Correlation Between Hemoglobin Levels and Polycystic Ovary Syndrome Metabolic Disorder

Figures & data

Table 1 Comparison of Erythrocyte Parameters Between the PCOS Group and Control Group ()

Group	PCOS Group (n=342)	Control Group (n=231)	T	P
RBC (10^^12/L)	4.75±0.37	4.69±0.34	1.915	0.056
Hb (g/L)	140.66±10.89	138.72±10.22	2.138	0.033
HCT (%)	42.06±2.90	42.35±2.77	−1.179	0.239
MCV (fL)	88.89±5.01	90.38±4.26	−3.689	< 0.001
Mean HGB content in red blood cells (pg)	29.64±2.08	29.66±1.97	−0.117	0.907
Mean HGB concentration in red blood cells (g/L)	331.39±26.08	326.73±21.43	2.246	0.025
Red blood cell distribution width (SD)(%)	41.06±3.57	40.83±3.03	0.769	0.442
Red blood cell distribution width (CV)(%)	12.88±2.21	12.40±1.02	3.054	0.002

Abbreviations: RBC, red blood cell; Hb, hemoglobin; HCT, hematocrit; MCV, Mean Corpuscular Volume.

Table 2 Comparison of General Information of Patients Between Groups [(), M (P25, P75)]

Group	Group A (n=269)	Group B (n=73)	Group C (n=199)	Group D (n=32)
Age (years)	30.32±3.81	30.21±3.65^#	33.59±4.59*	33.34±5.26
Hb (g/L)	136.85±8.85	154.70±4.05*^#	136.39±8.96^#	153.22±3.28
BMI (kg/m2)	24.28±3.81	26.66±4.57*	22.68±2.80*	22.78±2.83
FSH (IU/L)	6.09±1.91	6.35±1.73^#	8.06±3.73*	8.73±2.99
LH (IU/L)	5.55 (3.24, 8.59)	5.33 (3.48, 7.52)	2.83 (1.28, 4.33)	2.22 (1.17, 4.59)
E2 (pg/mL)	45.69 (33.11, 65.22)	45.87 (33.48, 62.71)	54.25 (37.81, 117.52)	42.85 (34.39, 56.55)
PRL (IU/L)	10.87 (8.31, 15.80)	13.41 (8.55, 16.66)	11.07 (8.07, 20.10)	8.36 (7.75, 10.39)
T (ng/dL)	33.47±17.17	35.99±17.10	24.39±10.69*^#	34.32±18.03
P (pmol/mL)	0.56 (0.42, 0.90)	0.47 (0.33, 0.77)	0.83 (0.49, 10.41)	0.47 (0.75, 4.04)
AMH (ng/mL)	7.13±4.02	6.17±3.70^#	2.62±1.07*	2.19±1.73

Notes: *Indicates P<0.05 compared with Group A, ^#Indicates P<0.05 compared with Group D.

Table 3 Comparison of Metabolic Indexes Between Groups ()

Group	Group A (n=269)	Group B (n=73)	Group C (n=199)	Group D (n=32)
FPG (mmol/L)	5.05±0.92	5.30±1.16	5.02±0.38	5.03±0.47
2-hPG (mmol/L)	6.39±1.68	7.47±3.48*	–	–
FINS (mU/L)	13.10±8.65	17.33±7.02*^#	11.51±5.89	10.75±4.64
2-hINS (mU/L)	75.19±42.21	111.17±71.76*	–	–
HOMA-IR	2.98±2.18	4.09±2.23*^#	2.55±1.34	2.52±1.29
QUICKI	0.60±0.12	0.53±0.07*^#	0.61±0.11	0.60±.0.10
TC (mmol/L)	4.49±0.91	4.77±1.03	4.58±0.77	4.67±0.99
TG (mmol/L)	1.58±1.02	1.77±0.78^#	1.19±0.67*	1.25±0.68
HDL-C (mmol/L)	1.26±0.36	1.22±0.29	1.34±0.27*	1.31±0.26
LDL-C (mmol/L)	2.33±0.76	2.87±0.90*	2.71±0.65*	2.82±0.89
apoA1 (g/L)	1.43±0.25	1.51±0.29	1.38±0.24	1.50±0.223
apoB (g/L)	0.83±0.24	0.89±0.23	0.81±0.20	0.76±0.17
Uric acid (umol/L)	313.23±89.98	346.53±74.51*^#	280.27±74.84*	284.03±92.64

Notes: *Indicates P<0.05 compared with Group A, ^#Indicates P<0.05 compared with Group D.

Table 4 Correlation Between Hemoglobin and Metabolic Indicators in Patients with PCOS

Index	r	P
BMI (kg/m^2)	0.191	< 0.001
FPG (mmol/L)	0.123	0.049
2-hPG (mmol/L)	0.152	0.049
FINS (mU/L)	0.168	0.023
2-hINS (mU/L)	0.222	0.006
HOMA-IR	0.170	0.029
QUICKI Index	−0.210	0.007
TG (mmol/L)	0.028	0.636
TC (mmol/L)	0.053	0.368
HDL-C (mmol/L)	−0.086	0.156
LDL-C (mmol/L)	0.115	0.056
apoA1 (g/L)	0.082	0.235
apoB (g/L)	0.118	0.089
Uric acid (umol/L)	0.117	0.069

Figure 1 Relationship between hemoglobin levels and related metabolic indicators ((A) BMI, (B) FPG, (C) 2-hPG, (D) FINS, (E) 2-hINS, (F) HOMA-IR, (G) QUICKI) in patients with PCOS.

Table 5 Correlation Between Metabolic Disorders and High Hemoglobin in Patients with PCOS

Components	B	SE	X^2	P	OR	95% CI
Obesity	0.488	0.613	0.635	0.425	1.629	0.490–5.412
Dyslipidemia	0.267	0.594	0.203	0.653	0.766	0.239–2.450
Hyperglycemia	0.941	1.153	0.665	0.415	2.561	0.267–24.553
Insulin resistance	3.085	0.593	27.027	< 0.001	21.872	6.835–69.988
Hyperuricemia	0.017	0.631	0.001	0.979	0.983	0.285–3.390

Figure 2 Prediction of IR in patients with PCOS based on hemoglobin levels based on the ROC curve.