Association Analysis of Triglyceride Glucose-Body Mass Index and Bone Turnover Markers in Patients with Type 2 Diabetes Mellitus

Figures & data

Table 1 Comparison of Indicators Between the Male and Postmenopausal Female Groups

	Male (N=716)	Postmenopausal Female (N=432)	P
Age (years)	56.00(46.00, 64.00)	64.00(57.00, 71.00)	<0.001
DM duration (years)	8.00(2.00, 15.00)	10.00(5.00, 18.00)	<0.001
Smoking (number)	320(44%)	8(1.9%)	<0.001
Drinking (number)	261(36%)	6(1.4%)	<0.001
BMI (kg/m^2)	26.14(23.95, 28.39)	25.78(23.42, 27.97)	0.010
Ca (mmol/L)	2.29(2.22, 2.36)	2.30(2.23, 2.37)	0.059
P (mmol/L)	1.17±0.20	1.23±0.18	<0.001
Mg (mmol/L)	0.86(0.81, 0.90)	0.85(0.81, 0.92)	0.619
UA (umol/L)	314.30(250.85, 379.30)	269.00(216.96, 329.10)	<0.001
GFR (mL/min)	97.23(72.11, 106.81)	85.68(66.21, 95.88)	<0.001
TG (mmol/L)	1.42(0.98, 2.23)	1.37(1.01, 1.97)	0.271
HDL-C (mmol/L)	1.03(0.87, 1.29)	1.22(1.04, 1.56)	<0.001
LDL-C (mmol/L)	2.70±1.06	3.03±1.90	0.001
LPA (mg/L)	138.65(79.15, 297.55)	174.80(92.20, 370.20)	0.114
HbA1c (%)	8.70(7.25, 10.20)	8.60(7.50, 10.50)	0.503
25(OH)D3 (ng/mL)	18.88(14.96, 23.39)	15.75(12.67, 20.08)	<0.001
PTH (pg/mL)	37.08(29.23, 46.77)	37.53(28.91, 49.26)	0.485
ALP (mmol/L)	75.00(60.90, 91.63)	81.00(62.60, 96.50)	0.008
OC (ng/mL)	11.94(9.71, 14.59)	13.85(11.03, 17.44)	<0.001
PINP (ng/mL)	35.79(28.29, 45.56)	41.32(31.94, 51.78)	<0.001
β-CTX (ng/mL)	0.35(0.25, 0.48)	0.40(0.28, 0.53)	<0.001
TyG-BMI	239.09(215.48, 268.29)	232.39(206.37, 258.07)	0.003

Table 2 Clinical Characteristics of Subjects by TyG-BMI Category

	Q1	Q2	Q3	Q4	P
Age (years)	62.78±11.75	60.77±12.14	59.54±11.27	54.11±13.16	<0.001
DM duration (years)	11.41±8.69	10.56±7.98	10.33±8.27	8.97±8.00	0.008
BMI (kg/m^2)	22.28(20.98, 23.53)	25.07(23.88, 26.32)	26.84(25.69, 28.12)	29.41(27.76, 31.56)	<0.001
Ca (mmol/L)	2.27(2.21, 2.34)	2.29(2.22, 2.37)	2.30(2.23, 2.36)	2.30(2.24, 2.37)	0.003
P (mmol/L)	1.21±0.21	1.18±0.19	1.19±0.19	1.19±0.19	0.346
Mg (mmol/L)	0.88(0.82, 0.91)	0.85(0.81, 0.90)	0.86(0.81, 0.90)	0.86(0.81, 0.90)	0.443
UA (umol/L)	261.91±103.82	291.05±154.65	293.22±95.28	341.23±110.64	<0.001
GFR (mL/min)	83.12(51.61, 99.78)	89.55(57.63, 102.15)	93.88(80.80, 102.49)	97.15(76.29, 107.59)	<0.001
TG (mmol/L)	0.94(0.73, 1.26)	1.24(0.96, 1.71)	1.55(1.15, 2.14)	2.25(1.62, 3.44)	<0.001
HDL-C (mmol/L)	1.26(1.03, 1.62)	1.11(0.93, 1.47)	1.11(0.94, 1.34)	0.99(0.86, 1.21)	<0.001
LDL-C (mmol/L)	2.67±2.20	2.72±1.09	2.86±1.17	3.03±1.05	<0.001
LPA(mg/L)	176.95(99.62, 401.55)	152.00(90.60, 295.60)	146.10(88.90, 342.30)	121.30(71.00, 241.20)	0.031
HbA1c (%)	8.30(6.70, 10.20)	8.50(7.30, 10.25)	8.70(7.33, 10.10)	9.00(8.00, 10.50)	0.001
25(OH)D3 (ng/mL)	17.88(13.78, 23.91)	18.52(14.23, 23.69)	16.56(12.85, 20.21)	17.06(14.26, 21.55)	0.002
PTH (pg/mL)	35.42(28.70, 46.77)	36.62(27.55, 46.04)	37.02(28.73, 49.56)	39.59(30.83, 49.83)	0.024
ALP (mmol/L)	73.20(55.80, 89.00)	74.15(60.30, 93.40)	80.45(62.45, 96.50)	80.30(65.50, 94.65)	0.002
OC (ng/mL)	14.08(11.10, 16.92)	12.36(9.83, 15.12)	12.48(10.45, 15.27)	11.66(9.30, 15.05)	<0.001
PINP (ng/mL)	39.99(30.58, 51.38)	37.82(29.47, 49.53)	38.24(30.41, 46.30)	35.36(27.84, 47.51)	0.037
β-CTX (ng/mL)	0.42(0.30, 0.55)	0.36(0.25, 0.50)	0.37(0.27, 0.50)	0.32(0.24, 0.45)	<0.001

