Differences and Clinical Significance of Serum 25-Hydroxyvitamin D3 and Vasohibin-1 (VASH-1) Levels in Patients with Diabetic Nephropathy and Different Renal Injuries

Figures & data

Table 1 Comparison of Baseline Data Between Two Groups of Patients

Groups	n	Age (Years Old)	BMI (kg/m^2)	Gender (%)		Smoking (%)	Drinking (%)	Hypertension (%)	Lipid Abnormality (%)
				Male	Female
DN group	143	67.5±7.3	24.16±1.70	87(60.84)	56(39.16)	50(34.97)	67(46.85)	56(39.16)	77(53.85)
T2DM group	80	65.8±7.8	24.00±1.81	43(53.75)	37(46.25)	24(30.00)	31(38.75)	38(47.50)	48(60.00)
t/χ^2		1.627	0.659	1.060		0.570	1.367	1.463	0.789
P		0.105	0.511	0.303		0.450	0.242	0.226	0.375

Table 2 Comparison of 25 (OH) D3 and VASH-1 Levels Between DN Group and T2DM Group ()

Groups	n	25 (OH) D3 (ng/mL)	VASH-1 (ng/L)
DN group	143	19.66±6.10	443.1±66.8
T2DM group	80	28.18±8.45	328.6±57.1
t		−8.679	12.914
P		0.000	0.000

Table 3 Comparison of Blood Glucose and Renal Function Indexes Between DN Group and T2 DM Group ()

Groups	n	FPG (mmol/L)	Fins (mmol/L)	HbA1c (%)	CysC (mg/L)	BUN (mmol/L)	Scr (μmol/L)	24h Urine Protein (g/24h)
DN group	143	8.65±1.30	12.49±2.81	8.51±0.89	1.10±0.34	14.59±4.40	154.2±18.7	2.89±0.85
T2DM group	80	8.38±1.14	12.01±2.55	8.34±0.80	0.85±0.20	8.30±2.21	104.3±11.8	0.16±0.05
t		1.553	1.264	1.418	6.016	11.962	21.573	28.671
P		0.122	0.208	0.158	0.000	0.000	0.000	0.000

Table 4 Comparison of Inflammatory Markers Between DN Group and T2DM Group ()

Groups	n	CRP (mg/L)	TGF-β1 (μg/L)	TNF-α (ng/L)	IL-6 (ng/L)
DN group	143	7.45±1.85	13.94±2.61	40.72±9.56	36.77±9.04
T2DM group	80	3.96±0.81	12.55±2.44	17.40±4.41	18.30±5.20
t		16.024	3.903	20.610	16.777
P		0.000	0.000	0.000	0.000

Table 5 Comparison of 25 (OH) D3 and VASH-1 Levels in DN Patients with Different Conditions ()

Groups	n	25 (OH) D3 (ng/mL)	VASH-1 (ng/L)
Microalbuminuria group	88	21.76±5.81	414.8±64.2
Massive proteinuria group	55	16.30±5.54	488.4±57.0
t		5.565	−6.958
P		0.000	0.000

Table 6 Correlation Between 25 (OH) D3, VASH-1 and Renal Function Indexes in Patients with DN

Index	25 (OH) D3		VASH-1
	r	P	r	P
CysC	−0.517	0.000	0.311	0.081
BUN	−0.486	0.005	0.274	0.136
Scr	−0.491	0.003	0.362	0.041
24hurine protein	−0.511	0.000	0.442	0.011

Table 7 Correlation Between 25 (OH) D3, VASH-1 Levels and Inflammatory Markers in Patients with DN

Index	25 (OH) D3		VASH-1
	r	P	r	P
CRP	−0.544	0.000	0.401	0.036
TGF-β1	−0.536	0.000	0.461	0.004
TNF-α	−0.628	0.000	0.552	0.000
IL-6	−0.591	0.000	0.573	0.000

Data Sharing Statement

All data included in this manuscript are available from the corresponding author upon reasonable request.