Platelet-to-Lymphocyte Ratio Predicts the Presence of Diabetic Neurogenic Bladder

Figures & data

Table 1 Baseline Patient Characteristics

	DNB (N=115)	T2DM (N=256)	P-value
Sex
Male	34(29.6%)	174(68.0%)	<0.001
Female	81(70.4%)	82(32.0%)
Age	63.3±13.0	55.7±13.2	<0.001
BMI, kg/m2	22.2±3.78	25.2±3.45	<0.001
SBP (mmHg)	136±25.7	136±18.6	0.986
DBP (mmHg)	76.8±14.2	79.9±11.3	0.024
Duration of diabetes (years)	11.4±6.23	6.68±5.90	<0.001
History (%)
Smoking (current or ever)	13 (11.3%)	92 (35.9%)	<0.001
Drinking (current or ever)	7 (6.1%)	66 (25.8%)	<0.001
Comorbidity (%)
Hypertension	70 (60.9%)	115 (44.9%)	0.005
Diabetic nephropathy	33 (28.7%)	5 (2.0%)	<0.001
Atherosclerosis	78 (67.8%)	126 (49.2%)	<0.001
Laboratory data
HbA1c%	9.57±2.61	9.23±2.21	0.503
FBG	9.31±4.71	7.91±3.65	<0.001
RBC	3.78±0.637	4.56±0.605	<0.001
WBC	7.48±3.52	7.08±1.89	0.48
NLR	4.04±3.32	1.91±1.25	<0.001
PLR	175±90.1	89.1±24.6	<0.001
HB	110±23.0	139±18.5	<0.001
Total bilirubin	8.07±3.77	12.1±5.41	<0.001
Direct bilirubin	3.14±1.96	4.48±2.70	<0.001
Indirect bilirubin	4.93±2.30	7.63±3.29	<0.001
Albumin	34.5±6.64	39.3±5.16	<0.001
ALT	21.4±16.8	30.2±22.8	<0.001
AST	24.4±16.4	27.1±15.6	0.002
Blood urea nitrogen	7.70±5.50	5.59±2.15	<0.001
Creatinine	85.2±62.7	67.0±21.6	0.097
Uric acid	300±111	333±96.6	<0.001
TC	4.43±1.70	4.71±1.19	0.003
TG	1.55±1.28	2.21±1.89	<0.001
HDLc	1.10±0.388	0.99±0.236	0.017
LDLc	2.48±1.28	2.59±0.844	0.013
GNRI	93.3±13.6	140±33.7	<0.001

Abbreviations: BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; RBC, red blood cell; WBC, white blood cell; PLR, platelet-to-lymphocyte ratio; TB, total bilirubin; NLR, neutrophil-to-lymphocyte ratio; TG, triglycerides; TC, total cholesterol; GNRI, geriatric nutritional risk index; HB, hemoglobin; FBG, fasting blood glucose.

Table 2 Logistic Regression Analysis Showing Independent Predictors of DNB

Variables	OR	95% CI	p-value
Sex	0.65	0.285–1.485	0.388
Age	0.983	0.946–1.02	0.450
Duration of diabetes	1.127	1.059–1.203	0.002
Atherosclerosis	0.963	0.413–2.227	0.940
BMI	0.903	0.802–1.016	0.155
HbA1c	1.074	0.905–1.284	0.498
HB	0.96	0.936–0.983	0.006
PLR/10	1.408	1.248–1.617	<0.001
NLR	1.206	0.963–1.532	0.184
TB	0.88	0.804–0.958	0.016
FBG	1.051	0.953–1.159	0.397
UA	0.998	0.994–1.002	0.354
GNRI	0.953	0.927–0.972	<0.001

Abbreviations: BMI, body mass index; PLR, platelet-to-lymphocyte ratio; TB, total bilirubin; NLR, neutrophil-to-lymphocyte ratio; GNRI, geriatric nutritional risk index; HB, hemoglobin; UA, uric acid; FBG, fasting blood glucose; OR, odds ratio; CI, confidence interval.

Figure 1 Logistic forest plot showing independent predictors of DNB.

Abbreviations: BMI, body mass index; PLR, platelet-to-lymphocyte ratio; TB, total bilirubin; NLR, neutrophil-to-lymphocyte ratio; GNRI, geriatric nutritional risk index; HB, hemoglobin; UA, uric acid; FBG, fasting blood glucose; OR, odds ratio.

Figure 2 Receiver-operating characteristics (ROC) curve analysis for platelet-to-lymphocyte ratio as a predictor of the severity of diabetic neurogenic bladder.

Abbreviations: ROC, receiver operating characteristic; CI, confidence interval; PLR, platelet-to-lymphocyte ratio.