Effect of Genetic Variations in the ADIPOQ Gene on Susceptibility to Type 2 Diabetes Mellitus

Figures & data

Table 1 Demographic Data of T2DM and Healthy Controls

	T2DM Patients (n=96)	Healthy Controls (n=96)	P-value
Age (years)	58.61±5.66	56.54±5.57	0.01
Gender (F:M)	39 (40.6%)	28 (29.2%)	–
	57 (59.4%)	68 (70.8%)
Weight (kg)	73.46±11.23	64.61±11.34	0.0001
Height (cm)	158.91±7.87	157.2±6.38	0.99
BMI (kg/m^2)	29.15±4.41	26.03±3.89	0.0005
Waist Circumference (cm)	93.36±8.01	87.42±6.76	<0.0001
FBG (mmol/L)	6.01±2.23	3.81±0.61	<0.0001
PPBG (mmol/L)	9.18±16.91	5.16±10.19	0.04
Hb1Ac (%)	7.87±0.76	5.41±0.45	<0.0001
Systolic Blood Pressure (mmHg)	129.13±14.42	119.11±16.43	0.001
Diastolic Blood Pressure (mmHg)	79.47±9.75	78.42±8.29	0.42
HDLC (mmol/L)	0.66±0.25	0.55±0.30	0.002
LDLC (mmol/L)	3.72±0.97	2.61±0.76	<0.0001
Total Cholesterol (mmol/L)	4.96±1.31	4.61±1.21	0.056
Triglycerides (mmol/L)	1.66±0.84	1.52±0.72	0.21

Table 2 HWE Analysis for rs17846866 and rs1501299 SNPs in ADIPOQ Gene

SNPs	Minor Allele	p^2	2pq	q^2	X^2	HW p-value
rs17846866	G	0.703	0.271	0.026	1.38	0.23
rs1501299	C	0.305	0.495	0.201	23.47	0.0001

Table 3 Genotype and Allele Frequencies of rs17846866 and rs1501299 SNPs in the ADIPOQ Gene Were Compared Between T2DM and Healthy Controls

Genotypes/Allele (rs17846866)	T2DM (n=96)	Controls (n=96)	ORs	95% CI	p-value
TT (Genotype)	50 (52.1%)	69 (71.9%)
TG (Genotype)	32 (33.4%)	23 (23.9%)	1.92	1.01–3.66	0.04
GG (Genotype)	14 (14.5%)	04 (4.2%)	4.83	1.50–15.55	0.004
TG+GG vs TT (Dominant Model)	46 (47.9%)	27 (28.1%)	2.35	1.29–4.27	0.004
TT+GG vs TG (Co-Dominant Model)	64 (66.6%)	73 (76.1%)	0.63	0.33–1.18	0.15
TT+TG vs GG (Recessive Model)	82 (85.5%)	92 (95.8%)	0.25	0.08–0.80	0.01
T (allele)	132 (0.68)	161 (0.84)
G (allele)	60 (0.32)	31 (0.16)	2.36	1.44–3.85	0.0005
Genotypes/Allele (rs1501299)
AA (Genotype)	19 (19.8%)	41 (42.7%)
AC (Genotype)	40 (41.7%)	24 (25%)	3.59	1.71–7.56	0.0005
CC (Genotype)	37 (38.5%)	31 (32.3%)	2.57	1.24–5.31	0.009
AC+CC vs AA (Dominant Model)	77 (80.2%)	55 (57.3%)	3.02	1.58–5.75	0.0006
AA+CC vs AC (Co-Dominant Model)	56 (58.3%)	72 (75%)	0.46	0.25–0.86	0.01
AA+AC vs CC (Recessive Model)	59 (61.5%)	65 (67.7%)	0.76	0.42–1.37	0.36
A (allele)	78 (0.41)	106 (0.55)
C (allele)	114 (0.59)	86 (0.45)	1.83	1.22–2.74	0.003

Table 4 One-Way Anova Analysis Studies in Diabetes Patients

	+10211TT (n=50)	+10211TG (n=32)	+10211GG (n=14)	p-value	+276AA (n=19)	+276AC (n=40)	+276CC (n=37)	p-value
Age (years)	58.66±5.39	58.75±6.46	58.14±4.95	0.94	57.47±4.47	58.62±6.41	59.15±5.47	0.58
Weight (kg)	72.01±13.05	75.09±8.71	74.98±9.03	0.41	73.23±14.39	76.23±9.43	71.01±10.78	0.12
Height (cm)	158.54±8.64	160.47±7.36	156.68±5.49	0.29	157.86±8.78	159.32±7.43	159.03±7.98	0.79
BMI (kg/m^2)	28.70±5.15	29.22±3.32	30.58±3.52	0.37	29.28±4.70	30.11±3.87	28.19±4.63	0.15
Waist Circumference (cm)	93.44±8.05	94.00±8.19	91.64±7.65	0.65	90.84±6.83	94.18±8.01	93.8±8.43	0.30
HbA1c (%)	7.94±0.82	7.81±0.74	7.75±0.56	0.61	7.8±0.77	7.82±0.76	7.93±0.75	0.76
FBG (mmol/L)	5.83±2.10	6.25±2.44	6.03±2.24	0.70	6.54±2.46	5.81±1.76	5.93±2.49	0.48
PPBG (mmol/L)	10.96±23.30	7.41±2.26	6.85±1.95	0.56	7.31±1.35	7.69±2.48	11.45±26.09	0.52
HDLC (mmol/L)	0.67±0.25	0.65±0.24	0.63±0.26	0.84	0.63±0.22	0.69±0.25	0.64±0.26	0.57
LDLC (mmol/L)	3.94±1.07	3.49±0.77	3.42±0.85	0.055	3.66±1.08	3.49±0.75	3.95±1.06	0.10
Total Cholesterol (mmol/L)	1.63±0.88	1.72±0.86	1.65±0.67	0.89	5.01±1.38	4.92±0.96	4.97±1.54	0.96
Triglycerides (mmol/L)	5.13±1.48	4.79±0.99	4.72±1.23	0.39	1.73±1.08	1.67±0.97	1.62±0.56	0.90