Fixed-dose combinations in type 2 diabetes – role of the canagliflozin metformin combination

Figures & data

Table 1 Comparison of efficacy endpoints

Study	Design	Subjects (n)	Duration (weeks)	Outcomes	Results
					Cana 100 mg	Cana 300 mg	Placebo
Cana Mono^Citation17	RC, DB, PC	584	26	HbA1c (%)	−0.77a	−1.03a	0.14
				FPG (mmol/L)	−1.5a	−1.9a	0.5
				Weight (kg)	−2.5a	−3.4a	−0.5
				SBP (mmHg)	−3.7	−5.4	0.4
					Cana 100 mg	Cana 300 mg	Glimepiride
Cana vs SU^Citation18	RC, DB, AC, NI	1,450	52	HbA1c (%)	−0.82	−0.93b	−0.81
				FPG (mmol/L)	−1.35	−1.52	−1.02
				Weight (kg)	−3.7c	−4.0c	0.7
				SBP (mmHg)	−3.3c	−4.8c	0.2
					Cana 100 mg	Cana 300 mg	Sita 100 mg
Cana vs Sita^Citation19	RC, DB, AC, PG, NI	1,284	52	HbA1c (%)	−0.73	−0.88d	−0.73
				FPG (mmol/L)	−1.5d	−2.0d	−1.0
				Weight (kg)	−3.3d	−3.7d	−1.2
				SBP (mmHg)	−3.5d	−4.7d	−0.7

Notes:

a P<0.05 when compared to placebo;

b met pre-specified superiority margins;

c P<0.05 when compared to glimepiride;

d P<0.05 when compared to sitagliptin.

Abbreviations: Cana, canagliflozin; Mono, monotherapy; RC, randomized controlled; DB, double-blind; PC, placebo controlled; FPG, fasting plasma glucose; SBP, systolic blood pressure; SU, sulfonylurea; AC, active control; NI, non-inferiority trial; Sita, sitagliptin; PG, parallel crossover group.

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