Driving Pressure-Guided Ventilation in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy: A Randomized Controlled Trial

Figures & data

Table 1 Patient Demographics and Operation Characteristics

Variables	Group L (n = 22)	Group D (n=23)	P value
Age, years	31.1 ± 7.6	32.5 ± 5.3	0.453
Height, cm	166.8 ± 9.3	163.2 ± 6.3	0.140
Weight, kg	106.8 ± 21.3	102.4 ± 18.4	0.460
BMI, kg/m^2	38.2 ± 5.5	38.3 ± 5.8	0.928
Gender, n (%)			0.284
Male	6 (27.3)	3 (13.0)
Female	16 (72.7)	20 (87.0)
ASA physical status, n (%)			0.420
II	7 (31.8)	10 (43.5)
III	15 (68.2)	13 (56.5)
Comorbidities, n (%)
Diabetes mellitus type 2	5 (22.7)	7 (30.4)	0.559
Hypertension	3 (13.6)	2 (8.7)	0.665
Dyslipidemia	13 (59.1)	17 (73.9)	0.292
Sleep apnea syndrome	10 (45.4)	8 (34.8)	0.465
Polycystic ovarian syndrome	4 (18.2)	7 (30.4)	0.339
Blood loss, mL	45 (45–50)	45 (45–50)	0.879
Infusion volume, mL	1100 (1000–1200)	1100 (1100–1200)	0.548
Duration of surgery, min	130 (124–136)	130 (125–140)	0.240
Duration of anesthesia, min	155 (145–160)	155 (154–165)	0.138

Notes: Data displayed by mean ± SD, numbers (%) or median (interquartile range).

Abbreviations: Group L, Conventional lung protective ventilation strategy group; Group D, Driving pressure-guided ventilation group; BMI, Body mass index; ASA, American Society of Anesthesiologists.

Figure 1 The CONSORT study diagram.

Notes: CONSORT figure adapted from Schulz KF, Altman DG, Moher D, CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials. PLoS Med. 2010;7(3): e1000251. Copyright: © 2010 Schulz et al. Creative Commons Attribution License.¹³

Figures 2 (A) The driving pressure of the two groups at each time point. (B) The respiratory compliance of the two groups at each time point. (C) The Pplat of the two groups at each time point. (D) The Ppeak of the two groups at each time point. Data are shown by mean ± SD. **P < 0.01, ***P < 0.001.

Abbreviations: Group L, Conventional lung protective ventilation strategy group; Group D, Driving pressure-guided ventilation group; Pplat, Plateau pressure; Ppeak, Peak airway pressure.

Figure 3 Distribution of intraoperative PEEP in the two groups. The solid line represents the median and whiskers’ interquartile range. Data is displayed by median (interquartile range). ***P < 0.001.

Abbreviations: Group L, Conventional lung protective ventilation strategy group; Group D, Driving pressure-guided ventilation group; PEEP, Positive end-expiratory pressure.

Figures 4 (A) The MAP of the two groups at each time point. (B) The HR of the two groups at each time point. (C) The ETCO₂ of the two groups at each time point. (D) The VT of the two groups at each time point. Data is shown by mean ± SD.

Abbreviations: Group L, Conventional lung protective ventilation strategy group; Group D, Driving pressure-guided ventilation group; MAP, Mean artery pressure; HR, Heart rate; ETCO₂, End-tidal carbon dioxide; VT, Tidal volume.

Schulz KF, Altman DG, Moher D. CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials. PLoS Med. 2010;7(3):e1000251.

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