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ORIGINAL RESEARCH

MAFLD is Associated with the Risk of Liver Fibrosis and Inflammatory Activity in HBeAg-Negative CHB Patients

ORCID Icon, , , &
Pages 673-683 | Published online: 01 Mar 2022

Figures & data

Table 1 Comparison of Clinical Characteristics of CHB with and without MAFLD, Stratified by HBeAg Status

Table 2 Comparison of Pathological Characteristics of CHB with and without MAFLD, Stratified by HBeAg Status

Figure 1 Comparison of liver activity score and fibrosis stage distributions between MAFLD-CHB and non-MAFLD-CHB groups under the NASH CRN system, stratified by HBeAg status (A) Comparison of liver activity score distribution; (B) Comparison of liver fibrosis stage distribution; (C) Comparison of proportion of A ≥3; (D) Comparison of proportion of F ≥2; MAFLD-CHB, defined as patients fulfilling the criteria for both MAFLD and CHB; Non-MAFLD-CHB, defined as patients who met the diagnostic criteria for CHB but did not meet the diagnostic criteria for MAFLD.

Abbreviations: MAFLD, metabolic associated fatty liver disease; CHB, chronic hepatitis B; NASH CRN, the Nonalcoholic Steatohepatitis Clinical Research Network; HBeAg, hepatitis B e antigen; A, liver activity score; F, fibrosis stages; *p < 0.05, **p < 0.01, and ***p < 0.001.
Figure 1 Comparison of liver activity score and fibrosis stage distributions between MAFLD-CHB and non-MAFLD-CHB groups under the NASH CRN system, stratified by HBeAg status (A) Comparison of liver activity score distribution; (B) Comparison of liver fibrosis stage distribution; (C) Comparison of proportion of A ≥3; (D) Comparison of proportion of F ≥2; MAFLD-CHB, defined as patients fulfilling the criteria for both MAFLD and CHB; Non-MAFLD-CHB, defined as patients who met the diagnostic criteria for CHB but did not meet the diagnostic criteria for MAFLD.

Table 3 Univariate Analysis of Factors Associated with Moderate-to-Severe Liver Activity (A ≥3) and Significant Fibrosis (F ≥2) in Patients with CHB

Table 4 Multivariate Analysis of Factors Associated with Moderate-to-Severe Liver Activity (A≥3) in Patients with CHB and Stratified by HBeAg Status

Table 5 Multivariate Analysis of Factors Associated with Significant Fibrosis (F≥2) in Patients with CHB and Stratified by HBeAg Status