The Correlation Between Health Risk Factors and Diabesity and Lipid Profile Indicators: The Role Mediator of TSH

Figures & data

Table 1 The Multilevel Linear Regression Between Dependent HRFs and WC

Variables	WC
	R^2	t	F	P	β (95% CI)
Gender	0.01	−2.46	6.07	<0.05	−1.91(−3.44,-0.39)
Age	0.00	0.15	0.02	>0.05	0.004(−0.05, 0.06)
Diabetes duration	0.001	0.75	0.57	>0.05	0.05(−0.07, 0.17)
ZTSH	0.000	0.30	0.092	>0.05	0.13(−0.70, 0.96)
HOMA-IR	0.01	2.74	7.51	<0.01	0.06(0.02, 0.10)
TyG	0.04	5.16	26.66	<0.01	2.41(1.49, 3.32)
TG/HDL	0.03	4.81	23.12	<0.01	0.27(0.16, 0.38)
HDL	0.04	−5.60	31.39	<0.01	−6.70(−9.05, -4.36)
SBP	0.02	3.93	15.45	<0.01	0.08(0.04, 0.12)
DBP	0.02	3.58	12.85	<0.01	0.13(0.06, 0.20)
HbA1c	0.005	−1.82	3.30	0.07	−0.30(−0.62, 0.02)
FBG	0.001	−0.89	0.79	>0.05	−0.07(−0.23, 0.09)
P2hBG	0.007	−2.27	5.13	<0.05	−0.16(−0.31, -0.02)
UA	0.07	7.24	52.47	<0.01	0.03(0.02, 0.03)
LDL	0.001	0.75	0.56	>0.05	0.29(−0.47, 1.05)
TG	0.03	4.81	23.18	<0.01	0.94(0.56, 1.32)
TC	0.004	1.62	2.63	>0.05	0.51(−0.11, 1.13)

Table 2 The Multilevel Linear Regression Between Dependent Health Risk Factors and BMI

Variables	BMI
	R^2	t	F	P	β (95% CI)
Gender	0.00	0.40	0.16	>0.05	0.11(−0.44, 0.67)
Age	0.01	−2.88	8.28	<0.01	−0.03(−0.05, -0.01)
Diabetes duration	0.00	−0.48	0.23	>0.05	−0.01(−0.05, 0.03)
ZTSH	0.002	1.05	1.11	>0.05	0.16(−0.14, 0.46)
HOMA-IR	0.01	2.62	6.89	<0.01	0.02(0.005, 0.04)
TyG	0.04	5.57	30.98	<0.01	0.94(0.61, 1.27)
TG/HDL	0.04	5.60	31.37	<0.01	0.12(0.08, 0.16)
HDL	0.05	−6.28	39.46	<0.01	−2.72(−3.57, -1.87)
SBP	0.01	3.03	9.19	<0.01	0.022(0.01, 0.037)
DBP	0.02	4.15	17.24	<0.01	0.05(0.03, 0.08)
HbA1c	0.008	−2.31	5.35	<0.05	−0.14(−0.26, -0.02)
FBG	0.003	−1.42	2.01	>0.05	−0.04(−0.10, 0.02)
P2hBG	0.009	−2.52	6.35	<0.05	−0.07(−0.12,-0.015)
UA	0.07	7.26	52.70	<0.01	0.01(0.007, 0.012)
LDL	0.001	0.60	0.36	>0.05	0.085(−0.19, 0.36)
TG	0.04	5.40	29.15	<0.01	0.38(0.24, 0.52)
TC	0.003	1.42	2.02	>0.05	0.16(−0.06, 0.39)
HRF co-occurrence	0.05	6.26	39.20	<0.01	1.51(1.04, 1.98)

Table 3 Screening Results of Latent Categories Clustering of Health Risk Behaviors

	AIC	BIC	aBIC	LMR-LRT	BLRT	Entropy
1				<0.001	<0.001
2	6506.67	6593.36	6533.03	<0.001	<0.001	0.633
3	6425.22	6557.53	6465.45	0.4666	<0.001	0.569

Figure 1 The type of HRBs.

