The Characteristics, Mechanisms and Therapeutics: Exploring the Role of Gut Microbiota in Obesity

Figures & data

Figure 1 The mechanism of gut microbiota in the pathology of obesity.

Table 1 Association Between Gut Microbiota and Obesity

Study	Study Subjects	Comparison	Change of Gut Microbiota
			Increased	Decreased
Andoh 2016.^Citation24	Japanese adult population	Obese vs Lean	Phylum: Firmicutes, Fusobacteria Genera: Alistipes, Anaerococcus, Coprococcus, Fusobacterium, Parvimonas	Genera: Bacteroides, Desulfovibrio, Lachnoanaerobaculum, Olsenella
Kolida 2017.^Citation25	Ukrainian adult cohort	Obese vs NW and UW	Phylum: Firmicutes	Phylum: Bacteroidetes
Yun 2017.^Citation28	Korean adult cohort	Obese and OW vs NW	Genera: Veillonellaceae, Paraprevotellaceae	Genera: Akkermansia, Eggerthella, Adlercreutzia
Gao 2018.^Citation26	Chinese adult population	Obese vs UW	Phylum: Bacteroidetes, Fusobacteria, Proteobacteria Genera: Fusobacterium
Peters 2018.^Citation29	American adult population	Obese and OW vs NW	Genera: Blautia Streptococcus	Genera: Dehalobacterium Oscillospira
Chavez-Carbajal 2019.^Citation30	Mexican adult population	Obese vs NW	Phylum: Firmicutes, Verrucomicrobia, Spirochaetes, Fusobacteria Genera: Faecalibacterium, Roseburia, Lachnospira, Coprococcus	Genera: Bacteroides
Oduaran 2020.^Citation31	South African adult population	Obese vs Lean	Phylum: Bacteroidetes Genera: Acetanaerobacterium ClostridiumIntestinimonas Oscillibacter Phascolarctobacterium Ruminococcus	Genera: Fusicatenibacter Parabacteroides Victivallis
Loftfield 2020.^Citation32	Northern Finland birth cohort	Obese vs NW	Phylum: Bacteroidetes Genera: Blautia Dorea Roseburia
Murga-Garrido 2022.^Citation27	Mexican children cohort	Obese vs NW	Genera: Eubacterium sp., Roseburia sp.	Genera: Bacteroides rodentium, B. intestinalis, B. eggerthii, Methanobrevibacter smithii

Notes: Comparisons of condition A vs condition B: “Increased” signifies an increase in condition A relative to condition B. “Decreased” signifies a decrease in condition A relative to condition B. There were statistically significant differences between different groups. OW, overweight; NW, normal weight; UW, underweight.

Andoh A, Nishida A, Takahashi K, et al. Comparison of the gut microbial community between obese and lean peoples using 16S gene sequencing in a Japanese population. J Clin Biochem Nutr. 2016;59(1):65–70. doi:10.3164/jcbn.15-152

 PubMed Web of Science ®Google Scholar

Koliada A, Syzenko G, Moseiko V, et al. Association between body mass index and Firmicutes/Bacteroidetes ratio in an adult Ukrainian population. BMC Microbiol. 2017;17(1):120. doi:10.1186/s12866-017-1027-1

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Yun Y, Kim HN, Kim SE, et al. Comparative analysis of gut microbiota associated with body mass index in a large Korean cohort. BMC Microbiol. 2017;17(1):151. doi:10.1186/s12866-017-1052-0

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Gao X, Zhang M, Xue J, et al. Body Mass Index Differences in the Gut Microbiota Are Gender Specific. Front Microbiol. 2018;9:1250. doi:10.3389/fmicb.2018.01250

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Peters BA, Shapiro JA, Church TR, et al. A taxonomic signature of obesity in a large study of American adults. Sci Rep. 2018;8(1):9749. doi:10.1038/s41598-018-28126-1

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Chávez-Carbajal A, Nirmalkar K, Pérez-Lizaur A, et al. Gut Microbiota and Predicted Metabolic Pathways in a Sample of Mexican Women Affected by Obesity and Obesity Plus Metabolic Syndrome. Int J Mol Sci. 2019;20(2):438. doi:10.3390/ijms20020438

 PubMed Web of Science ®Google Scholar

Oduaran OH, Tamburini FB, Sahibdeen V, et al. Gut microbiome profiling of a rural and urban South African cohort reveals biomarkers of a population in lifestyle transition. BMC Microbiol. 2020;20(1):330. doi:10.1186/s12866-020-02017-w

 PubMed Web of Science ®Google Scholar

Loftfield E, Herzig KH, Caporaso JG, et al. Association of Body Mass Index with Fecal Microbial Diversity and Metabolites in the Northern Finland Birth Cohort. Cancer Epidemiol Biomarkers Prev. 2020;29(11):2289–2299. doi:10.1158/1055-9965.EPI-20-0824

 PubMed Web of Science ®Google Scholar

Murga-Garrido SM, Orbe-Orihuela YC, Díaz-Benítez CE, et al. Alterations of the Gut Microbiome Associated to Methane Metabolism in Mexican Children with Obesity. Children. 2022;9(2). doi:10.3390/children9020148

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