The Correlation Between Estimated Glucose Disposal Rate and Coagulation Indexes in Type 2 Diabetes Mellitus

Figures & data

Table 1 Clinical Characteristics of All Participants

	Subjects (N=948)
Gender	Female (539, 56.86%)
Age (years)	58.00 (49.00, 67.00)
DM duration (years)	8.00 (2.00, 15.00)
BMI (Kg/m^2)	26.03 (23.91, 28.38)
ALT (U/L)	19.00 (13.90, 27.30)
AST (U/L)	19.50 (16.00, 24.20)
TC (mmol/L)	4.61 (3.82, 5.34)
TG (mmol/L)	1.47 (1.05, 2.24)
LDL-C (mmol/L)	3.02 (2.40, 3.60)
HDL-C (mmol/L)	1.04 (0.89, 1.22)
Scr (mmol/L)	64.60 (55.00, 74.70)
BUN (mmol/L)	5.40 (4.50, 6.50)
FBG (mmol/L)	8.00 (6.28, 10.34)
HbA1c (%)	8.70 (7.30, 10.40)
PT (s)	10.60 (10.10, 11.00)
APTT (s)	25.80 (24.50, 27.10)
FIB (g/L)	2.84 (2.43, 3.35)
eGDR	6.63 (4.51, 8.32)

Note: Data are median (25th–75th interquartile range).

Abbreviations: BMI, Body mass index; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TC, total cholesterol; TG, triglyceride; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; FBG, fasting blood glucose; Scr, Scrum creatinine; BUN, Urea nitrogen; HbA1c, glycated hemoglobin; PT, Prothrombin time; APTT, activated partial thromboplastin time; FIB, fibrinogen; eGDR, estimated glucose disposal rate.

Figure 1 Comparison of coagulation indexes between low eGDR group and high eGDR group. (A) Comparison of the levels of PT between low eGDR group and high eGDR group. (B) Comparison of the levels of APTT between low eGDR group and high eGDR group. (C) Comparison of the levels of FIB between low eGDR group and high eGDR group.

Table 2 Comparison of Indicators Between the Low eGDR and High eGDR Groups

	High eGDR (N=363)	Low eGDR(N=585)	P
Gender	Male (155, 42.70%)	Male (254, 43.42%)	0.840
Age (years)	60.00 (51.00,67.00)	58.00 (48.00,67.00)	0.052
DM duration (years)	10.00 (4.00,15.00)	7.00 (1.00,15.00)	<0.001*
BMI (Kg/m^2)	24.84 (23.13,27.05)	26.80 (24.38,29.35)	<0.001*
ALT (U/L)	18.30 (14.13,25.80)	19.30 (15.70,25.10)	0.267
AST (U/L)	19.65 (16.40,23.60)	19.30 (15.70,25.10)	0.863
TC (mmol/L)	4.33 (3.67,5.12)	4.75 (3.88,5.58)	<0.001*
TG (mmol/L)	1.26 (0.90,1.95)	1.57 (1.10,2.30)	<0.001*
LDL-C (mmol/L)	2.85±0.82	3.16±0.84	<0.001*
HDL-C (mmol/L)	1.06 (0.89,1.23)	1.04 (0.89,1.21)	0.270
Scr (mmol/L)	65.25 (56.10,75.98)	63.80 (54.45,74.10)	0.256
BUN (mmol/L)	5.40 (4.60,6.58)	5.30 (4.40,6.50)	0.407
FBG (mmol/L)	7.05 (5.50,8.42)	8.88 (6.84,11.40)	<0.001*
HbA1c (%)	7.60 (6.60,8.60)	9.70 (8.10,11.13)	<0.001*
PT (s)	10.65 (10.30,11.10)	10.50 (10.00,11.00)	0.006*
APTT (s)	25.95 (24.80,27.50)	25.70 (24.30,26.80)	<0.001*
FIB (g/L)	2.77 (2.37,3.24)	2.83 (2.47,3.41)	0.035*

Notes: Data are median (25th–75th interquartile range) and mean ± standard deviation. *Denotes significance at a P value of <0.05.