Table 4 The Logistic Correlation Factors and Four WC Groups

	≤P25	P25-P50	P50-P75	>P75
Gender
Female	1.0	1.0	1.0	1.0
Male	1.0	1.60(1.08, 2.38)*	1.94(0.24, 3.03)**	1.46(0.97, 2.20)
SBP
High	1.0	1.0	1.0	1.0
Low	1.0	0.98(0.64, 1.50)	1.03(0.64, 1.65)	0.55(0.36, 0.84)**
DBP
High	1.0	1.0	1.0	1.0
Low	1.0	0.86(0.52, 1.42)	0.62(0.36, 1.06)	0.53(0.32, 0.86)*
FBG
High	1.0	1.0	1.0	1.0
Low	1.0	0.79(0.48, 1.30)	0.63(0.34, 1.13)	0.78(0.64, 1.32)
P2hBG
High	1.0	1.0	1.0	1.0
Low	1.0	1.47(0.80, 2.69)	0.79(0.36, 1.70)	1.47(0.78, 2.75)
HbA1c
High	1.0	1.0	1.0	1.0
Low	1.0	0.96(0.52, 1.78)	0.67(0.32, 1.43)	1.03(0.55, 1.93)
TC
High	1.0	1.0	1.0	1.0
Low	1.0	1.31(0.80, 2.16)	1.32(0.75, 2.31)	0.72(0.45, 1.16)
TG
High	1.0	1.0	1.0	1.0
Low	1.0	0.59(0.39, 0.90)**	0.37(0.23, 0.59)**	0.25(0.16, 0.38)**
HDL
High	1.0	1.0	1.0	1.0
Low		0.54(0.36, 0.80)**	0.38(0.24, 0.60)**	0.54(0.35, 0.82)**
UA
High	1.0	1.0	1.0	1.0
Low	1.0	0.99(0.52, 1.88)	0.39(0.21, 0.73)**	0.32(0.18, 0.57)**
HRF
High		0.86(0.48, 1.54)	1.25(0.76, 2.05)	1.62(0.99, 2.63)
Low		1.0	1.0	1.0
HRF co-occurrence
≤3	1.0	1.0	1.0	1.0
4	1.0	1.29(0.78, 2.14)	1.25(0.67, 2.31)	1.25(0.68, 2.30)
5	1.0	1.48(0.87, 2.51)	1.62(0.87, 3.04)	2.46(1.37, 4.42)**
≥6	1.0	1.58(0.86, 2.91)	3.79(2.0, 7.16)**	5.50(2.98, 10.14)**

Note: *p < 0.05, **p < 0.01.

Table 5 The Correlation Between ZTSH, HRF, Age and WC

Variables	ZTSH			WC
	B	t value	P value	B	t value	P value
HRF	0.37	0.75	>0.05	7.02	1.32	>0.05
Age	0.025	1.69	>0.05	0.16	1.01	>0.05
HRF×age	−0.0075	−0.96	>0.05	−0.08	−0.97	>0.05
ZTSH				4.08	1.79	>0.05
ZTSH×age				−0.062	−1.75	>0.05
R^2	0.026			0.012
F	5.52			1.52

Notes: Mediate variables: ZTSH, moderated variables: age, independent variables: HRFs, dependent variables: WC. The model was uncontrolled covariates.

Table 6 Bootstrapped Conditional Direct and Indirect Effects (The Correlation Between ZTSH, HRF, Age and WC)

			WC
	Predictor	HRF	Effect	SE	(LL, UL)
Direct Effect	Moderator (age)	Low	3.3139	1.9333	−0.0523, 6.6801
		Medium	2.2365	2.1054	0.15044.3227
		High	1.1591	0.8653	−1.4715, 3.7897
Indirect effect			Effect	SE	(LL, UL)
	Predictor	WC
	Mediator (ZTSH)	Low	0.0345	0.2358	−0.3347, 0.6514
		Medium	−0.0308	0.0822	−0.3243, 0.0419
		High	0.0693	0.1654	−0.1519, 0.5163

Table 7 The Correlation Between ZTSH, HOMA-IR, Age and WC

Variables	ZTSH			WC
	B	t value	P value	B	t value	P value
HOMA-IR	0.027	0.24	>0.05	1.06	2.52	<0.05
Age	0.023	0.88	>0.05	0.07	0.73	>0.05
HOMA-IR×age	−0.001	−0.46	>0.05	−0.0067	−0.96	>0.05
ZTSH				1.71	2.14	<0.05
ZTSH×age				−0.023	−1.84	0.0662
R^2	0.025			0.09
F	5.21			12.12

Notes: Mediate variables: ZTSH, moderated variables: age, independent variables: HOMA-IR, dependent variables: WC. The model was uncontrolled covariates.

