Fibrosis Predictive Score in Caucasian Patients with Metabolic Syndrome

Figures & data

Figure 1 Mild steatosis (S1) bright liver with discrete posterior attenuation.

Figure 2 Moderate steatosis (S2) bright liver with obvious posterior attenuation.

Figure 3 Severe steatosis (S3) bright liver with intense posterior.

Table 1 Baseline Characteristics of the Study Group

Parameter	Study Group (179 pts)
Age, years^a	63± 11
Gender: male/female^b	90 (50.3%)/89 (49.7%)
BMI (kg/m^2)^c	32 [29–36]
Waist circumference (cm)^c	110 [100–120]
sBP (mmHg)^c	140 [130–155]
dBP (mmHg)^c	80 [76–90]
HR (b/min)^a	76 ± 11
HDL (mg/dL)^c	45 [38–53]
Triglycerides (mg/dL)^c	152 [101–197]
Fasting glucose (mg/dL)^c	110 [99–133]
OGTT (mg/dL)^c	136 [128–155]
Diabetes Mellitus^c	71 (39.7%)
NT-proBNP^c	60 [60–92]
Serum Albumin (mg/dL)^c	64 [61–67]
Serum Ferritin level (ng/mL)^c	157 [118–241]
PCR-hs > 9mg/L^b	19 (10.6%)
TSH µUI/mL^c	2 [1.4–2.9]
GOT IU/L^c	28 [24–38]
GPT IU/L^c	27 [20–32]
LVEF (%)^b	50 [45–55]
CAP db/m^c	303 [270–345]

Notes:^a mean, standard deviation;^b number, relative frequency;^c median, interquartile range;

Abbreviations: BMI, Body Mass Index; sBP/dBP, systolic/diastolic Blood Pressure; HR, heart rate; HDL, high density lipoprotein; NT-proBNP, N-terminal pro b-type natriuretic peptide; PCR-hs-, high-sensitivity C-reactive protein; TSH, thyroid stimulating hormone; AST, Aspartate transaminase; ALT, Alanine transaminase; OGTT, Oral Glucose Tolerance Test; LVEF, Left ventricle ejection fraction; CAP, Controlled Attenuation Parameter.

Table 2 Logistic Regression for Predicting Liver Fibrosis (>8.2kpa)

Element	B	S.E.	p	OR	95% CI for OR
BMI	0.108	0.039	0.006	1.114	1.031	1.203
HDL	−0.33	0.018	0.050	0.934	0.901	0.967
Hepatic steatosis	0.423	0.244	0.043	1.527	1.236	1.817
Female gender	0.829	0.426	0.032	2.290	1.171	3.461

Notes: The numbers in bold represent the risk for developing at least significant fibrosis for each parameter.

Abbreviations: B, beta coefficient; S.E, standard error; OR, Odd ratio; 95% CI for OR, 95% confidence interval for odd ratio; BMI, Body Mass Index; HDL, high density lipoprotein.

Table 3 Ultrasound Liver Steatosis Accuracy versus CAP Assessment

Ultrasonographic Assessment of Steatosis	CAP Measurements
	≤288 dB/m	>288 dB/m
Mild steatosis	42 (72.4%)	16 (27.6%)
Moderate and Severe steatosis	25 (20.8%)	95 (79.2%)

Abbreviations: CAP, Controlled Attenuation Parameter; db/m, decibel/meter.

Table 4 Hepatic Fibrosis Score (HFS)

Element	Points
BMI > 31.4kg/m^2	1
Female Gender	1
Hepatic steatosis
- mild	1
- moderate	1.5
- severe	2
HDL < 47mg/dL	1

Abbreviations: BMI, Body Mass Index; HDL, high density lipoprotein.

Figure 4 ROC curve of hepatic fibrosis score.

Abbreviations: AUROC, Area Under the Receiver Operating Characteristic; CI, Confidence Interval.