Association Between Elevated Thyroid Peroxidase Antibody and Abdominal Fat Distribution in Patients with Type 2 Diabetes Mellitus

Figures & data

Table 1 Clinical Characteristics of T2DM Patients with and without Visceral Obesity

Variables	Visceral Obesity (n = 185)	Normal (n = 205)	P value
Age	50.19(36.62–63.76)	52.77(40.47–65.08)	0.05
Duration of T2DM	39(0–122)	37(0–122)	0.68
Female, n	28	85	<0.001*
SBP	132.85(117.65–148.05)	126.90(110.68–143.12)	<0.001*
DBP	81.19(71.46–90.92)	78.27(67.82–88.72)	0.005*
BMI	26.73(23.26–30.20)	23.02(20.40–25.65)	<0.001*
WC	96.58(86.36–106.80)	85.48(77.01–93.95)	<0.001*
HbA1c	9.20(7.06–11.35)	9.32(6.97–11.66)	0.622
FPG	7.23(4.35–10.11)	6.94(4.17–9.72)	0.316
HOMA-IR	2.2(1–3.9)	1.5(0.6–2.85)	<0.001*
TG	1.72(1.29–2.61)	1.31(0.94–1.97)	<0.001*
TC	4.99(3.47–6.51)	4.82(2.95–6.69)	0.325
LDL-C	2.81(1.95–3.67)	2.73(1.89–3.58)	0.367
HDL-C	0.97(0.75–1.20)	1.08(0.83–1.33)	<0.001*
ALT	35(22–57.5)	22(15–35)	<0.001*
AST	34.27(12.25–56.29)	24.46(8.67–40.25)	<0.001*
γGT	35(25–67)	27(18–39)	<0.001*
UA	365.29(273.61–456.97)	310.50(234.33–386.67)	<0.001*
WBC	6.89(4.96–8.83)	6.44(4.85–8.04)	0.013*
Hcy	14.10(7.68–20.53)	12.01(9.48–14.53)	<0.001*

Note: *p value less than 0.05.

Table 2 Comparison of Thyroid Indicators of T2DM Patients with and without Visceral Obesity

Variables	Visceral Obesity (n = 185)	Normal (n = 205)	P value
TPOAb(+), n (%)	24(12.97%)	11(5.37%)	0.009*
TGAb(+), n (%)	12(6.49%)	9(4.39%)	0.360
TPOAb and TGAb(+), n (%)	9(4.87%)	4(1.95%)	0.154
TSH	1.90(0.94–2.86)	1.70(0.77–2.63)	0.032*
FT3	3.17(2.74–3.61)	3.05(2.64–3.46)	0.004*
FT4	9.50(8.04–10.96)	9.38(7.70–11.06)	0.443

Note: *p value less than 0.05.

Table 3 Association of TPOAb and VFA with Other Indicators in T2DM Patients

	TPOAb		VFA
	R value	P value	R value	P value
Age	−0.037	0.467	−0.129	0.011*
Gender	0.035	0.494	−0.291	<0.001*
Duration of T2DM	−0.058	0.255	−0.084	0.099
VFA	0.175	0.001*	Null	Null
SFA	0.184	<0.001*	0.731	<0.001*
TPOAb	Null	Null	0.175	0.001*
TSH	0.199	<0.001*	0.145	0.004*
FT3	0.073	0.152	0.179	<0.001*
FT4	−0.113	0.025*	0.021	0.677
HOMA-IR	0.016	0.759	0.236	<0.001*

Note: *p value less than 0.05.

Figure 1 Association between TPOAb titer and VFA. Linear correlation analysis showed an obviously positive correlation of VFA with TPOAb titer in T2DM patients (r = 0.175, p < 0.001).

Figure 2 Association between TPOAb titer and SFA. Linear correlation analysis showed an obviously positive correlation of SFA with TPOAb titer in T2DM patients (r = 0.184, p < 0.001).

Table 4 Association of the TPOAb with Visceral Fat Area: Binary Logistic Regression

Variables	B	OR	P value	95% Confidence Interval
				Lower Limit	Upper Limit
Age	0.013	1.013	0.298	0.989	1.037
Gender	−1.077	0.341	0.001*	0.181	0.641
Duration of T2DM	0.003	1.003	0.188	0.999	1.006
TSH	0.193	1.213	0.176	0.917	1.604
FT3	0.464	1.590	0.178	0.809	3.125
FT4	0.115	1.122	0.210	0.937	1.342
TPOAb	1.449	4.258	0.004*	1.594	11.375
TG	0.113	1.120	0.107	0.976	1.285
TC	−0.036	0.965	0.717	0.795	1.171
HOMA-IR	0.085	1.089	0.016*	1.016	1.167
HbA1c	−0.020	0.980	0.753	0.864	1.111
WC	0.144	1.155	<0.001*	1.113	1.199

Note: *p value less than 0.05.