The Elevation of Pancreatic Enzymes in Serum and Their Distribution at Different Stages of Renal Insufficiency Among Diabetic Patients Attending Goba Referral Hospital

Figures & data

Table 1 Stages of CKD by Using GFR

GFR Category	GFR (mL/min/1.73 m^2)	Description
G1	≥ 90	Normal or high
G2	60–89.99	Mildly decreased
G3a	45–59.99	Mildly to moderately decreased
G3b	30–44.99	Moderately to severely decreased
G4	15–29.99	Severely decreased
G5	< 15	Kidney failure

Abbreviations: CKD, Chronic Kidney Disease; GFR, Glomerular Filtration Rate.

Table 2 Frequency and Distribution of GFR Category Among Diabetic Patients Attending Goba Referral Hospital

GFR Category	Frequency Number (%)
G1 (Normal or high)	99 (34.6%)
G2 (Mildly decreased)	139 (48.6%)
G3a (Mildly to moderately decreased)	27 (9.4%)
G3b (Mildly to moderately decreased)	17 (5.9%)
G4 (Severely decreased)	4 (1.4%)
G5 (Kidney failure)	0

Table 3 Mean and SD of Serum Amylase and Lipase at Different Stages of CKD Among Diabetic Patients Attending Goba Referral Hospital

GFR Category	Serum Amylase (IU/L)		Serum Lipase (IU/L)
	Mean ± SD	95% CI	Mean ± SD	95% CI
G1 (n = 99)	57.25 ± 40.23	49.71–65.37	45.83 ± 53.45	36.38–56.66
G2 (n = 139)	46.60 ± 23.21	43.09–50.63	38.77 ± 29.95	34.13–44.10
G3a (n = 27)	46.81 ± 32.23	35.77–59.82	45.34–61.39	24.54–71.57
G3b (n = 17)	106.79 ± 118.18	56.04–164.23	105.07 ± 127.54	49.94–168.02
G4 (n = 4)	104.85 ± 90.42	36.43–211.57	106.98 ± 88.35	25.86–202.37

Abbreviations: CKD, Chronic Kidney Disease; GFR, Glomerular Filtration Rate; SD, Standard Deviation; IU/L, International Unit per Liter.

Table 4 Descriptive Statistics of Pancreatic Enzyme Abnormalities at Different Stages of Renal Insufficiency Among Diabetic Patients Attending Goba Referral Hospital

Serum Enzyme Activity		GFR Category n (%)
Category	Sub-Category	G1 n (%)	G2 n (%)	G3a n (%)	G3b n (%)	G4 n (%)	Total n (%)
Serum amylase	Decreased	14 (4.9)	30 (10.5)	7 (2.4)	5 (1.7)	0 (0)	56 (19.6%)
	Normal	73 (25.5)	104 (36.4)	17 (5.9)	6 (2.1)	2 (0.7)	202 (70.6%)
	Increased	12 (4.2)	5 (1.7)	3 (1.0)	4 (1.4)	2 (0.7)	26 (9.1%)
	Increased > 3X ULN	0 (0)	0 (0)	0 (0)	2 (0.7)	0 (0)	2 (0.7)
Serum lipase	Decreased	15 (5.2)	27 (9.4)	8 (2.8)	5 (1.7)	0 (0)	55 (19.2%)
	Normal	73 (25.5)	94 (32.9)	14 (4.9)	4 (1.4)	2 (0.7)	187 (65.4%)
	Increased	7 (2.4)	17 (5.9)	3 (1.0)	4 (1.4)	1 (0.3)	32 (11.2%)
	Increased > 3X ULN	4 (1.4)	1 (0.3)	2 (0.7)	4 (1.4)	1 (0.3)	12 (4.2%)

Abbreviations: GFR, Glomerular Filtration Rate; ULN, Upper Limit of Normal range.