Analysis of Endocrine and Metabolic Indexes in Non-Obese Patients with Polycystic Ovary Syndrome and Its Compare with Obese Patients

Figures & data

Table 1 Comparison of Anthropometric Indexes and Body Composition Between Groups

Indexes	Obese PCOS Group	Normal BMI PCOS Group	Obese Non-PCOS Group	Normal BMI Non-PCOS Group
	(OP, n=79)	(NP, n=40)	(ON, n=30)	(NN, n=30)
BMI	30.55±4.03*	21.99±3.59	31.08±5.79	19.40±5.1.90
Waist circumference	97.91±10.75*	75.22±6.30	98.72±11.39	69.78±5.26
WHR	0.94±0.06*	0.84±0.04	0.92±0.05	0.81±0.03
Visceral fat area	149.53±41.52*	75.63±23.14	141.48±37.81	54.78±22.26

Notes: Data are represented as mean ± standard deviation; *P <0.05.

Abbreviations: PCOS, polycystic ovary syndrome; BMI, body mass index; WHR, waist-to-hip ratio.

Table 2 Comparison of Sex Hormone Between Groups

Indexes	Obese PCOS Group	Normal BMI PCOS Group	Obese Non-PCOS Group	Normal BMI Non-PCOS Group
	(OP, n=79)	(NP, n=40)	(ON, n=30)	(NN, n=30)
SHBG	19.08±12.63*	39.74±22.01	22.61±11.06	44.24±20.85
FAI (%)	18.96±10.66*	8.84±5.73	10.10±6.807**	6.45±4.19
T (ng/mL)	0.78±0.20	0.82±0.27	0.50±0.14**	0.61±0.17^#
LH (mIU/mL)	12.70±6.81*	19.03±13.18	6.45±4.60**	7.08±4.78^#
LH/FSH	2.15±0.90*	2.83±1.76	1.55±0.87**	1.23±0.74^#
AMH (ng/mL)	7.53±3.87	9.11±5.44	4.35±2.77**	5.65±2.34

Notes: Data are represented as mean ± standard deviation; *P <0.05: obese PCOS group and normal BMI PCOS group; **P <0.05: obese PCOS group and obese non-PCOS group; ^# P <0.05: normal BMI PCOS group and normal BMI non-PCOS group.

Abbreviations: PCOS, polycystic ovary syndrome; SHBG, sex hormone binding globulin; FAI, free androgen index; T, testosterone; LH, luteinizing hormone; LH/FSH, luteinizing hormone/follicle stimulating hormone; AMH, anti-Mullerian hormone.

Table 3 Comparison of the Differences of Glucose Metabolic Indexes Between Groups

Indexes	Obese PCOS Group	Normal BMI PCOS Group	Obese Non-PCOS Group	Normal BMI Non-PCOS Group
	(OP, n=79)	(NP, n=40)	(ON, n=30)	(NN, n=30)
0 min PBG (mmol/l)	5.65±0.97	5.17±0.41	5.42±0.48	4.75±0.37^#
60 min PBG (mmol/l)	10.44±2.87	8.66±2.04	9.53±1.42	6.79±1.97^#
120 min PBG (mmol/l)	8.84±2.97	6.90±1.79	7.32±1.15**	5.66±1.57^#
180 min PBG (mmol/l)	6.08±2.91	5.50±1.14	4.85±1.51	4.57±0.83^#
0 min INS (mU/L)	24.13±19.05*	8.22±3.29	17.94±6.82	6.14±2.12^#
60 min INS (mU/L)	126.85±64.22*	78.36±45.99	125.76±61.65	48.78±25.79^#
120 min INS (mU/L)	133.17±76.66*	57.60±29.70	104.37±62.50	34.81±19.17^#
180 min INS (mU/L)	66.56±58.64*	24.45±11.61	47.69±37.07	12.03±8.86^#
HOMA-IR	7.44±7.86*	1.87±0.96	4.33±1.79**	1.31±0.48^#

Notes: Data are represented as mean ± standard deviation; *P <0.05: obese PCOS group and normal BMI PCOS group; **P <0.05: obese PCOS group and obese non-PCOS group; ^# P <0.05: normal BMI PCOS group and normal BMI non-PCOS group.