Table 8 Bootstrapped Conditional Direct and Indirect Effects (The Correlation Between ZTSH, HOMA-IR, Age and WC)

			WC
	Predictor	HOMA-IR	Effect	SE	(LL, UL)
Direct Effect	Moderator (age)	Low	0.7524	0.1320	0.4932, 1.0117
		Medium	0.6630	0.0972	0.4721, 0.8538
		High	0.5735	0.1369	0.3046, 0.8425
Indirect effect			Effect	SE	(LL, UL)
	Predictor	WC
	Mediator (ZTSH)	Low	−0.0082	0.0207	−0.0647, 0.0263
		Medium	−0.0087	0.0122	−0.0432, 0.0076
		High	−0.0023	0.0150	−0.0529, 0.0172

Table 9 The Correlation Between ZTSH, HRF, Age and BMI

Variables	ZTSH			BMI
	B	t value	P value	B	t value	P value
HRFs	0.37	0.75	>0.05	2.32	1.21	>0.05
Age	0.025	1.69	>0.05	0.017	0.30	>0.05
HRF×age	−0.0075	−0.96	>0.05	−0.26	−0.86	>0.05
ZTSH				1.52	1.83	>0.05
ZTSH×age				−0.02	−1.57	>0.05
R^2	0.026			0.025
F	5.52			3.18

Notes: Mediate variables: ZTSH, moderated variables: age, independent variables: HRFs, dependent variables: WC. The model was uncontrolled covariates.

Table 10 Bootstrapped Conditional Direct and Indirect Effects (The Correlation Between ZTSH, HRF, Age and BMI)

			WC
	Predictor	HRFs	Effect	SE	(LL, UL)
`	Moderator (age)	Low	1.1227	0.6226	−0.0999, 2.3453
		Medium	0.7734	0.3858	0.0158, 1.5311
		High	0.4242	0.4865	−0.5313, 1.3796
Indirect effect			Effect	SE	(LL, UL)
	Predictor	WC
	Mediator (ZTSH)	Low	0.0165	0.1008	−0.1717, 0.2460
		Medium	−0.0239	0.0412	−0.1673, 0.0232
		High	−0.0104	0.0571	−0.1779, 0.0657

Table 11 The Correlation Between ZTSH, HRF Co-occurrence, Age and WC

Variables	ZTSH			WC
	B	t value	P value	B	t value	P value
HRF co-occurrence	0.027	0.24	>0.05	3.85	3.32	<0.01
Age	0.023	0.88	>0.05	0.52	1.97	<0.01
HRF co-occurrence×age	−0.001	−0.46	>0.05	−0.036	−1.86	>0.05
ZTSH				4.81	2.17	<0.05
TSH×age				−0.072	−2.12	<0.05
R^2	0.025			0.074
F	5.21			9.84

Notes: Mediate variables: ZTSH, moderated variables: age, independent variables: HRFs, dependent variables: WC. The model was uncontrolled covariates.

Table 12 Bootstrapped Conditional Direct and Indirect Effects (The Correlation Between ZTSH, HRF Co-occurrence, Age and WC)

			WC
	Predictor	HRF co-occurrence	Effect	SE	(LL, UL)
Direct effect	Moderator (age)	Low	2.2072	0.3642	1.4920, 2.9223
		Medium	1.7298	0.2681	1.2033, 2.2563
		High	1.2521	0.3778	0.5105, 1.9943
Indirect effect			Effect	SE	(LL, UL)
	Predictor	HRF
	Mediator (ZTSH)	Low	−0.0184	0.0508	−0.1611, 0.0602
		Medium	−0.0127	0.0245	−0.0915, 0.0174
		High	0.0150	0.0404	−0.0293, 0.1605