Figure 1 Comparison of BTMs at different TyG-BMI levels.

Figure 2 Correlation between TyG-BMI and other clinical features in all T2DM patients.

Figure 3 Correlation between TyG-BMI and other clinical features in male patients with T2DM.

Figure 4 Correlation between TyG-BMI and other clinical features in postmenopausal women with T2DM.

Table 3 Multiple Linear Correlation Analysis Between TyG-BMI and OC/ PINP/ CTX

		β(95% CI)	Std.Error	Beta	t	P
All patients	OC	−0.026(−0.039, −0.013)	0.007	−0.238	−3.871	<0.001
	PINP	−0.048(−0.087, −0.009)	0.020	−0.151	−2.431	0.016
	β-CTX	−0.001(−0.002, −0.001)	0.000	−0.251	−4.113	<0.001
Male patients	OC	−0.026(−0.042, −0.010)	0.008	−0.275	−3.278	0.001
	PINP	−0.063(−0.112, −0.014)	0.025	−0.211	−2.552	0.012
	β-CTX	−0.001(−0.002, 0.000)	0.000	−0.245	−3.072	0.002
postmenopausal women	OC	−0.028(−0.053, −0.003)	0.013	−0.225	−2.233	0.028
	PINP	−0.006(−0.180, 0.035)	0.036	−0.016	−0.152	0.88
	β-CTX	−0.006(−0.078, 0.067)	0.001	−0.379	−4.233	<0.001

Table 4 Subgroup Analysis of the Association of TyG-BMI with OC/PINP/β-CTX

				Beta	P
Age	Age < 65	Male	OC	−0.271	0.004
			PINP	−0.300	0.002
			β-CTX	−0.237	0.017
		Female	OC	−0.122	0.499
			PINP	0.114	0.509
			β-CTX	−0.064	0.716
	Age ≥ 65	Male	OC	−0.260	0.299
			PINP	0.149	0.492
			β-CTX	−0.118	0.575
		Female	OC	−0.190	0.148
			PINP	−0.011	0.933
			β-CTX	−0.413	0.002
Disease duration	disease duration < 10	Male	OC	−0.413	<0.001
			PINP	−0.315	0.005
			β-CTX	−0.356	0.002
		Female	OC	−0.158	0.498
			PINP	0.182	0.459
			β-CTX	−0.371	0.143
	disease duration ≥10	Male	OC	−0.130	0.377
			PINP	−0.174	0.208
			β-CTX	−0.223	0.094
		Female	OC	−0.305	0.010
			PINP	−0.146	0.235
			β-CTX	−0.275	0.040
BMI	BMI< 24	Male	OC	0.064	0.810
			PINP	0.249	0.338
			β-CTX	0.349	0.143
		Female	OC	−0.388	0.132
			PINP	−0.383	0.199
			β-CTX	−0.047	0.840
	BMI≥24	Male	OC	−0.336	0.001
			PINP	−0.242	0.015
			β-CTX	−0.264	0.006
		Female	OC	−0.192	0.109
			PINP	−0.167	0.207
			β-CTX	−0.262	0.049
TG	TG< 1.7	Male	OC	−0.240	0.026
			PINP	−0.234	0.029
			β-CTX	−0.215	0.032
		Female	OC	−0.357	0.009
			PINP	−0.095	0.478
			β-CTX	−0.396	0.008
	TG≥1.7	Male	OC	−0.223	0.064
			PINP	−0.152	0.178
			β-CTX	−0.210	0.070
		Female	OC	−0.025	0.879
			PINP	0.015	0.936
			β-CTX	−0.189	0.237
25(OH)D3	25(OH)D3<20	Male	OC	−0.251	0.039
			PINP	−0.036	0.758
			β-CTX	−0.185	0.112
		Female	OC	−0.104	0.377
			PINP	0.085	0.485
			β-CTX	−0.234	0.045
	25(OH)D3≥20	Male	OC	−0.318	0.012
			PINP	−0.392	0.002
			β-CTX	−0.309	0.011
		Female	OC	−0.170	0.529
			PINP	−0.066	0.822
			β-CTX	0.075	0.801