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Diabetes, Metabolic Syndrome and Obesity Volume 8, 2015 - Issue
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Review

GABAergic system in the endocrine pancreas: a new target for diabetes treatment

Yun Wan1 Department of Endocrinology and Metabolism, Huashan Hospital, Medical College, Fudan University, Shanghai, People’sRepublic of China
,
Qinghua Wang1 Department of Endocrinology and Metabolism, Huashan Hospital, Medical College, Fudan University, Shanghai, People’sRepublic of China;2 Division of Endocrinology and Metabolism, Keenan Research Centre for Biomedical Science of St Michael’s Hospital, Toronto, ON, Canada;3 Departments of Physiology and Medicine, Faculty of Medicine, Toronto, ON, CanadaCorrespondence[email protected]
&
Gerald J Prud’homme4 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada;5 Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St Michael’s Hospital, Toronto, ON, Canada
Pages 79-87 | Published online: 03 Feb 2015

Figures & data

Figure 1 Hypothetical model of intraislet cell interaction.

Notes: ① Paracrine hyperpolarizing effects of GABA. ② Autocrine depolarizing effects of GABA. ③ GABA–GABAAR-Ca2+ -PI3K/Akt pathway. ④ Autocrine insulin action. ⑤ Intraislet glucagon action. There is an expanded discussion of these events in other reviews.Citation91,Citation92(\p)(p)Abbreviations: GABAAR, γ-aminobutyric acid type A receptor; IR, insulin receptor; VGCC, voltage-gated calcium channel; Gcgr, glucagon receptor; PI3K, phosphatidylinositol 3 kinase; Akt, protein kinase B.
Figure 1 Hypothetical model of intraislet cell interaction.

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