258
Views
5
CrossRef citations to date
0
Altmetric
CLINICAL TRIAL REPORT

Teneligliptin, a DPP-4 Inhibitor, Improves Vascular Endothelial Function via Divergent Actions Including Changes in Circulating Endothelial Progenitor Cells

ORCID Icon, , , , , , , , & show all
Pages 1043-1054 | Received 09 Jan 2023, Accepted 03 Apr 2023, Published online: 13 Apr 2023

Figures & data

Table 1 Baseline Patient Characteristics

Figure 1 Study flow chart.

Figure 1 Study flow chart.

Table 2 Primary Endpoints in the Teneligliptin and Control Groups

Table 3 Secondary Endpoints in the Teneligliptin and Control Groups

Table 4 Primary Endpoint with an Analysis of Covariance Model

Table 5 Secondary Endpoint with an Analysis of Covariance Model

Figure 2 Mean endothelial progenitor cells (EPCs) between baseline and 28 weeks in the teneligliptin and control groups. Temporal changes in EPC levels from baseline to 28 weeks were not significantly different between the groups (P = 0.13). The bar graph and error bars show the mean and standard deviation, respectively.

Figure 2 Mean endothelial progenitor cells (EPCs) between baseline and 28 weeks in the teneligliptin and control groups. Temporal changes in EPC levels from baseline to 28 weeks were not significantly different between the groups (P = 0.13). The bar graph and error bars show the mean and standard deviation, respectively.

Figure 3 Mean flow-mediated dilatation (FMD) between baseline and 28 weeks in the teneligliptin and control groups. Temporal changes in FMD from baseline to 28 weeks were significantly increased in the teneligliptin group (3.8% ± 2.1%) compared with those in the control group (−0.3% ± 2.9%). The bar graph and error bars show the mean and standard deviation, respectively. *P <0.05, compared to the control group.

Figure 3 Mean flow-mediated dilatation (FMD) between baseline and 28 weeks in the teneligliptin and control groups. Temporal changes in FMD from baseline to 28 weeks were significantly increased in the teneligliptin group (3.8% ± 2.1%) compared with those in the control group (−0.3% ± 2.9%). The bar graph and error bars show the mean and standard deviation, respectively. *P <0.05, compared to the control group.