Abbreviations: BMI, Body mass index; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TC, total cholesterol; TG, triglyceride; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; FBG, fasting blood glucose; Scr, Scrum creatinine; BUN, Urea nitrogen; HbA1c, glycated hemoglobin; PT, Prothrombin time; APTT, activated partial thromboplastin time, FIB, fibrinogen; eGDR, estimated glucose disposal rate.

Figure 2 Comparison of coagulation indexes between male group and female group. (A) Comparison of the levels of PT between male group and female group. (B) Comparison of the levels of APTT between male group and female group. (C) Comparison of the levels of FIB between male group and female group.

Table 3 Comparison of Indicators Between the Male and Female Groups

	Female (N=539)	Male (N=409)	P
Age (years)	61.00 (52.00,68.00)	56.00 (47.00,66.00)	<0.001*
DM duration (years)	10.00 (2.00,16.00)	7.00 (2.00,13.00)	0.034*
BMI (Kg/m^2)	25.91 (23.63,28.45)	26.24±3.25	0.452
ALT (U/L)	17.85 (13.40,25.30)	19.60 (16.10,24.10)	0.004*
AST (U/L)	19.50 (15.90,24.30)	19.60 (16.100,24.10)	0.640
TC (mmol/L)	4.78 (3.98,5.63)	4.45 (3.70,5.23)	<0.001*
TG (mmol/L)	1.58 (1.14,2.30)	1.38 (0.98,2.16)	0.001*
LDL-C (mmol/L)	3.14 (2.54,3.78)	2.94±0.87	<0.001*
HDL-C (mmol/L)	1.09 (0.94,1.26)	1.01 (0.86,1.18)	<0.001*
Scr (mmol/L)	58.00 (49.65,69.45)	67.90 (59.90,77.10)	<0.001*
BUN (mmol/L)	5.30 (4.40,6.50)	5.40 (4.60,6.50)	0.098
FBG (mmol/L)	8.12 (6.47,10.37)	7.89 (6.17,10.25)	0.234
HbA1c (%)	8.80 (7.50,10.20)	8.60 (7.20,10.50)	0.388
PT (s)	10.50 (10.00,10.90)	10.60 (10.10,11.10)	0.062
APTT (s)	25.34±2.14	26.10 (25.00,27.40)	<0.001*
FIB (g/L)	2.94 (2.53,3.39)	2.74 (2.36,3.22)	<0.001*
eGDR	6.53 (4.38,8.30)	6.74 (4.88,8.36)	0.238

Notes: Data are median (25th–75th interquartile range) and mean ± standard deviation. *Denotes significance at a P value of <0.05.

Abbreviations: BMI, Body mass index; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TC, total cholesterol; TG, triglyceride; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; FBG, fasting blood glucose; Scr, Scrum creatinine; BUN, Urea nitrogen; HbA1c, glycated hemoglobin; PT, Prothrombin time; APTT, activated partial thromboplastin time, FIB, fibrinogen; eGDR, estimated glucose disposal rate.

Table 4 The Correlation of eGDR and Coagulation Indexes in Patients with T2DM

	All Patients		Male Patients		Female Patients
	eGDR		eGDR		eGDR
	r	P	r	P	r	P
PT	0.064	0.050	0.045	0.300	0.086	0.083
APTT	0.142	<0.001*	0.173	<0.001*	0.097	0.050
FIB	−0.082	0.012*	−0.093	0.031*	−0.059	0.240

Note: *Denotes significance at a P value of <0.05.

Abbreviations: PT, Prothrombin time; APTT, activated partial thromboplastin time; FIB, fibrinogen; eGDR, estimated glucose disposal rate.

Figure 3 Spearman correlation coefficient matrix illustrating the association between coagulation indexes and baseline patient characteristics in all patients with T2DM.

Figure 4 Spearman correlation coefficient matrix illustrating the association between coagulation indexes and baseline patient characteristics in male patients with T2DM.

Figure 5 Spearman correlation coefficient matrix illustrating the association between coagulation indexes and baseline patient characteristics in female patients with T2DM.