Clinical utility of DaTscan™ (123I-Ioflupane Injection) in the diagnosis of Parkinsonian Syndromes

Figures & data

Table 1 UK Parkinson’s Disease Society Brain Bank clinical diagnostic criteria: Diagnosis of Parkinsonian syndrome

Bradykinesia (slowness of initiation or voluntary movement with progressive reduction in speed and amplitude of repetitive actions), and at least one of the following:

Muscular rigidity;

4–6 Hz rest tremor;

postural instability not caused by primary visual, vestibular, cerebellar, or proprioceptive dysfunction.

Notes: Reproduced with permission of BMJ Publishing Group Ltd. Original Source: Hughes AJ, Daniel Se, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinic-pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 1992;55(3):181–184.⁷

Figure 1 Chemical structure of 123I-Ioflupane.

Table 2 Summarized characteristics of 123I-Ioflupane³⁵

IUPAC name	N-(3-Fluoropropyl)-2β-carbomethoxy-3β-(4-[^123I]iodophenyl)nortropane
Abbreviation	[^123I]FP-CIT, [^123I]β-CIT-FP
Synonyms	123I-Ioflupane, DaTscan™
Target	DAT [IC50 = 3.5 nM] Serotonin Transporter [IC50 = 9.73 nM]

Note: Adapted with permission of Molecular Imaging and Contrast Agent Database (MICAD). Leung K. N-(3-Fluoropropyl)-2β-carbomethoxy-3β-(4-[123I]iodophenyl) nortropane. Bethesda: National Center for Biotechnology Information; 2004–2013. Available from: http://www.ncbi.nlm.nih.gov/books/NBK22986/.³⁵ DaTscan™, Ge Healthcare Ltd, Little Chalfont, UK.

Abbreviations: DAT, dopamine transporter; IC₅₀, half maximal inhibitory concentration; IUPAC, International Union of Pure and Applied Chemistry.

HughesAJDanielSEKilfordLLeesAJAccuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinic-pathological study of 100 casesJ Neurol Neurosurg Psychiatry19925531811841564476

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LeungKN-(3-Fluoropropyl)-2β-carbomethoxy-3β-(4-[123I] iodophenyl) nortropaneMolecular Imaging and Contrast Agent Database (MICAD) [Internet]BethesdaNational Center for Biotechnology Information20042013

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