HTR1A Gene Polymorphism in Type 2 Diabetes Mellitus Comorbid with Major Depressive Disorder in a Chinese Population

Figures & data

Table 1 The Demographic Characteristics of T2DM Patients

Variables	Group	NDDM	DDM	χ^2	p
ALL		640 (73.2%)	234 (26.8%)
Gender	Male	430 (80.2%)	106 (19.8%)		4.02×10^−9
	Female	210 (62.1%)	128 (37.9%)
Age		58±12.34	62±11.62		0.017
	Male	56	63		0.09
	Female	62	60
Education level	Primary school	96 (64%)	54 (36%)	13.63	0.001
	Middle school	374 (72.6%)	141 (27.4%)
	College	170 (81.3%)	39 (18.7%)
Marital status	Single	16 (59.3%)	11 (40.7%)	18.56	0.0003
	Married	609 (75.6%)	197 (24.4%)
	Divorced	5 (38.5%)	8 (61.5%)
	Widowed	15 (53.6%)	13 (46.4%)

Note: Bold figures indicates p-value less than 0.05.

Table 2 The Clinical Characteristics of DDM and NDDM Groups

Variables	NDDM	DDM	χ2	p
All	640	234
Diabetes Duration (year)	7.86 ± 6.73	9.30 ± 7.15		0.006
HbA1c (%)	7.35 ± 2.57	7.79 ± 1.02		0.01
HbA1c <7%	378 (59.1%)	111 (47.4%)	9.40	0.002
HbA1c ≥7%	262 (40.9%)	123 (52.6%)
FBG (mmol/L)	7.9 ± 0.2	9.5 ± 0.2		3.075×10-9
BMI (kg/m2)	26.09 ± 3.47	25.58 ± 3.73		0.6
BMI (kg/m2)
<24	176 (27.5%)	72 (30.8%)	0.901	0.342
≥24	464 (72.5%)	162 (69.2%)
Hypertension	374/640 (58.4%)	158/234 (67.5%)	5.936	0.015
Diabetic complications	449/640 (70.2%)	167/234 (71.4%)	0.121	0.728
Neuropathy	433/640 (67.7%)	157/234 (67.1%)	0.025	0.875
Retinopathy	89/640 (13.9%)	195/234 (83.3%)	376.526	7.102×10-84
Nephropathy	82/640 (12.8%)	49/234 (20.9%)	8.883	0.003
Diabetic foot	9/640 (1.4%)	5/234 (1.6%)	0.580	0.446
Number of complications	2.23±1.38	2.45±1.35		0.042

Note: Bold figures indicates p-value less than 0.05.

Table 3 The Primary Information of HTR1A SNPs

SNP	Chr	Location	Alleles	MAF for CHB	MAF in Our Study	p value for HWE
rs878567	5	3’-UTR	A>C, G	0.173	0.218	0.793
rs1800044	5	nonsynon_exon1	C>A	0.000	0.001	1
rs6295	5	5’-flanking	C>G	0.216	0.261	0.678

Table 4 Allele and Genotype Association Analysis of the Three SNPs in HTR1A

SNP	Group	Allele		p	OR [95% CI]	Genotype			p
rs878567		G	A			G/G	G/A	A/A
	NDDM	0.782	0.218	0.1771	0.844 (0.66–1.08)	0.607	0.350	0.043	0.150
	DDM	0.752	0.248			0.579	0.346	0.075
rs1800044		C	A			C/C	C/A	A/A
	NDDM	0.998	0.002	0.384	NA (NA–NA)	0.988	0.003	0	0.384
	DDM	1	0			1	0	0
rs6295		G	C			G/G	G/C	C/C
	NDDM	0.737	0.263	0.1174	0.831 (0.66–1.05)	0.539	0.396	0.065	0.062
	DDM	0.7	0.3			0.513	0.375	0.113

Table 5 Logistic Regression Analysis of the Associations Between Clinical Factors and Risk of DDM

Variables	Crude OR (95% CI)	p	Adjusted OR (95% CI)	p
Female sex	2.46 (1.81–3.42)	9.6×10^–9	2.332 (1.69–3.22)	2.42×10^−7
Age	1.03 (1.01–1.04)	0.00006	1.02 (1.00–1.03)	0.037
Duration of the disease	1.03 (1.00–1.05)	0.006	1.01 (0.98–1.04)	0.470
Hypertension	1.45 (1.06–2.00)	0.021	0.96 (0.60–1.53)	0.864
Presence of complications	1.06 (0.76–1.47)	0.744	0.566 (0.27–1.19)	0.132
Number of complications	1.12 (1.00–1.25)	0.042	1.28 (0.97–1.71)	0.087
FBG level	1.02 (0.98–1.06)	0.256	1.06 (1.00–1.11)	0.040
HbA1c level	1.00 (0.94–1.07)	0.896	0.96 (0.88–1.04)	0.312

Note: Bold figures indicates p-value less than 0.05.