16.377
Smoking (ref: Never)
Former	0.873	0.705–1.081
Current	1.439	1.162–1.783
Alcohol Drinking (ref: Never)
Former	1.467	1.051–2.048
Current	1.257	0.988–1.599

Note: Adjusted for midnight snacking, coffee and tea consumption, vegetarian diet, and dietary fat.

Abbreviations: MetS, metabolic syndrome; BMI, body mass index; OR, odds ratio; ref, reference.