325
Views
3
CrossRef citations to date
0
Altmetric
REVIEW

Clinical Classification of Obesity and Implications for Metabolic Dysfunction-Associated Fatty Liver Disease and Treatment

ORCID Icon, , , , &
Pages 3303-3329 | Received 18 Jul 2023, Accepted 10 Oct 2023, Published online: 25 Oct 2023

Figures & data

Table 1 Definitions Used for Heterogeneity Subtypes in Obese Individuals

Table 2 The Types and Subtypes in MAFLD Individuals

Figure 1 Different forms of metabolic fatty liver disease interchanging with one another. (By Figdraw. ID:AAPSIddcb1).

Abbreviations: MHO, Metabolically healthy obesity; MUO, Metabolically Unhealthy Obese; SO, Sarcopenia-related obesity; MAFLD, Metabolic dysfunction-associated fatty liver disease.
Figure 1 Different forms of metabolic fatty liver disease interchanging with one another. (By Figdraw. ID:AAPSIddcb1).

Table 3 Treatments for Obesity and MAFLD, Considering Pathological Processes That are Targets for Therapy

Figure 2 The underlying causes of MAFLD and T2DM include visceral obesity and insulin resistance, and inflammatory factors play a significant role in the onset and progression of the illness. (By Figdraw. ID:IIAPIadaa4).

Abbreviations: T2DM, Type 2 diabetes mellitus; MAFLD,metabolic dysfunction-associated fatty liver disease; CVD, Cardiovascular disease; IL-6, Interleukin 6; IL-8, Interleukin 8; MCP-1, Monocyte chemoattractant protein-1; AHSG, Alpha-2 Heremans Schmid Glycoprotein; HRG, Heregulin; RBP4,retinol-binding protein 4; IP-10, Interferon-gamma (IFN-gamma)-induced protein 10; RANTES, Regulated upon activation normal T cell expressed and presumably secreted; MIP1, Mps1 interacting protein-1; PAI-1, plasminogen activator inhibitor-1; hsCRP, hypersensitive C reactive protein; TNF-α, Tumour Necrosis Factor alpha; NLRP3, NACHT, LRR, and PYD domains-containing protein 3; IL1b, interleukin-1beta.
Figure 2 The underlying causes of MAFLD and T2DM include visceral obesity and insulin resistance, and inflammatory factors play a significant role in the onset and progression of the illness. (By Figdraw. ID:IIAPIadaa4).