The Correlation Between Angiopoietin-Like 3 and Metabolic Markers of Some Lipid and Glucose in Type 2 Diabetes Mellitus Patients at the First Diagnosis

Figures & data

Table 1 Characteristics of Research Subjects

Characteristics	Control Group (n =98)	Patient Group (n =103)	p
Gender
Male (n, %)	59 (60.2%)	66 (64.1%)	> 0.05*
Female (n, %)	39 (39.8%)	37 (35.9%)
Age (mean ± SD, year)	50.71 ± 6.36	52.51 ± 9.26	>0.05*
Systolic blood pressure (mean ± SD, mmHg)	116.38± 5.2	127.52 ± 12.68	0.000**
Diastolic blood pressure (mean ± SD, mmHg)	71.22 ± 6.05	79.51 ± 10.37	0.000**
BMI (mean ± SD, kg/m^2)	21.58 ± 0.84	23.493 ± 1.18	0.000**
Fasting blood glucose (mean ± SD, mmol/l)	4.94 ± 0.38	12.82 ± 3.66	0.000**
HbA1C (mean ± SD, %)	4.98 ± 0.36	9.76 ± 2.17	0.000**
Total cholesterol (mean ± SD, mmol/L)	4.67 ± 0.34	5.59 ± 1.27	0.000**
HDL-C (mean ± SD, mmol/L)	1.31 ± 0.20	1.11 ± 0.2	0.000**
LDL-C (mean ± SD, mmol/L)	2.22 ± 0.21	3.47 (2.44–4.09)	0.000***
Triglycerid (mean ± SD, mmol/L)	1.18 ± 0.29	2.67 (1.54–4.21)	0.000***
Insulin (mean ± SD, mIU/L)	6.01 (4.32–6.87)	6.37 (4.67–7.92)	0.024***
HOMA-IR	1.32 (0.92–1.56)	3.56 (2.51–4.6)	0.000***
Ure (mean ± SD, mmol/L)	4.79 ± 1.09	5.48 ± 0.83	0.000**
Creatinin (mean ± SD, µmol/L)	76.44 ± 15.04	78.96 ± 13.18	0.208**
Acid uric (mean ± SD, µmol/L)	317.19 ± 60.16	328.61 ± 61.17	0.172**
GOT (mean ± SD, U/L)	20.95 (13.98–33.88)	23.6 (18.7–32.45)	0.002***
GPT (mean ± SD, U/L)	18.29 (18.24–23.57)	29.3 (20.09–44.51)	0.000***
GGT (mean ± SD, U/L)	23.02 (17.64–32.78)	46.49 (37.36–98.56)	0.000***
White blood cells (mean ± SD, G/L)	6.39 ± 1.37	7.66 ± 2.09	0.000**
Red blood cells (mean ± SD, G/L)	4.6 ± 0.35	4.92 ± 0.51	0.000**
Hemoglobin (g/L)	140.22 ± 11.29	146.53 ± 12.43	0.000**
Hematocrit (mean ± SD, L/L)	0.42 ± 0.03	0.43 ± 0.03	0.008**
Platelet (mean ± SD, T/L)	232.1 ± 50.49	260.63 ± 57.04	0.000**
ANGPTL3 (ng/mL)	169.4 (130.44–246.2)	147.38 (96.98–223.31)	0.017***

Notes: Data with normal distribution were reported as mean ± SD (standard deviation) and data with non- normal distribution were reported as median and interquartile range (IQR). *Chi-Square test;**Independent – Samples T-test; ***Mann–Whitney test; p < 0.05 was considered to be statistically significant.

Abbreviations: BMI, Body mass index; HDL-C, High-Density Lipoprotein Cholesterol; LDL-C, low-density lipoprotein-cholesterol; GOT, Glutamate Oxaloacetate Transaminase; GPT, Glutamate Pyruvate Transaminase; GGT, Gamma Glutamyl Transferase; HOMA-IR, Homeostatic Model Assessment for Insulin Resistance; ANGPTL-3, Angiopoietin-Like3.

Figure 1 Plasma concentrations of ANGPTL3 in control and disease groups.

Notes: The concentration of ANGPTL3 in plasma increased from healthy control to diabetes groups. The group control was significantly higher than group disease. p-values in Mann–Whitney test were showed in figure.

Table 2 Correlation Between ANGPTL-3 Concentration and Some Clinical and Subclinical Characteristics in the Patient Group

Parameter	Control Group		Patient Group
	r	p*	r	p*
BMI (kg/m^2)	0.072	0.482	−0.076	0.447
Systolic blood pressure (mmHg)	0.097	0.344	−0.03	0.976
Diastolic blood pressure (mmHg)	0.029	0.778	0.023	0.819
Fasting Glucose Blood (mmol/L)	0.016	0.879	−0.018	0.86
HbA1C (%)	−0.116	0.256	−0.044	0.66
Insulin (mIU/mL)	−0.038	0.708	0.136	0.171
HOMA-IR	−0.04	0.699	0.125	0.208
Total Cholesterol(mmol/L)	0.074	0.47	−0.009	0.932
HDL-C (mmo/L)	0.009	0.929	−0.37	0.000
LDL-C (mmol/L)	−0.161	0.113	−0.002	0.981
Triglyceride (mmol/L)	0.059	0.063	0.275	0.005

Notes: The bold value showed the variables had correlation to markers with p <0.05. ANGPTL3 had negative correlation to HDL-C and positive correlation to Triglyceride. *Pearson’s analysis.

Abbreviations: r, Pearson correlation coefficient; p-value, correlation is significant at 0.05; BMI, Body mass index; HDL-C, High-Density Lipoprotein Cholesterol; LDL-C, low-density lipoprotein-cholesterol; HOMA-IR, Homeostatic Model Assessment for Insulin Resistance.

Figure 2 The relationship between ANGPTL3 and HDL-cholesterol in the patient group.

Notes: r, p-value with Pearson correlation between plasma ANGPTL3 and HDL-C were showed on the figure.

Figure 3 The relationship between ANGPTL3 and Triglyceride in the patient group.

Notes: r, p-value with Pearson correlation between plasma ANGPTL3 and Triglyceride were showed on the figure.