The Impact of LEP rs7799039 Polymorphism and Obesity on the Severity of Coronavirus Disease-19

Figures & data

Table 1 Comparison Between 2 Studied Groups Regarding Demographic Data

	Group I Obese Group “n=116”		Group II Non Obese Group “n=116”		P value
	No	%	No	%
Gender					0.175 N.S.
Male	72	62.0	64	55.17
Female	44	38.0	52	44.83
Age					0.127
Range	22–66		20–67
Mean ±SD	47.87±12.40		45.80±9.82
BMI					0.001*
Range	20–45		20–45
Mean ±SD	32.60±5.64		29.56±5.39

Note: *Significant difference.

Abbreviations: N.S., Not significant.

Table 2 Comparison Between 2 Studied Groups Regarding Laboratory Findings

Variables	Obese Covid 19 (116)	Non Obese Covid 19 (116)	P value
Ferritin
Range	30–880	35–201	0.001*
Mean ±SD	221.32±193.55	108.34±36.44
D Dimer
Range	0.5–3.1	0.1–1	0.001*
Mean ±SD	1.24±0.52	0.31±0.21
CRP
Range	1.02–90	0.2–18	0.001*
Mean ±SD	16.49±14.99	5.11±3.16
ESR 1 hr
Range	4–56	3–40	0.001*
Mean ±SD	16.97±12.92	12.12±6.59
2 hr
Range	9–134	7–67	0.001*
Mean ±SD	39.79±29.83	26.28±11.93
Hb A1C
Range	2.9–8.2	1.2–4.5	0.001*
Mean ±SD	5.80±1.39	3.22±0.87
FBS
Range	85–142	67–129	0.001*
Mean ±SD	101.46±12.53	94.16±11.75
PPBS
Range	100–179	86–140	0.001*
Mean ±SD	121.67±13.92	115.10±13.67
GPT
Range	20–54	10–40	0.001*
Mean ±SD	30.47±6.19	23.78±6.66
GOT
Range	18–58	17–36	0.001*
Mean ±SD	32.84±8.63	23.70±4.82
LDH
Range	120–270	100–270	0.045*
Mean ±SD	191.27±25.37	183.66±31.66
INR
Range	0.91–2.18	0.9–1.4	0.001*
Mean ±SD	1.23±0.21	1.03±0.09

Note: *Significant at level 0.05.

Table 3 Comparison Between the Studied Groups Regarding Serum Leptin ELISA Test

Variables	Group I	Group II	P value
Leptin			0.000
Range	0.50–37.00	0.50–38.00
Mean±SD	17.43±9.42	7.02±9.56

Figure 1 Comparison between the two studied groups regarding rs7799039.

Table 4 The Comparison Between Different CT Severity Score Regarding Leptin Gene rs7799039 and BMI Category

	CT Severity Score								P value
	Grade I		Grade II		Grade III		Grade IV
	No	%	No	%	No	%	No	%
rs7799039									0.001*
AA	4	8.0	0	0.0	3	17.6	8	57.1
GA	18	36.0	10	28.6	6	35.3	2	14.3
GG	28	56.0	25	71.4	8	47.1	4	28.6
BMI category									0.001*
Normal weight	9	18.0	0	0.0	0	0.0	0	0.0
Overweight	10	20.0	10	28.6	0	0.0	0	0.0
Obese	16	32.0	15	42.9	3	17.6	1	7.1
Morbid obese	15	30.0	10	28.6	14	82.4	13	92.9

Note: *Significant at level 0.05.