The Impact of Intermittent Fasting on Non-Alcoholic Fatty Liver Disease in Older Adults: A Review of Clinicaltrials.gov Registry

Figures & data

Table 1 Characteristics of the Clinical Trials (from ClinicalTrials.gov 12.04.2023)

	Title	Status	Conditions	Intervention	n
1	Intermittent Fasting for NAFLD in Adults	Recruiting	Fatty liver IF NAFLD Liver fat	Behavioral: time-restricted, IF	25
2	Effect of Intermittent Calorie Restriction on NAFLD Patients With Disorders of Glucose Metabolism	Completed	NAFLD Disorders of glucose metabolism Type 2 diabetes Impaired glucose regulation	Behavioral: intermittent calorie restriction, 25kcal/kg/d diet	60
3	Intermittent Fasting NAFLD	Unknown status	IF NAFLD Insulin resistance Obesity Gut microbiota	Behavioral: calorie restriction	120
4	Impact of Time-restricted Feeding in NAFLD	Recruiting	Fatty liver disease Fatty liver NAFLD	Behavioral: IF, DGE diet	100
5	Short Term Intermittent Fasting and Insulin Resistance	Unknown status	Diabetes mellitus NAFLD Metabolic syndrome Obesity	Behavioral: IF. Other: time control	20

Abbreviation: n, number of participants.

Table 2 Outcome Measures with NAFLD Using if

Organ	Outcome Measures
Body	Quality of life score Dietary intake Change of weight Visceral adipose tissue content Gut microbiota Body weight Insulin resistance
Liver	Liver fat content Relative liver fat reduction proportion Change of liver enzymes: alanine aminotransferase Change of liver enzymes: aspartate aminotransferase Change of liver enzymes: glutamyl transpeptidase Evaluation of the impact of TRF on liver steatosis by CAP (dB/m) Changes in liver fibrosis by liver stiffness (kPa) under TRF Changes in FIB-4 as indirect noninvasive tools of liver fibrosis Evaluation of changes in direct noninvasive tool of liver fibrosis ELF Evaluation of changes in direct marker of liver fibrogenesis PRO-C3 (ng/mL) Evaluation of changes in liver-specific quality of life Evaluation of changes in markers of oxidative stress (AGEs) Changes in spleen volume by spleen stiffness under TRF
Blood	Change of blood glucose: fasting blood glucose Change of blood glucose: 2h post load blood glucose Change of HbA1c Change of lipid profile: total cholesterol Change of lipid profile: triglyceride