The Correlation Between Thyroid Parameters and the Ratios of Neutrophil/Lymphocyte and Platelet/Lymphocyte in Euthyroid Type 2 Diabetic Patients

Figures & data

Table 1 Clinical and Laboratory Characteristics of the Type 2 Diabetes Group and the Control Group

Variable	NGT (n=336)	T2DM (n=672)	t	P
BMI (kg/m2)	23.31±2.57	25.02±3.23	8.457	<0.001
SBP (mmHg)	130.10±15.19	131.29±16.51	1.100	0.272
DBP (mmHg)	80.88±8.47	81.43±10.18	0.855	0.393
HbA1c (%)	5.56±0.38	8.61±1.91	29.005	<0.001
FBG (mmol/L)	4.89±0.56	8.21±2.71	22.138	<0.001
TG (mmol/L)	1.28(0.92–1.81)	1.59(1.11–2.26)	6.693	<0.001
TC (mmol/L)	4.20(3.62–4.81)	4.27(3.60–4.94)	2.488	0.013
LDL (mmol/L)	2.52(2.15–3.06)	2.62(2.18–3.08)	4.486	<0.001
HDL (mmol/L)	1.21(1.04–1.43)	1.04(0.90–1.20)	10.644	<0.001
WBC (×109/L)	5.70±1.27	5.97±1.15	3.308	0.001
NEUT (×109/L)	3.39±0.94	3.61±0.90	3.664	<0.001
LY (×109/L)	1.80±0.48	1.77±0.41	−1.136	0.256
PLT (×109/L)	184.07±45.55	189.29±39.62	1.875	0.061
NLR	1.89(1.53–2.36)	2.00(1.62–2.50)	3.851	<0.001
PLR	106.47±27.98	110.84±27.59	2.359	0.019
FT3 (pmol/L)	4.98±0.50	4.90±0.57	−2.095	0.036
FT4 (pmol/L)	10.89±1.48	10.67±1.77	−2.004	0.045
TSH (μIU/mL)	2.03±0.87	2.16±1.01	1.994	0.046

Abbreviations: T2DM, type 2 diabetes mellitus; NGT, normal glucose tolerance; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; HbA1c, glycated hemoglobin A1c; FBG, fasting blood glucose; TG, triglyceride; TC, total cholesterol; LDL, low-density lipoprotein cholesterol; HDL, high-density lipoprotein; WBC, white blood cells; NEUT, neutrophils; LY, lymphocytes; PLT, platelets; NLR, neutrophil/lymphocyte ratio; PLR, platelet/lymphocyte ratio; FT3, free triiodothyronine; FT4, free thyroxine; TSH, thyroid stimulating hormone.

Table 2 Correlation Between Thyroid Parameters and Glycolipid Metabolic Parameters and Inflammatory Markers in Individuals with Type 2 Diabetes

Variable	TSH		FT3		FT4
	r	P	r	P	r	P
Age	0.005	0.892	−0.115	0.003	−0.007	0.861
Gender	0.165	<0.001	−0.204	<0.001	−0.052	0.179
BMI	0.060	0.119	0.061	0.116	−0.065	0.092
DM duration	0.027	0.481	−0.102	0.008	−0.007	0.854
SBP	0.024	0.539	−0.011	0.786	0.001	0.979
DBP	0.041	0.294	0.055	0.152	0.023	0.552
HbA1c	0.041	0.291	−0.134	0.001	−0.003	0.939
FBG	0.074	0.057	−0.062	0.110	−0.031	0.428
TG	0.137	<0.001	−0.086	0.025	−0.091	0.018
TC	0.145	<0.001	−0.137	<0.001	−0.160	<0.001
LDL	0.147	<0.001	−0.148	<0.001	−0.148	<0.001
HDL	0.049	0.201	−0.077	0.047	−0.105	0.006
WBC	0.033	0.399	−0.012	0.764	0.023	0.551
NEUT	0.172	<0.001	−0.122	0.002	−0.019	0.629
LY	−0.256	<0.001	0.183	<0.001	0.090	0.019
PLT	0.048	0.216	−0.054	0.161	−0.047	0.228
NLR	0.325	<0.001	−0.222	<0.001	−0.094	0.014
PLR	0.290	<0.001	−0.213	<0.001	−0.137	<0.001

Abbreviations: BMI, body mass index; DM duration, duration of diabetes mellitus; SBP, systolic blood pressure; DBP, diastolic blood pressure; HbA1c, glycated hemoglobin A1c; FBG, fasting blood glucose; TG, triglyceride; TC, total cholesterol; LDL, low-density lipoprotein cholesterol; HDL, high-density lipoprotein; WBC, white blood cells; NEUT, neutrophils; LY, lymphocytes; PLT, platelets; NLR, neutrophil/lymphocyte ratio; PLR, platelet/lymphocyte ratio; TSH, thyroid stimulating hormone; FT3, free triiodothyronine; FT4, free thyroxine.

Table 3 Multiple Stepwise Regression Analysis of Contributing Factors for TSH in Individuals with Type 2 Diabetes

Variable	Nonstandardized Coefficient		Standardized Coefficient	t	P	95% CI
	B	Standard Error
Gender	0.201	0.072	0.099	2.784	0.006	0.059~0.343
NLR	0.398	0.060	0.278	6.686	0.000	0.281~0.515
PLR	0.005	0.002	0.132	3.145	0.002	0.002~0.008
LDL	0.184	0.049	0.133	3.739	0.000	0.087~0.281

Abbreviations: NLR, neutrophil/lymphocyte ratio; PLR, platelet/lymphocyte ratio; LDL, low-density lipoprotein cholesterol.

Table 4 Multiple Stepwise Regression Analysis of Contributing Factors for FT3 in Individuals with Type 2 Diabetes

Variable	Nonstandardized Coefficient		Standardized Coefficient	t	P	95% CI
	B	Standard Error
Gender	−0.150	0.043	−0.130	−3.482	0.001	−0.234~-0.065
Age	−0.004	0.002	−0.075	−1.992	0.047	−0.007~0.000
NLR	−0.097	0.035	−0.120	−2.741	0.006	−0.166~-0.027
PLR	−0.003	0.001	−0.126	−2.908	0.004	−0.004~-0.001
HbA1c	−0.040	0.011	−0.133	−3.589	0.000	−0.061~-0.018
LDL	−0.091	0.029	−0.117	−3.124	0.002	−0.149~-0.034

Abbreviations: NLR, neutrophil/lymphocyte ratio; PLR, platelet/lymphocyte ratio; HbA1c, glycated hemoglobin A1c; LDL, low-density lipoprotein cholesterol.

Table 5 Multiple Stepwise Regression Analysis of Contributing Factors for FT4 in Individuals with Type 2 Diabetes

Variable	Nonstandardized Coefficient		Standardized Coefficient	t	P	95% CI
	B	Standard Error
PLR	−0.008	0.002	−0.125	−3.283	0.001	−0.013~-0.003
TC	−0.229	0.064	−0.137	−3.592	0.000	−0.354~-0.104

Abbreviations: PLR, platelet/lymphocyte ratio; TC, total cholesterol.