Abbreviations: PCOS, polycystic ovary syndrome; PBG, postprandial blood glucose; INS, insulin; HOMA-IR, insulin resistance index.

Table 4 Comparison of the Differences of Lipid Metabolic Indexes Between Groups

Indexes	Obese PCOS Group	Normal BMI PCOS Group	Obese Non-PCOS Group	Normal Non-PCOS Group
	(OP, n=79)	(NP, n=40)	(ON, n=30)	(NN, n=30)
TG	1.86±0.93*	0.86±0.45	1.48±1.12	0.80±0.29
TC	4.97±1.09*	4.21±0.77	4.50±0.69**	4.27±0.40
HDL-C	1.07±0.22*	1.43±0.29	1.14±0.26	1.68±0.04
LDL-C	3.26±0.89*	2.38±0.75	2.77±0.51**	2.33±0.79
sd-LDL	1.16±0.53*	0.44±0.23	0.79±0.25	0.55±0.11

Notes: Data are represented as mean ± standard deviation; *P <0.05: obese PCOS group and normal BMI PCOS group; **P <0.05: obese PCOS group and obese non-PCOS group.

Abbreviations: TG, triglyceride; TC, cholesterol; HDL-C, high-density lipoprotein-cholesterol; LDL-C, low-density lipoprotein-cholesterol; sd-LDL, small dense low-density lipoprotein.

Table 5 Correlation Analysis of FAI and T and HOMA-IR, LH, and LH/FSH in the Obese PCOS Group

	HOMA-IR	LH	LH/FSH
FAI	0.338*	0.026	−0.136
T	0.205	0.184	0.033

Note: *P <0.05.

Abbreviations: FAI, free androgen index; T, testosterone; HOMA-IR, insulin resistance index; LH, luteinizing hormone; LH/FSH, luteinizing hormone/follicle stimulating hormone; PCOS, polycystic ovary syndrome.

Table 6 Correlation Analysis of FAI and T and HOMA-IR, LH, and LH/FSH in the Normal BMI PCOS Group

	HOMA-IR	LH	LH/FSH
FAI	0.672*	−0.261	−0.219
T	0.240	−0.203	−0.256

Note: *P <0.01.

Abbreviations: FAI, free androgen index; T, testosterone; HOMA-IR, insulin resistance index; LH, luteinizing hormone; LH/FSH, luteinizing hormone/follicle stimulating hormone; PCOS, polycystic ovary syndrome.

Table 7 Correlation Analysis Between Differential Metabolic Indexes and BMI, Waist Circumference, and Visceral Fat Area

	TC	TG	sd-LDL	HDL-C	LDL-C	0 Min INS	60 Min INS	120 Min INS	180 Min INS
BMI	0.373**	0.284**	0.534**	−0.502**	0.442**	0.360**	0.399**	0.430**	0.318**
Waist circumference	0.288**	0.367**	0.509**	−0.518**	0.369**	0.408**	0.433**	0.508**	0.368**
Visceral fat area	0.142	0.273	0.523	−0.452**	0.259	0.255	0.175	0.393**	0.144

Note: **P <0.01.

Abbreviations: BMI, body mass index; TC, cholesterol; TG, triglyceride; sd-LDL, small dense low-density lipoprotein; HDL-C, high-density lipoprotein-cholesterol; LDL-C, low-density lipoprotein-cholesterol; INS, insulin.

Table 8 Correlation Analysis Between HOMA-IR and BMI, Waist Circumference, Visceral Fat Area, FAI, and SHBG

	r	P
BMI	0.304	0.012
Waist circumference	0.392	0.001
Visceral fat area	0.293	0.048
FAI	0.453	0.000
SHBG	−0.226	0.048

Abbreviations: HOMA-IR, insulin resistance index; BMI, body mass index; FAI, free androgen index; SHBG, sex hormone binding globulin; r, correlation coefficient.