Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges

Figures & data

Figure 1 Number of islet transplant recipients from 1999–2013 in Edmonton, North America and International Islet Transplant Centers.

Notes: This data is kindly reproduced with express permission from the CITR Coordinating Center and Investigators. The Collaborative Islet Transplant Registry 2011 Seventh Annual Report. Reported data is unavailable from 2010–2013 for North America and International Islet Transplant Centers.¹⁵
Abbreviation: CITR, Collaborative Islet Transplant Registry.

Table 1 Summary of current clinical trials with refinements in islet transplantation

Category	Trial ID	Description	Institution	Estimated completion date
Islet alone	NCT00434811	Islet transplantation in type 1 diabetes – phase 3 (CIT-07)	National Institute of Allergy and Infectious Diseases	May 2014
Islet – Kidney	NCT01123187	Islet cell transplantation in patients with type 1 diabetes with previous kidney transplantation	University Hospital, Lille	March 2015
	NCT01241864	Islet transplantation in type 1 diabetic kidney allograft	University of Chicago	December 2016
	NCT01705899	Islet allotransplantation in type 1 diabetes: phase I trial comparing islet alone vs islet after kidney transplantation	Ohio State University	May 2017
	NCT00784966	Islet after kidney transplant for type 1 diabetes	Virginia Commonwealth University	September 2017
	NCT00468117	Efficacy of islet after kidney transplantation – phase 3 (CIT-06)	National Institute of Allergy and Infectious Diseases	December 2018
Alternative transplant sites	NCT00790257	Safety and efficacy study of encapsulated human islets allotransplantation to treat type 1 diabetes (subcutaneous space)	Cliniques universitaires Saint Luc Université Catholique de Louvain	December 2013
	NCT01722682	Bone marrow versus liver as site for islet transplantation	Ospedale San Raffaele	November 2014
	NCT01652911	A phase I/II study of the safety and efficacy of sernova’s Cell Pouch™ for therapeutic islet transplantation (subcutaneous space)	University of Alberta	December 2014
	NCT01379729	Functional survival of beta cell allografts after transplantation in the peritoneal cavity of non-uremic type 1 diabetic patients	Ziekenhuis Brussel/Ziekenhuizen Leuven Belgium	May 2018
Complications	NCT01148680	Trial comparing metabolic efficiency of islet graft to intensive insulin therapy for type 1 diabetes treatment	University Hospital, Grenoble	December 2014
	NCT00853424	A comparison of islet cell transplantation with medical therapy for the treatment of diabetic eye disease	University of British Columbia	June 2015
Refined portal vein protocols	NCT00679042	Islet transplantation in type 1 diabetic patients using the University of Illinois at Chicago protocol	University of Illinois	December 2013
	NCT00789308	Safety and effectiveness of low molecular weight sulfated dextran in islet transplantation	National Institute of Allergy and Infectious Diseases	August 2014
	NCT01817959	Study to assess efficacy and safety of reparixin in pancreatic islet transplantation	Multi-Centers International	November 2014
	NCT00530686	Pancreatic islet cell transplantation – a novel approach to improve islet quality and engraftment	Baylor Research Institute	December 2014
	NCT01653899	Caspase inhibition in islet transplantation	University of Alberta	June 2015
	NCT01897688	A phase 2 single center study of islet transplantation in non-uremic diabetic patients	Northwestern University	June 2015
	NCT01186562	Sitagliptin therapy to improve outcomes after islet autotransplant	University of Minnesota	September 2015
	NCT01630850	Islet transplantation in patients with (brittle) type 1 diabetes	University of Chicago	June 2019
	NCT01974674	Allogeneic islet transplantation for the treatment of type 1 diabetes (GRIIF)	Assistance Publique – Hôpitaux de Paris	January 2021
	NCT01909245	Islet cell transplant for type 1 diabetes (TCD)	City of Hope Medical Center	July 2021
Alternative cellular therapies	NCT00646724	Co-transplantation of islet and mesenchymal stem cell in type 1 diabetic patients	Fuzhou General Hospital	January 2014
	NCT01350219	Stem cell educator therapy in type 1 diabetes	Tianhe Stem Cell Biotechnologies Inc.	September 2014
	NCT01736228	Open-label investigation of the safety and efficacy of DIABECELL in patients with T1DM: xenotransplantation of encapsulated porcine islets into the peritoneal cavity	Living Cell Technologies	December 2014
	NCT01341899	Efficacy and safety study of autologous hematopoietic stem cell transplantation to treat new onset type 1 diabetes	Nanjing University Medical School	December 2015
	NCT01285934	A trial of high dose immunosuppression and autologous hematopoietic stem cell support versus intensive insulin therapy in adults with early onset T1DM	University of Sao Paulo General Hospital	December 2016

Abbreviations: CIT, Clinical Islet Transplant; GRIIF, allogeneic islet transplantation for the treatment of type 1 diabetes; T1DM, type I diabetes mellitus; TCD, T-cell depletion.

The CITR Coordinating Center and Investigators The Collaborative Islet Transplant Registry (CITR) 2011 Seventh Annual Report US Department of Health and Human Services Bethesda, MA, USA 2011 Available from https://web.emmes.com/study/isl/reports/01062012_7thAnnualReport.pdf Accessed April 9, 2014

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